New approach offers potential drug-discovery shortcut
... activity of the angiogenesis factor VEGF and also induces the development of vascular networks in cultured human vascular cells. "We had a strain of fish with a very specific arterial defect, and although we knew which gene was responsible, there was a lot we didn't know about the molecular processes disr...A multi-institutional study may offer clues for the treatment of some autoimmune diseases
... in malignant T-cells and activated T-cells. dGTP induces cell death in these cell types. BCX-1777 is being tested in several Phase I and Phase I/II studies. These include a Phase I/II study of intravenous BCX-1777 in refractory T-cell malignancies, a Phase I pharmacology study of BCX-1777 in refractory ...Cannabinoids spell relief in colon inflammation
...c colon diseases. Unfortunately, THC and marijuana induces many undesirable side effects on numerous physiological functions. "One solution of this problem may be to develop substances that are able to activate CB1 receptors but do not cross the blood-brain-barrier", proposes Martin Storr, "this would constr...Nanoparticles illuminate brain tumors for days under MRI
...therapeutic agents. "Anytime there's an injury, it induces inflammation," Neuwelt said. Ferumoxtran-10 is "taken up by inflammatory cells in the brain. You can see them in stroke and MS, you can see them in tumors. Gadolinium is basically the size of a large atom and does not enter cells, while this contrast...JCI table of contents, 1 June 2004
...a Blockade Ischemia/reperfusion (I/R) lung injury induces a slew of cellular pathways that lead to organ dys... Transplantation Tolerance TITLE: CD28 ligation induces transplantation tolerance by IFN-_____dependent depletion of T cells that recognize alloantigens AU...RNAi delivery system crosses blood-brain barrier to target brain cancer
...ide of cells in the blood. Activated EGFR normally induces a flow of calcium across tumor cell membranes. Tha...eted liposome packet. Furthermore, activated EGFR induces DNA replication and cell proliferation. A radiolabeled DNA component, tritiated thymidine, is incorp......y used to sweeten soft drinks and other beverages, induces a pattern of hormonal responses that may favor the development of obesity. It is estimated that consumption of fructose has increased by 20-30% over the past three decades, a rate of increase similar to that of obesity, which has risen dramaticall...Scientists discover molecular target for treatment of T cell acute lymphoblastic leukemia
...ukemia. The researchers demonstrate that TAL1/SCL induces leukemia by interfering with a protein called E47/... tumor cells. "Our work demonstrates that TAL1/SCL induces leukemia by repressing E47/HEB activity, and suggests that HDAC inhibitors may prove efficacious in ...Altered protein involved in a novel link to Alzheimer's disease
...evident that the overexpression of the p25 protein induces all three pathological features of Alzheimer's disease: beta amyloid plaques (caused by increased Abeta peptides), neurofibrillary tangles caused by hyperphosphorylation of tau, and brain atrophy/loss of neurons. Only low levels of the protein P25 ar...Antioxidants during pregnancy may help prevent birth defects tied to alcohol
...rt. "In a cell culture system, ethanol induces the death of these cells. But when we place antioxidants into the culture together with ethanol, the cells are protected from cell death."Chen also has shown that ethanol-induced cell death is related to free radical generation. "We have used superox...Scientist honored for studies of genetic influence on chemotherapy, tumor development
...ically, and the factors that influence whether p53 induces a cell-cycle checkpoint, senescence or apoptosis. He has also employed mouse models for human cancer, such as the Em-myc oncogene-induced lymphoma in the mouse, to study cancer progression and the relationship between cancer mutations and the respon......active Rac stimulates Pak, and the active Pak then induces more Rac activation. Such regulation may be important for maintaining continuous cell movement....New compound 'highly efficacious' at reducing human tumour growth
...lar permeability, inhibits tumour angiogenesis and induces apoptosis in human tumour models said Dr. Gerhard Siemeister of Schering AG, Corporate Research, Berlin speaking at the 18th meeting of the European Association of Cancer Research today (Tuesday 6 July, 2004). Loss of cell cycle control (runaway grow...ORNL nanoprobe creates world of new possibilities
...ely thin coating of nanoparticles of silver, which induces the surface-enhanced Raman scattering (SERS) effect. Normally, when a sample is illuminated by a laser beam, there is a small reflection of light, known as Raman scattering. The light shows vibration energies, which are unique to each compound, and t...Tips from the Journals of the American Society for Microbiology
... to strain 16M levels when administered orally and induces cellular, humoral, and mucosal immune responses," say the researchers. "These results establish the usefulness of oral vaccination against respiratory challenge with virulent Brucella and suggest that WR201 should be further investigated as a vaccin...Long-term heart damage may result from constant confrontation and defeat
...provided evidence that chronic psychosocial stress induces permanent cardiac structural changes with the appearance of numerous scattered microscopic foci of fibrosis. This offers a hypothesize that a psychosocial challenge of longer duration might be able to produce a more severe structural damage, which in...Why some neonates need caffeine
...ed that increased oxygen in the tissues and organs induces a greater decrease in ventilation after ingestion of aminophylline (10 mg/kg). This study was performed in infants who did not suffer from ventilatory problems, and so each infant served as his or her own control, i.e., before and after administratio...Newly discovered protein may be key to muscular dystrophy
...f the journal Nature. Normally, a nerve cell induces a muscle cell to contract by releasing the neurotransmitter acetylcholine at the synapse -- the junction where the two cells meet. Researchers have identified transporters for most neurotransmitters, such as serotonin, dopamine and glutamate. The tra...Plumbing trees' plumbing reveals their engineering skill
...cavitation," in which mechanical stress or drought induces bubbles that block water flow. The researchers found that trees adjust their root anatomy very effectively to work in different environments. Shallow roots and especially stems have thicker walls and smaller interior diameters because they must suppo...New compound could give some types of cancer the one-two punch
...ped cell division in its tracks," he said. OSU 111 induces apoptosis cell suicide in cancer cells because it keeps key structures called microtubules from working during cell division. Microtubules distribute chromosomes to new cells. OSU 111 also prevents tumor cells from forming new blood vessels. Scient...