Erodible plastic microspheres could be effective oral drug delivery system
...ncer and diabetes; and for delivering medicationto inflamed intestines. Proteins, such as insulin, growth hormone, anderythropoetin (used to treat anemia) are examples of drugs that would benefitfrom this new form of oral delivery. The delivery of corrective gene sequencesin the form of plasmid DNA could prov...New Form Of Gene Therapy Holds Promise For The Future
...ne can be delivered to a specific site, such as an inflamed joint or an organabout to be transplanted into a recipient, it may be possible to provideeffective anti-inflammatory treatment while avoiding systemic immunosuppressionwith its risk of infection." Dr. Richard Gaynor, professor of internal med...Detective Work Uncovers New Tick-Borne Disease In North Carolina And The Southeast
...d some of the biteswere followed by a circular red inflamed ring, akin to the rash seen inpeople bitten by ticks infected with the Lyme disease bacteria. Of the 12,000 cases of suspected Lyme disease recorded by the CDC in1995, the majority, by far, came from northern states where the diseaseis carried by th...Common Cold Caused By Multiple Viruses
...ed by a set of symptoms.These symptoms can include inflamed sinuses, nasal congestion and a sore throat. Studies done asearly as the 1960s have identified rhinovirus as a frequent cause of colds, but the number of cases inwhich rhinovirus was detected has been as low as 25 percent. Although diagnostic methods...Naturally Produced Enzyme May Be Useful In Inflammatory Arthritis
...ug, its high cost and thedifficulty of delivery to inflamed sites would limit its use. However,Ward said that...est the potentialof NEP as a therapeutic agent for inflamed joints.” Other researchers included Nancie Solan, Scherer Sander, Marilyn Townsand Joan B...Naked DNA Rejuvenates Rheumatoid Rodents
...on of bacterial cell walls soondevelop swollen and inflamed joints in the feet. The acute arthritic phaselasts several days and then develops into a long-term chronic condition that ismarked by the erosion of cartilage and bone within the joints.When the scientists injected TGF- plasmids into muscle tissue, ......ications, and many patients need surgery to remove inflamed or damagedportions of the intestines. Additionally, there is a greater risk of developingcolorectal cancer. Although environmental factors clearly contribute, these is strong evidence fromstudies of twins and affected families that IBD, especially Cr...System Offers Breath Of Relief To Workers
...associated with diseases such as lungcancer and an inflamed pancreas. A field test earlier this year at the Toxic Substances Control ActIncinerator in Oak Ridge, Tenn., checked workers for exposure to benzene. Finalresults will be reported later this summer, but preliminary results show workersreceiv...New Evidence For Growth Factor Role In Crohns Disease
...production of insulin-like growth factor(IGF-I) in inflamed and thickened intestinal tissue samples of CD patients butnot in otherwise healthy bowel tissue from the same individuals. The tissue camefrom patients during bowel resection surgery. "Somehow the gene for IGF-I was switched on in these cells an...UNC Researchers Reduce Arthritis Severity By Turning Off Molecular Switch
...kappa B and got a dramaticincrease in apoptosis of inflamed synovial tissue," he says. "It appears that bytargeting NF-kappa B in the joint, we benefit by blocking inflammation andaccelerating apoptosis in the synovium. That's the way to make this tissueshrink." The study also yielded an unexpected result. Re......sel where a plaque obstruction develops can become inflamed and that the inflammation can actually weaken the surface of the plaque obstruction, making it more prone to rupture which can cause a dangerous blood clot."This year, the 'news' is that the inflammatory response is not only localized in the blood ve......althy airways, but are produced when tissuesbecome inflamed by such insults as cigarette smoke or some bacteria and viruses,Nadel explained. In the UCSF experiments, once EGF-R binds to its two molecular partners, orligands, the EGF receptor complex sends a signal to the cell nucleus to turn onthe mucus gene,......algesic" response in the other paw, which has been inflamed byinjection of an irritant. This latter type of s...hin by exhibiting a delayed response in pullingthe inflamed paw away from the heat source, a sign that the hyperalgesic painsensation was reduced. An added bon...Novel route to lupus-like disease in mice
... of immune disorder as they aged, they did develop inflamed and scarred kidneys and autoreactive antibodies indicative of lupus-like abnormalities seen in the human disease. "The disease produced in these mice was chronic and long term, waxing and waning," said Marth. "And it doesnt appear to be due to defect...MGH researchers shed new light on how pain killers work
...ithin the central nervous system as well as in the inflamed region around the source of pain. Until now, it w...he widespread tenderness that surrounds damaged or inflamed tissue. "There clearly is a major central nervous system component in the way that the body resp...Treating acne with antibiotics leads to resistance
...ay an important role in the development of severe, inflamed acne. Antibiotics, most commonly tetracycline and erythromycin, have been used for over 20 years to treat moderate and severe forms of acne. The use of antibiotics has been connected to the development of antibiotic resistance in other bacteria, an......p explain the different timing of their entry into inflamed tissues. Now, Panina-Bordignon and coworkers have ...ssion of chemokines and chemokine receptors in the inflamed airways of asthmatic subjects. They find that two Th2-restricted chemokine receptors, CCR4 and CCR8,...Blood vessels found to signal chain of destruction in bone diseases
...ave for the first time shown that blood vessels at inflamed sites where bone loss is occurring create signals ...reased risk of fracture. The Osdobys believe that inflamed blood vessels beckon cells to the region, and then initiate their development into highly active bon...University of Pittsburgh researchers define precursors to cells that control the immune response
...hite cells, and interleukin-4, proteins present in inflamed skin, the precursors acquired a strong immune stimulatory function, differentiating into functionally mature DCs. By defining these precursor cells, researchers now can begin to investigate their therapeutic potential....Phase 3 psoriatic arthritis data for ENBREL (etanercept) announced at a national scientific meeting
...and swelling that can lead to crippling along with inflamed and irritated scaly red patches of skin throughout the body. It is a progressive and debilitating disease and because there are no treatments specifically approved for psoriatic arthritis, doctors often use therapies approved for RA, including nons...