Stanford, UCSF researchers home in on key gene in multiple sclerosis progression
...0-year adventure looking at gene expression in the inflamed multiple sclerosis brain to see what's going on in the course of this disease." Steinman and Oksenberg, a former postdoctoral fellow with Steinman at Stanford, shared senior authorship on the paper explaining their findings, which appeared in the No...Protein could help rejuvenate oxygen-starved cardiac tissue, heal wounds
...essels, the capillaries are leaky, the tissues are inflamed and swollen, and the blood vessels have an abnormal corkscrew-like shape. In the current study, researchers genetically engineered mice to overexpress the HIF-1α gene in skin cells. In response, the number of capillaries in the mices skin incr...UNC, Duke researchers discover cause of mysterious pancreatitis in some people
...h patients can also suffer from pancreatitis -- an inflamed pancreas causing pain, poor insulin production and frequent complications, Noone said. That fact led the researchers to suspect that some people with pancreatitis of unknown origin and without the pronounced pulmonary symptoms characteristic of CF m...MPO generates nitrotyrosine in the subendothelial space
...loperoxidase (MPO) colocalizes with fibronectin in inflamed vessels. This finding provides a ready explanation for the specific accumulation of nitrotyrosine residues in the subendothelial space, but it also raises the question of how an enzyme produced in the lumen of the vessel by activated neutrophils can ...The anti-inflammatory effect of apoptotic bodies
...optosis. Exogenous apoptotic cells introduced into inflamed lung tissue in vivo are taken up by local macrophages, which then release active TGF-b1 and suppress the effects of inflammatory cytokines. Ligation of the PSR appears to be critical for this effect, since instillation of PS vesicles alone confers a ...Pain in the gut? Don't blame stomach acid
...mes to cooling the burning pain of gastritis or an inflamed stomach lining, reducing the amount of acid in the stomach may seem like a good idea. But two new studies with laboratory mice, conducted by Howard Hughes Medical Institute scientists at the University of Michigan Medical School, indicate it could be...Adhesive interactions in contact dermatitis
...type hypersensitivity, requires migration into the inflamed region of lymphocytes and granulocytes, as well as dendritic cells (DCs) and other antigen-presenting cells (APCs). Adhesive interactions of these migratory cells with the vascular endothelium and with other cell types and extracellular macromolecule...Dietary soy reduces pain, inflammation in rats
... painful heat stimuli and had less swelling of the inflamed region when fed a diet based on soy protein. More...ate a painful heat stimulus before withdrawing the inflamed paw, and how they reacted to varying pressures applied to the paw with a series of nylon filaments. ...Abnormal chemical bonds cause bleeding disorder
...critical for recruiting circulating white blood to inflamed blood vessel walls, revealed that bond kinetics are responsible for controlling the interaction between these cells and the vessel wall. Diacovo theorized that the same was true for vWF and platelets. To test the idea, Diacovo and a team of research...Ulcer-causing bacteria use stomach inflammation to their advantage
...in engineered to lack BabA still adhered to highly inflamed stomach tissue from an H. pylori infected person, ...gen, which is rare on healthy cells but present on inflamed cells. The investigators captured a fragment of the bacterial adhesin protein using a technique cal...Carbon nanotubes found to fluoresce
...ic targets within the body, such as tumor cells or inflamed tissues. Targeting would be achieved by wrapping the tubes with a protein that would bind only to the target cells. Since nanotubes fluoresce with a single wavelength of light, and different diameter nanotubes give off different wavelengths, it may b...University of Georgia researchers link increased risk of illness to sewage sludge used as fertilizer
...lower human colon and tends to invade irritated or inflamed tissue. "The EPA did not consider S. aureus to be a significant public health risk even though it is a leading cause of hospital-acquired infections and is commonly found in sewage," said Lewis. "When approving sludge for use as a fertilizer, EPA loo...Antegren (natalizumab) clinical study results published in New England Journal of Medicine
... In Crohn's disease, immune cells migrate into the inflamed gastrointestinal tract and once there, they amplif...oodstream and prevent them from migrating into the inflamed gut tissue in Crohn's disease or the brain tissue in MS. Natalizumab, a drug in development by Elan...Clinical study results published in NEJM show promising data on Antegren (natalizumab)
... prevent them from migrating into the brain or the inflamed gut tissue and worsening the disease condition. Phase III Trials in MS Fully Enrolled Based on the promising findings in Phase II, Biogen and Elan have collaborated on two Phase III trials in MS which are both fully enrolled. The AFFIRM (natalizumab...Animal study demonstrates carbon monoxide may help heart patients
...lls lining the vessel are damaged, they may become inflamed and multiply, reblocking the artery. A similar problem can occur following heart transplantation, leading to chronic graft failure, the primary reason behind organ rejection. "These situations develop when lesions appear in between two layers of cell...Results from open-label Raptiva study suggest continued benefit with long-term treatment
...s grow abnormally, resulting in thick, red, scaly, inflamed patches. Plaque psoriasis, the most common form o...tely 2.3 million Americans and is characterized by inflamed patches of skin ("lesions") topped with silvery white scales. Psoriasis can be limited to a few spo...Phase III study results with Raptiva in the treatment of psoriasis presented at Annual AAD meeting
...s grow abnormally, resulting in thick, red, scaly, inflamed patches. Plaque psoriasis, the most common form o...ely 2.3 million Americans, and is characterized by inflamed patches of skin ("lesions") topped with silvery white scales. Psoriasis can be limited to a few spo...Schepens Eye Research Institute scientists at ARVO
...erapy. Microscopic examination of the retinas from inflamed eyes treated by gene therapy for a-MSH displayed normal, healthy structures unlike the untreated eyes where the retinal tissues displayed damage, cell loss, and disorganization. The researchers believe that treatment with a-MSH not only can decrease ...Pancreatic cancer linked to errant reactivation of embryo cell pathway
...activity was seen in cancer cells and cells in the inflamed pancreas. In addition, the investigators found that when Notch signaling was blocked in test tube studies, they were able to prevent the early cellular changes leading to pancreatic cancer. The investigators are now attempting to block Notch signali...Respiratory manifestations may be secondary to inflammation in cystic fibrosis patients
...important role in the influx of neutrophils in the inflamed airways. Locally, bacterial toxins and inflammatory mediators can directly activate the neutrophils to carry out their cytotoxic activities. Another cause may be that in CF patients, impaired neutrophil functions may contribute to an abnormal relea...