Trial shows which brain cancer patients benefit from temozolomide
...e trial biopsies for molecular patterns that might indicate possible new drug targets. Temozolomide is the first chemotherapy for 30 years to have been proven effective for glioblastomas, which make up around 12 to 15% of all brain cancers with 2-3 new cases diagnosed per 100,000 population annually in Europ...New research shows plants can shuffle and paste gene pieces to generate genetic diversity
...where MULEs are known to flourish. Recent studies indicate that species evolve through the generation of new genes and/or gene variants that help a population adapt to a changing environment, for example, or to inhabit a different niche. Why are transposable elements so successful? Some think that t...Marijuana use could cause tubal pregnancies
...pian tubes, and smoking. At the same time, surveys indicate that a significant percentage of young women regularly smoke marijuana. According to the 2002 National Survey on Drug Use and Health, 13.6 percent of women aged 18 to 25 said they had used the drug within the past month. The federal survey interviews...Knock knock knocking on rhythm's neural doors
...f the rhythmic movement system." "What our results indicate is that we really deal with two very separate systems in movement," says Schaal. "There is an automatic system that, literally, functions without any thought; and a separate cognitive system that orchestrates more complex movement. And music? "Compu...Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival
...have spread do not survive. "Overall, our results indicate that telomerase gene expression is associated with an unfavorable outcome for children being treated for osteosarcoma," said Jeffrey S. Dome, M.D., associate member in Hematology-Oncology at St. Jude. Dome is senior author of the JCO report. Robert P...16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
...reatment. * Dr Ardeshir Ghavamzadeh: Trial results indicate arsenic should now be considered first-line treatment for one type of leukaemia *Dr Kim Chi: Successful results of Phase I trial of the first second generation antisense cancer drug - phase II getting under way * Dr Grant McArthur: Award winning rese...JCI table of contents September 15, 2004
...esented with fewer markers of dis-ease. These data indicate that PGI2 protects against and TXA2 promotes ather...r pancreatic progenitor cell growth, these studies indicate that it also has a vital role in regulating adult b cell pro-liferation and is a key component of th...Picking prostanoids to provide protection
...esented with fewer markers of dis-ease. These data indicate that PGI2 protects against and TXA2 promotes atherosclerosis development. The use of TP antagonists and molecules with PG-like activity may therefore aid in atherosclerosis prevention. Furthermore these data fit well with previous work that indicate...A liking for sweets, combined with novelty seeking, may predict alcoholism
... of Alcoholism: Clinical & Experimental Research indicate that alcoholic status can be predicted by a combi...inking this personality trait with sweet liking to indicate a higher risk for alcoholism. Researchers examined 165 middle-aged patients admitted to a residentia...TANGO: towards faster prognosis of Alzheimer's and Parkinson's diseases?
...ions of the protein and environmental factors - to indicate the degree of probability that particular proteins will stick together. TANGO thus opens possibilities for new diagnostic techniques for diseases that are caused by proteins that stick together erroneously. The VIB researchers also expect that TANGO ...Gene expression in liver tumors and patient prognosis
...processes in aggressive HCC. "Our results indicate that HCC prognosis can be readily predicted from the gene expression profiles of primary tumors," the authors report. Furthermore, they suggest that the unique molecular characteristics of each subclass could be useful in developing new therapies for...Growth hormone and IBD: Reduction of intestinal inflammation, promotion of growth
... and LPMC apoptosis and proliferation. The results indicate that use of growth hormone in IBD would lead to new therapeutic approaches taking advantage of improving growth and intestinal healing....Serotonin metabolites in mollusks suggest pathways for human therapies
...ewly discovered serotonin metabolites, which could indicate that serotonin sulfate is a signal for hunger. Stuart and Jason Ebaugh, a doctoral student in the neuroscience program, measured the blood levels of serotonin sulfate as a time-of-day function. It may be important for growth, most of which occurs du...Wrapping a memory with an experience, capacity for recollection detected in non-human species
...n normal individuals as well as studies of amnesia indicate the hippocampus could be crucial to recollection, definitive methods for assessing hippocampal activity in memory have largely remained out of reach. The BU research team, led by Norbert Fortin, a research associate in the Laboratory of Cognitive N...Veterinarians discover first known case of canine distemper in a wild tiger
...population, and preliminary studies by Dr. Quigley indicate that 67 percent of dogs sampled have been exposed to the virus. In addition, during the past thirteen years of the Siberian tiger study, tigers and the endangered Amur leopard have shown an increase in exposure to canine distemper. Dr. Quigley and h...Pig-human transplantation not PERVerted
...ital/Harvard Medical School, provide new data that indicate the dangers of such viral transmission may be extremely low and that pigs may be a safer source of transplantation material than previously thought. To carry out their assessment, the researchers developed a new xenotransplantation model where human ......pansion of these initiated cells. These data also indicate that Stat3, which has recently begun to emerge as a target for cancer therapy, may also be important for developing cancer prevention strategies. ...JCI table of contents: 1 September, 2004
...pansion of these initiated cells. These data also indicate that Stat3, which has recently begun to emerge as ...ital/Harvard Medical School, provide new data that indicate the dangers of such viral transmission may be extremely low and that pigs may be a safer source of t...Green tea research leads to gum and other products
...hy salivary gland and skin cells. "All of our data indicate that EGCG can lower the ROS level [of healthy cells] and keep it low," Dr. Hsu said. "This is very exciting because perhaps we can use EGCG to protect healthy cells and prevent side effects from medications that impair salivary function and cause dry...New genetic research demonstrates possible cause of inherited form of Parkinson's disease
... mobility and speech. Results of the new research indicate that in patients with a mutant alpha-synuclein gene, Parkinson's disease may be caused by a blockage within dopamine neurons. In the study, the mutant forms of alpha-synuclein protein was shown to bind to protein disposal sites within dopamine neuro...