Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
...This immune therapy uses bacteria that induce both inflammation and an immune response to specific tumor antigens," which together hit the tumor with generalized antitumor chemicals, such as interferon and tumor necrosis factor, as well as activated T-cells that attack and kill the tumor, Portnoy said. "Listeria ...Gene clusters predict atherosclerosis severity, susceptibility
... the severity cluster tended to be involved in the inflammation process, while those related to susceptibility tend to mediate cellular responses that occur prior to the inflammatory process. "While the methods we used to identify these genes do not have immediate clinical applications, they do play an ...Research suggests new avenue for stopping, preventing colon cancer
...a major target for drugs that relieve the pain and inflammation of arthritis, but COX-2 gene expression is also elevated in a variety of malignancies including colorectal tumors. COX-2 generates several potent, hormone-like substances called prostaglandins that play a role in a wide variety of physiological func...New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
...s response to inflammation, the connection between inflammation and malignancy, and how the delicate balance betwe... and Signal Transduction, explained that normally, inflammation associated with malignancy activates NF-kB, TNFα and TRAIL, all at the same time. However, NF-...USC study links historical increases in life span to lower childhood exposure to infection
...nflammation. Infectious diseases cause chronic inflammation in the blood that, decades later, leads to heart a...with observations that modern-day drugs that fight inflammation also reduce the risk of cardiovascular disease and possibly Alzheimer's. Drug treatments mi...JCI table of contents September 15, 2004
...noids to Provide Protection Atherosclerosis is an inflammation in the lining of the arteries. Biological chemical...nt of atherosclerosis. The role of prostanoids in inflammation is well known, based on studies of aspirin-like non-steroidal anti-inflammatory drugs, which act to ...Picking prostanoids to provide protection
Atherosclerosis is an inflammation in the lining of the arteries. Biological chemical...nt of atherosclerosis. The role of prostanoids in inflammation is well known, based on studies of aspirin-like non-steroidal anti-inflammatory drugs, which act to ...Columbia research to examine gene influence on severity of peridontal disease, therapy response
...curs when infection of the gums goes untreated and inflammation spreads to ligaments and bone that support the teeth. The disease is the leading cause of tooth loss in adults. Currently, periodontitis is classified into two groups chronic and aggressive that are categorized based on clinical signs after consid...Growth hormone and IBD: Reduction of intestinal inflammation, promotion of growth
...l bleeding 4. Intermittent fever 5. Arthritic-like inflammation of the joints 6. Inflammation of the skin or eyes,...t growth hormone itself is able to directly reduce inflammation in the diseased intestine, as well as promoting growth. In the long run, "this may lead to new ther...The impact of genetic variations on the treatment of early rheumatoid arthritis
Characterized by inflammation in the connective tissues of the joints, rheumatoid arthritis (RA) can be a painful, crippling autoimmune disease. Traditionally, patients have been treated with disease-modifying antirheumatic drugs, or DMARDs, such as methotrexate (MTX). Several n...Novel IBD therapeutic approaches reported from Washington Univ., Barcelona, LSU at APS meeting
... therapies. Platelet recruitment in intestinal inflammation modulated by ICAM-1, P-selectin, PSGL-1 Researchers from LSU and the University of Muenster studied the mechanisms responsible for platelet-WBC and platelet-endothelial cell (EC) interactions that occur in experimental colitis. This was prompted b...New research shows air pollution can reduce children's lung function
...etard lung development. Gauderman believes chronic inflammation may play a role, with air pollutants irritating small airways on a daily basis. Scientists also suspect that air pollutants might dampen the growth of alveoli, tiny air sacs in the lungs. The research team will continue to follow the study participan...Hunting illusive signs of natural selection
...ced because they all have something to do with the inflammation immune response. Some of these genes are known to affect risk of genetic disease, but most are not associated with genetic diseases. "It is very difficult to see a compelling signature of natural selection if we look at only one gene, but if we lo...... protein called TNF alpha, which also triggers the inflammation process. The researchers found that Compound 3 als...cause joint and tissue damage. Thus, the secondary inflammation from these cells would be prevented." However, he said, further studies in his laboratory will conc...Bone marrow cells routinely help with wound healing
...one marrow cells are involved in wound healing and inflammation now we have data that shows bone marrow cells are involved in normal skin maintenance, in maintaining the matrix environment and integrity of the skin." Bone marrow has been studied for a number of purposes in recent years because it is rich in s...New imaging technology at Joslin shown to detect early signs of type 1 diabetes
...own as "insulitis"). A very early marker of this inflammation is increased permeability (leaking) of the tiny blood vessels surrounding and within the islets. Until recently, the only way to track type 1 diabetes in its earliest stages was to measure blood levels of autoantibodies (the immune system's "guided ...OHSU-VAMC study sheds light on estrogen's benefit for MS
...an lead to fetal rejection, as well as the chronic inflammation that is the root of autoimmune disease. "It's very well known that pregnant women are in remission. They do feel better," Offner said. "If you could mimic pregnancy somehow, it would be great" as a therapy. Bourdette said many of his patients have to...Regular physical activity really does boost immune system in older men
...n intradermal injection, or skin test, of KLH with inflammation measured each day for five days to assess anti-KLH delayed-type hypersensitivity response (DTH). There was significant reduction in all anti-KLH measures with aging except for anti-KLH IgG2. The physically active older group had significantly higher ...Penn scientists identify novel pathway in aneurysms
...veloping aneurysms increases significantly when an inflammation pathway important in asthma is activated. Mice without the inflammation gene were protected from aneurysms. Colin D. Funk, PhD, former Professor of Pharmacology and Medici...Sweet success in targeting sugar molecules to cells in living animals
...as in interaction with pathogens, and in mediating inflammation and disease. The research may also make it possibl...glycosylation of blood vessels at sites of chronic inflammation that are characteristic of disease. There are even some reports in changes of glycosylation in the b...