Tag: "indirect" at biology news

How DNA copying enzyme 'stops the presses' for repair synthesizing enzyme

...ered dramatically from those deduced from previous indirect biochemical studies. In an article in the March 19, 2004, issue of the journal Cell, Duke University Medical Center biochemists Sean Johnson and Lorena Beese, Ph.D., described how they had conducted detailed structural analyses of DNA polymerase as i...

Scripps scientists describe dangerous cocktail of alcohol, brain peptides, and neurotransmitters

...oss of control over alcohol intake. The direct and indirect public health costs of alcoholism are estimated to be in the hundreds of billions of dollars yearly. Currently, there is no cure, and the neurobiology of the disease is not completely understood. A number of scientists at Scripps Research ...

Symposium examines the growing influence of aerosols on climate

...es and leading to a cascade of complex effects and indirect consequences, all of which scientists are now studying. Somerville says the lifespan of aerosols is typically weeks rather than decades. That characteristic leads to significant impacts in specific regions, in contrast to the long life of some green...

Lake restrictions make lakeshore property more valuable

...her focused on property value, which he says is an indirect marker of the economic value of the ordinance. Property value, he explains, can capture competing positive and negative effects of the ordinance on lakeshore residents, such as the assurance that the lake will be protected from future overdevelopment...

Story tips from the Department of Energys Oak Ridge National Laboratory, February 2004

...lved in such an endeavor, researchers must develop indirect ways such as methods to identify specific genes critical to survival of microbes in their quest to determine the presence of life on Earth and beyond. [Contact: Ron Walli, 865-576-0226; wallira@ornl.gov ] COMPUTING -- 10 trillion and counting . . ...

Researchers find an association between alcohol dependence and the GABAA receptor gene GABRG3

...t many genes that influence alcoholism act through indirect pathways," said Dick, "in other words, there is no gene that directly causes you to become alcoholic, but rather there are genes that alter your risk of becoming alcoholic. Accordingly, people don't inherit 'alcoholism,' per se , but rather, some p...

New insight into control of parental gene expression in eggs

...dly reduced fertility. "While this is certainly an indirect experiment -- in that we depleted the CTCF protein and saw that DNA methylation was acquired -- it is nevertheless persuasive evidence of the interaction of CTCF with the differentially methylated domain of H19," said Bartolomei. "It's a finding that...

Exxon Valdez oil spill impacts lasting far longer than expected, scientists say

...ly in their life history led to stunted growth and indirect increases in mortality while they were in the ocean phase of their lives," he said. Peterson said studies of the Exxon Valdez oil spill should lead to a new understanding of how lingering oil deposits affect species over many years, how sublethal, c...

Scientists develop a novel strategy to help prevent transplant rejection

...our approach will be equally effective against the indirect route when appropriately applied." Professor Dallman added: "While the crucial role that Notch signalling plays in development has been well documented, scientists are only just beginning to examine its role in regulating the immune system. "Now, we...

U. of Colorado team developing 'Flu Chip' for fast, accurate diagnosis

...nificant economic impact resulting from direct and indirect loss of productivity during infection. "For comparison, the corona virus that caused the recent outbreak of SARS has claimed less than 1,000 lives to date," said Rowlen. "However, as demonstrated by the public response to SARS, of great concern is t...

E-Commerce and the environment: Good news or bad?

...ion technologies makes unintended consequences and indirect impacts hard to predict, let alone analyze in any scientific sense. This is especially true when trying to predict how businesses and consumers might use increased time and productivity gains from the use of e-commerce and other information technolo...

Attack of the crazy ants - invasional 'meltdown' on an oceanic island

...ading to canopy dieback and even tree deaths. The indirect fallout from the displacement of a native keystone species by an ant invader, itself abetted by introduced mutualists, precipitates invasional 'meltdown' in this island ecosystem. Even in simple systems, unforeseen effects and novel associations foll...

Host response to anthrax lethal toxin suggests some current treatment strategies are inappropriate

...thrax infection is primarily a result of direct or indirect contact with infected animals or exposure to contaminated animal products. Bacillus anthracis, the causative agent of anthrax, is believed to induce disease and death in humans in an endotoxic shocklike manner. A comprehensive study of the effects o...

JCI Table of Contents

...thrax infection is primarily a result of direct or indirect contact with infected animals or exposure to contaminated animal products. Bacillus anthracis, the causative agent of anthrax, is believed to induce disease and death in humans in an endotoxic shocklike manner. A comprehensive study of the effects ...

SUCCESS 2002 Student Contest award ceremony

... of total energy expenditure will be determined by indirect calometry before and after spaceflight. The energy cost of physical activity will then be calculated by difference, and the body composition will be assessed by bio-impedance spectroscopy before and after the spaceflight. The next SUCCESS Student Con...

New funding mechanism for melanoma research announced

...t $30,000 to be used for direct research expenses; indirect costs are not provided. Research proposals are restricted to those basic, translational, clinical, or prevention research proposals with 100 percent applicability to melanoma. Candidates must hold the current status of clinical or postdoctoral fellow...

Researchers solve structure of key drug target

...btle mutations in the protein yielded considerable indirect evidence of how the transport protein might work. ...rising amount of information gleaned from previous indirect studies of the protein's structure and function. "It's amazing how much of it turned out to be right...

Can female adult obesity be stopped at birth?

...endogenous hypothalamic NPY concentrations and the indirect effect consists of neonatal hyperinsulinemia and/or hyperleptinemia that in turn chronically suppress hypothalamic NPY concentrations. This effect is permanent, causing a decline in food intake and body weight gain only in female adults. The cause fo...

Protein holds promise as new diabetes drug target

...ally screening for compounds that would work in an indirect way to alter glucokinase activity when they found the chemical described in the Science report. "It was a serendipitous discovery," Magnuson said. "One compound in one of their chemical libraries (of over 120,000 compounds) happened to bind to and...

Mouse study identifies protective mechanism against alcohol-induced embryo toxicity

...mated at $1.8 million per child in health care and indirect costs such as lost productivity....

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