Structural studies reveal how potassium channels are inactivated
...n two important ways, said Aldrich. They unify the indirect functional work on inactivation over the last fifty years, finally settling the mechanism of this important process. And, they settle a controversy that had arisen over the last couple of years about how an N-terminal peptide could possibly come thro......vely studied. These ion channels are the direct or indirect target of about one-third of all current medications. Malfunctions of these ion channels are at the root of epilepsy as well as heart arrhythmia and some other cardiovascular disorders. In contrast, much less is known about the ion channels in non-ex...Novel, even unlikely drugs may curb childhood leukemia
.... Lange explained. But cells may also die through indirect methods that target cancer cells while sparing normal cells. One such method is terminal differentiation, in which a cell enters a mature stage, with a limited lifespan. For example, all-trans-retinoic acid, a form of vitamin A, is used in this w...Researchers link failed cell division, Alzheimer's disease
...us studies from this team and others have provided indirect evidence of cell division in Alzheimer's disease through the detection of proteins usually involved in cell division, this paper supplies direct evidence of cell division. The scientists found a significant number of cells in brain tissue from Alzhei...Panda habitat not protected by nature reserve, say Science researchers
...ction for fuelwood," says Liu. Tourism also has an indirect effect on the degradation of the Wolong panda habitat, stimulating the local economy in a way that increases the extraction of local resources. "One of the local products purchased by some tourists is smoked pork. Because food for pigs needs to be co...Researchers pioneer techniques to lubricate microdevices
... as accurate as any previous indirect method could provide. They ... tried calculating friction from indirect measurements, such as the loss of electric current flowing over a MEMS structu...The enemy of my enemy is my friend
... defenses by themselves). One of these indirect defense responses involves the release of specific...ntil recently, these herbivore-induced indirect defenses have largely been a laboratory phenomenon, and two recent reviews have been ver...Elephants pick up good vibrations - through their feet
...quency vocalizations and mock charges may have the indirect effect of alerting other elephants of potential predators and other threats. "Seismic signals may also play a role in elephant reproduction," O`Connell-Rodwell observes. "We know that airborne vocal communication is an important component of mate fi...Humans at work and play in high altitude environments
...formance problems of visitors and has been used as indirect evidence that the natives have adapted to the high-altitude hypoxia and therefore maintain normal function. However, Bealls research findings revealed considerable quantitative differences in traits thought to offset hypoxia such as ventilation and ...Coping with natural disasters along the Pacific Rim
...k`s Disaster Management Facility will focus on the indirect socioeconomic impact of disasters, particularly in developing nations. ``Between 1990 and 1998, more than 97 percent of all natural disaster-related deaths were in developing countries,`` she says, adding that the average economic loss during a disas...Veterinary researchers seek secret to reversing birth defects
...ect from maternal immune cells, they looked for an indirect effect. Once set into action, immune cells secrete a vast array of proteins called cytokines or growth factors that regulate immune responses through cell-to-cell communication. Similar or sometimes identical growth factors are also required for the......ies appears to involve both direct (apoptosis) and indirect inhibition of growth factors that promote tumor growth. In addition, in animals LDP-341 appears to increase the effectiveness of other anti-cancer drugs by overcoming cellular resistance, which in humans is a major cause of chemotherapy failure. C......ing the p53 tumor-suppressor gene, Ras may play an indirect role in many more, says the co-lead author of the study, Stefan Ries, PhD, a postdoctoral fellow in the laboratory of senior author Frank McCormick, PhD, director of the UCSF Comprehensive Cancer Center. "Ras's suppression of p53 could play an import...Aging alters sleep and hormone levels sooner than expected
...ears to initiate treatment? Another option is an indirect form of hormonal therapy, supported by recent studies in the Van Cauter lab and elsewhere, that involves using investigational drugs to stimulate increases in deep sleep. Increasing deep sleep triggers a proportional increase in growth hormone secre...Wisconsin lake study shows persistence of acid rain effects
..."We found that the pH levels had a controlling but indirect influence for nearly every biological factor in the lake," says Frost. "The nature of the food web changed completely." Sport fish in the lake, such as bass and perch, survived the change but the offspring of fish were unable to survive. The zoopl...Study on chromosome ends may aid cancer research
...stances that could inhibit telomere lengthening in indirect ways, Zakian said. The new paper shows that Pif1p acts on the telomerase pathway itself and interacts directly with telomeric DNA, a potentially attractive feature for drug developers. One interesting aspect of Pif1p is that it is special type of enz...Do fish farms really add to the world's supply of fish?
...ing wild fish populations, aquaculture also causes indirect harm to the environment, according to the Nature study. "Many fish farms damage coastal ecosystems through habitat destruction," says Naylor. She notes that hundreds of thousands of acres of mangrove forests and coastal wetlands throughout Asia hav...Targeted Genetics presents data on arthritis gene therapy
...hotrexate, cyclosporine and etanercept. Direct and indirect costs associated with RA reached $65 billion in 1992. Sales of ENBREL for the treatment of moderate to severe RA were $366.9 million in 1999. There is no cure for RA....Asprin-like drugs may be useful for cancer treatment, study suggests
...enesis as a hopeful avenue to fight cancer by more indirect means than traditional chemo- or radiation therapy. Tumors produce growth factors, such as VEGF, to recruit new blood vessels to bring the oxygen and nutrients the tumors need to grow. These vessels also provide a route for metastasis (spread of canc......tension, guilt, somatic anxiety, psychasthenia and indirect aggression, as estimated by the Karolinska Scales of Personality (KSP) are significantly related to transcription factor AP-2beta genotype. Since important genes encoding proteins in the dopaminergic and serotonergic system have binding sites for AP-...