Scientists work to break cellular code
... pheromone from a potential mating partner, and it induces a mating response. But starve the yeast for nutrie...st while exposing the genome to the pheromone that induces mating and to butanol, an alcohol that mimics the conditions that promote filamentation. They used a...Cell death promotes learning growth
... modulation of learning on brain plasticity, which induces death and proliferation of different populations of cells. Most importantly, they introduce the notion that removing neurons from the adult brain can be an important process in learning and memory and a novel mechanism through which neurogenesis may ...Scientists uncover novel role for estrogen in bone marrow
.... Dr. Nagata and colleagues determined that 3b-HSD induces the production of estrogen, in the form of estradiol, in both male and female megakaryocyte cells. Further work demonstrated a crucial role for estradiol in proplatelet formation, as evidenced by their finding that the addition of exogenous estradiol...Hebrew University, German and British researchers develop means to help stress sufferers
... conditions. The team discovered that this stress induces a change in the expression of the acetylcholinesterase gene. Under normal circumstances, this gene produces a vital protein that adheres to neuronal synapses (the interaction sites through which nerve cells communicate with each other). Following str...Dec. 17 JAMA study shows new 'biologic' drug reduces psoriasis symptoms, improves quality of life
...sis is triggered by an immune system response that induces skin cells to grow too quickly," said Gordon, associate professor of medicine, division of dermatology, Loyola University Chicago Stritch School of Medicine, Maywood, Ill. "The skin cells also do not mature normally. As a result, the skin piles up ...Separation day arrives for Mars Express and Beagle 2
...he probe from Mars Express. A helical guide groove induces a linear velocity of 0.3 m/s (1 ft/s) and an angular velocity of 14 rpm into the probe....Parasite's enzyme structure helps address a public health issue
...odium, which causes malaria, and Toxoplasma, which induces toxoplasmosis, a disease that can lead to central nervous system disorders. Knowing how this one enzyme is assembled will help researchers better understand related parasites, Anderson says. "By using the structure of many protozoan DHFR-TS enzymes,...Researchers discover that a virus can naturally target and kill tumors
...fect tumor cells almost exclusively, and naturally induces cell death in these tumor cells." This relatively mild-mannered virus first came under scientific scrutiny as a potential vehicle for gene therapy, where modified viruses are used to ferry genetic treatments into cells. But the unmodified virus, wit...JCI table of contents, February 2, 2004
...stic fibrosis airway infections. TITLE: Salicylate induces an antibiotic efflux pump in Burkholderia cepacia complex genomovar III (B. cenocepacia) AUTHOR CONTACT: Jane L. Burns University of Washington, Seattle, Washington, USA. Phone: (206) 987-2073 Fax: (206) 987-3890 E-mail: jane.burns@seattlechildrens....Making new muscle: Researchers in Rome produce a mouse that can regenerate its tissues
...so found a special form of a protein called mIGF-1 induces the muscle to send the distress signal that summons them. "This form of IGF-1 is produced in the cells of embryos, but that production shuts down quickly after birth," says Rosenthal. "It is also produced in quick bursts when muscles are injured. Thi...Molecular mechanisms that trigger flowering in spring
...ow a molecular circuit around the protein CONSTANS induces flowering. This protein accumulates in the nuclei of plants exposed to long days of spring, but is rapidly degraded if the plant is exposed to short winter days. This molecular circuit is widely conserved in the plant Kingdom and knowledge of how it ...JCI table of contents, 16 February 2004
...l excitability in the absence of neurodegeneration induces cerebellar ataxia AUTHOR CONTACT: K. George Chand...ium to optimize cardiovascular health." TITLE: HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3 AUTHOR CONTACT: Bodo Levkau Unive...Despite confinement, crop genes can spread fast to wild
.... For example, the technique called the "exorcist" induces certain chemical reactions inside the plant cell that pulls out and eliminates the transgene once the plant no longer needs it. Another technique involves inserting the artificial gene near a gene that's bad for the plant under wild conditions, makin...JCI table of contents, March 1 2004
...infiltration with leukemic cells. TITLE: TGF-beta1 induces bone marrow reticulin fibrosis in hairy cell leukemia AUTHOR CONTACT: Josef Schwarzmeier Vienna University, Vienna, Austria. Phone: 43-40400-5459 Fax: 43-40400-4461 E-mail: Josef.schwarzmeier@akh-wien.ac.at View the PDF of this article at: https:/...DNA vaccine protects against anthrax
...gher antibody titers than PA, immunization with PA induces antibodies that are more capable of neutralizing toxin and conferring protection," says Bell. ...Researchers find a protein that controls cell growth
...levels of Skp2 are controlled by APC; APC actually induces the degradation of Skp2. Although this seeming alphabet soup of protein acronyms can be confusing to lay people, these proteins are of utmost interest to cancer researchers because they play an essential role in the cell cycle. Disruption...New approach limits damage after heart attack and improves survival, say Scripps Research scientists
...This leads to oxygen deprivation, and that rapidly induces the production of vascular endothelial cell growth factor (VEGF), which is known to promote new blood vessel growth. However, VEGF also produces the unwanted side effect of causing vascular permeability, and Cheresh and his colleagues wanted to devel...JCI table of contents, 15 March 2004
...the autoreactive T cell acting as an ergotope that induces anti-ergotypic T cells that in turn affect the aut...ith CD25 protects rats from adjuvant arthritis and induces an antiergotypic response AUTHOR CONTACT: Irum R. Cohen The Weizmann Institute of Science, Rehovot,...Fat hormone leptin alters brain architecture and activity, which in turn drives feeding behavior
...lleagues have shown for the first time that leptin induces visible changes in the synaptic connections, and recordable changes in the electrical activity of specific brain cells. Other researchers have shown that brain maps of cells can be quite plastic or changeable. Pinto, whose scientific training is in ......ls by microbial products breaks self tolerance and induces autoimmune disease AUTHOR CONTACT: Vijay K. Kuchr...gen protection. TITLE: Transcutaneous immunization induces mucosal CTLs and protective immunity by migration of primed skin dendritic cells AUTHOR CONTACT: Ig...