Duke Researchers Discover Candidate Susceptibility Gene For Autoimmune Disease
...ead, discovereda gene that appears to regulate the inflammatory response." Working with Duke University Arthrit...ibodies against theirown tissues that represent an inflammatory autoimmune response. By comparingtheir mice with other animals that had similar clinical signs, the ......ause hepatitis B, hepatitis C, psoriasis and other inflammatory diseases,as well as drug-resistant infections. Researchers also can use EGSs to inactivate mRNA molecules in a highlyselective way to gain a better understanding of how cellular chemistryfunctions. In this study, drug sensitivity was...Molecular Piracy Turns Protein Into Traitor
...s was hunting for a molecule that would prevent an inflammatory immune response that might clear the virus. "The ...probably using the novel chemokine to shut off the inflammatory response that would normally be associated with a tumour. This means it may also be a useful tool in...NIDR Supports Total Genome Studies Of Major Oral Pathogens
...each year in the United States. LJP is a chronic inflammatory infection of thegingiva and underlying bony tissues, and there is no effective prevention. Treatment involves surgical or mechanical removal of diseased tissues ("scalingand planing"), coupled with antibiotic therapy. Despite such extensivetreatment...New Form Of Gene Therapy Holds Promise For The Future
...vel of a geneticallyengineered protein responds to inflammatory signals produced by the micethemselves. This metho...ential for treating chronic relapsingand remitting inflammatory diseases, such as rheumatoid arthritis, and organtransplant rejection. "Our long-range goal ...Regulator Of Fat Thermostat Found
...isol, iscommonly used to treat arthritis and other inflammatory conditions. The researchers tested blood samples taken before, during and after a four-daytreatment period for concentrations of insulin and other hormones as well asleptin. By the third day of dexamethasone treatment, obese patients' leptinlevels ......ultidrug resistance in cancer,autoimmune diseases, inflammatory diseases, and neurodegenerative diseases....Women Younger Than 30 Need To Be Screened For Chlamydia
...ied early and treated before theyprogress topelvic inflammatory disease," adds Quinn. The screening was done with a new, simple urine test that is more sensitivethan previoustests for the microbe that causes the disease, Chlamydia trachomatis, saysQuinn. In their studyof 7,699 women at two family planning...Researchers Take Major Step Toward Cracking Ebola Code
...ecreted by the virus, appears to interferewith the inflammatory response that is used at a cellular level to fight...of glycoprotein (sGP) mightact as a decoy to steer inflammatory cells away from the transmembrane form ofglycoprotein (GP). However, Nabel says it now appears sGP ...Age-Based Screening Is Cost-Effective Method To Control Chlamydial Infection
...e than 4 million new cases occureach year. Pelvic inflammatory disease, a serious complication of chlamydialinfec...fined medicaloutcomes as prevented cases of pelvic inflammatory disease, chronic pelvic pain,ectopicpregnancy, infertility, male urethritis and epididymitis in adul...Study Shows: Just Say NO To Bone Loss
...ss." The discovery also may have applications for inflammatory conditions such asperiodontal disease, and the bon...ton loses too much bone,leading to osteoporosis or inflammatory bone disease. As for the naughty (and nice) nitric oxide, there are actually three differentenzymes ...Three-Dimensional Structure Of Human Lung Tryptase Determined, An Enzyme Involved In Allergic Asthma
... and is released in various allergic and certain inflammatory disorders such as asthma, psoriasis, rheumatoid arthritis, interstitial cystitis, and multiple sclerosis. Tryptase has been implicated as a causal mediator of such disorders and its involvement in the pathogenesis of asthma has recently ...... Patients with premature atherosclerosis -- an inflammatory disease of theblood vessels of the legs which usually strikes young men -- respond well to thegene therapy. Isner says this finding is intriguing since these patients havegenerally been considered to be unresponsive to any therapy. In a...... is the major cytokine that induces protective inflammatory reactions against bacteria such as Salmonella and kills tumor cells, but also causes severe tissue damage when produced in excess such as in rheumatoid arthritis, transplant rejection, multiple sclerosis, organ failure or septic shock, an...New Look At How Cells Move Could Shed Light On Tumor Growth
...mplicationsfor a wide range of diseases, including inflammatory problems such as arthritisand asthma as well as cancer invasion and metastasis, said Anna Huttenlocher,an assistant professor of pediatrics in the University of Illinois Collegeof Medicine at Urbana-Champaign and an affiliate in the department of cel...Naturally Produced Enzyme May Be Useful In Inflammatory Arthritis
...rs have discovered a potential method tohelp treat inflammatory forms of arthritis by using an enzyme naturallypro...peptidase (NEP) couldreduce some of the effects of inflammatory arthritis, according to a studyin a recent issue of the journal Inflammation . “NEP hold...Toxic Protein That Interferes With Brain Signals May Trigger Onset Of Alzheimer's Disease
...e said. ADDLs apparently form when certain inflammatory proteins are present inthe brain. One such protein, clusterin (or Apo J), is elevated in the brains ofpatients with Alzheimer's disease. Earlier research conducted by Grant A. Krafftand Caleb E. Finch, two of the investigators on this study, found th...... the major APC of the brain. Not only inflammatory lesions to the brain can initiate this state of increased "immune responsiveness" but also neurodegenerative conditions of many kinds. Using explant cultures of neuronal tissue and a confocal laser scanning microscopy based...Naked DNA Rejuvenates Rheumatoid Rodents
...produced promisingresults in animal models for the inflammatory disorders, lupus and colitis. Dr. Wahl felt that a similar approach might be an excellent way to treatarthritis in the experimental animals, and the initial success of this studylays the groundwork for further testing and clinical development.Workin......ibility todate to manage and influence the chronic inflammatory process and stop the development offibrosis resulting in severe chronic pain, pancreatic insufficiency and secondary diabetesmellitus. At the same time, chronic pancreatitis constitutes a cancer risk. This is why scientistsat the collaborative resear...