Tag: "inducing" at biology news

Enzyme's "Magic" May Hold Key to Anticancer and Antimicrobial Drugs

...topoisomerase II binds one segment of DNA, inducing a conformational change shown in (2). Upon binding ATP (represented by asterisks) and the other DNA segment (3), the enzyme undergoes a series of conformational changes: The A' parts of the enzyme separate, pulling apart ...

Scientists Use IGF-I To Grow New Membranes Around Neurons

...under study, IGF-I appears to be most effective at inducing myelination and preventing neural cell death, according to Cheng. Named for its structural similarity to insulin and its ability to simulate insulin's glucose-lowering properties, IGF-I is produced in the liver and is present in blood serum. During...

Presence Of Protein Extends Life; Potential Aging Mechanism Found

...ed fly strains to short doses of nonlethal warmth, inducing expression ofa protein dubbed hsp70. Flies bred to contain extra copies of hsp70 genesresponded to the warmth by producing a lot of hsp70, which substantiallyincreased their life span over a two-week period after heat treatment. Only a brief, low l...

Researchers Discover New Genetic Risk For Alzheimer's Disease

... in vitro studies, it would make sensethat APOE is inducing more of the normally soluble amyloid to deposit in thebrain as plaques," Goate explained. "I think this is the first result that hasreally suggested a connection between APOE expression and amyloid deposition,and it makes me more optimistic that the ...

Fauci: New Findings Help Explain "Rebound" Of HIV In Patients Who Discontinue Triple-Drug Therapy

... would still infect other cells. Thus, inducing HIV with a cytokine but without HAART would have a...by using a similar approach, i.e., by deliberately inducing virus expression in the setting of HAART," says Dr. Fauci. NIAID research...

Biotech Approach To Feral Cat Problem Devised

... Salmonella. The bacterial vaccine is capable of inducing the production of antibodies which recognize the ZP and block the ability of a sperm to fertilize the egg. While many people recognize Salmonella as a bacterium which causes disease in people and animals, Boyle says, the attenuated strain cannot cau...

Heart and Soul: The Blood Vessels And Brain Use Common Guide

...past 20 years in axonal guidance. They function by inducing thecollapse of outgrowing axon tips that venture into inappropriate brain areas,causing the affected axon to veer in another direction. This finding turns VEGF from a growth factor thought until now to actonly on endothelial cells into one th...

New Insights Into The Enigma Of Lengthening Longevity

... of diet, stress, and reproduction in inducing alternative mortality schedules has been demonstrated. The authors conclude that progress in understanding these causal relationships and in discovering genes and other survival attributes will lead to even longer lives....

University Of Pittsburgh Scientist Discovers How A Novel Vitamin K Stops Cancer Cell Growth

...es withincells. They exert anti-cancer effects by inducing the shutdown and subsequentdeath of a cell, commonly referred to as programmed cell death. Liver cancer is thought to be one of the three commonest cancersworldwide. The disease caused about 15,000 U.S. deaths in 1997 alone. Majorcauses of...

News Backgrounder: Duke Primate Center Successfully Fosters Mysterious Aye-Ayes

... May, when Williamsdecided to try an experiment in inducing the mother to resume lactating. WhileMarvin's mother, Morticia, was somewhat cooperative in accepting Marvin whenpresented with him, she was not producing milk, and despite occasional attemptsby Marvin to nurse, would not accommodate the infant. "We ...

Ecological Consequences Of Jasmonate-Induced Responses For Plants In Native Populations

...vities such as seed production, suggesting that inducing nicotine production may incur large resource-based costs. Hence, it is reasonable to suppose that the fitness consequences of producing this toxin will vary greatly depending on the plant's habitat. The discovery of the endogeno...

Reengineered Poliovirus Proves Effective As Vector For Prompting Key Immune Response In A Study With Mice

...d some day be used as a transporting mechanism for inducing immunityagainst disease pathogens in humans. The finding, reported in a recent issue of Proceedings of the National Academyof Science, could ultimately have implications for developing reengineeredpoliovirus vaccines for HIV, hepatitis B, other viral...

Diabetes Drug And Accutane Block Breast Cancer Cell Growth, Cedars-Sinai Researchers Find

...istically in permanently inhibiting cellgrowth and inducing apoptosis (programmed cell death) in breast cancer cells. "Troglitazone alone has a mild effect on breast cancer cells. Accutane alone hasa mild effect on breast cancer cells. Together, they have a dramatic effect,"said Dr. H. Phillip Koeff...

Discovery Of Possible New Weight Control Role For Leptin Announced By Yale University School Of Medicine Researchers

...echanism for the body to control its fat stores by inducing thegrowth of new blood vessels, which suggests a new avenue for weight regulation. The mechanism involves the action of leptin, a naturally occurringhormone known for its hunger-blocking effect on the hypothalamus, a region inthe brain. Acc...

Mouse Study Trumpets New Way To Preserve Species

...lephant and frozen for preservation, into a mouse, inducing the mouse to successfully produce an elephant oocyte, or egg. The results, published in the October issue of the journal Animal Reproduction Science, indicate that transplanted ovarian tissue may be used to regenerate reproductive cells for a wi...

How Nerve Cells Get In Touch - A Molecular Model Of Synapse Formation And Retrograde Signalling In The Brain

...tional networks between nerve cells in the brainby inducing synapse formation (Proc. Natl. Acad. Sci. USA 96, 1100-1105; Feb. 2,1999). Information in the brain is transmitted at synapses which are highlysophisticated contact zones between a sending and a receiving nerve cell. Theyhave a typical asymmetric str...

Life Among Dead Brain Cells: Discovery Could Help Improve Memory Capacity Of Stroke Victims

...rnfollowing stroke. The research was performed by inducing stroke in rodents. "Data show that new neurons are born in the brains of adult monkeys andin the brains of adult humans," says Frank Sharp, M.D., of the department ofneurology, University of California-San Francisco and one of the study'sinve...

A Versatile Signal In Vertebrate Embryogenesis: Wnt-4 Regulates Kidney Development, Sex Organ Differentiation, Neuronal Survival And Axonal Guidance

...t factors are the likelycandidates for this tubule inducing activity. Using cell lines expressingvarious Wnt genes he could induce tubulogenesis in isolated kidney mesenchyme.He further showed that Wnt-4 that was known to be required in kidney developmentis a mesenchymal factor sufficient for triggering nephr...

New Gene May Help Scientists Understand More About How the Body Grows

...iar gene familyperforming an unfamiliar function-- inducing normal posterior development in veryearly embryos--but they are also excited because the finding represents a newwindow into yet-unexplored aspects of development. In the study, first author Benjamin Sun and his colleagues at the Whitehead useda yeas...

UB Researchers Identify Specific Oral Bacteria Most Likely To Increase Risk Of Heart Disease

...o can narrow blood vessels and cause clots, and 3) inducing plateletsto aggregate, which increases the chances of clots forming. "We've known for some time that oral bacteria can precipitate thesekinds of reactions," Genco said. "We now know that these reactions help explainhow bacteria that cause gum disease...

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