Tag: "inflammatory" at biology news

Scientists ID A Protein With Punch As Infection-Inflammation Fighter

... migrationinto tissues, which would be the typical inflammatory sequence. "This ability of PR-39 to block multiple sites in the biochemical pathway that'sinvolved in reperfusion injury is a very exciting finding," say the K-Statescientists. "It suggests that PR-39's overall effectiveness in an actual diseasesitua...

Transplanted Skeletal Muscle Mimics Heart Muscle; Helps Failing Heart Pump, Duke Researchers Say

... In the remaining five rabbits, immune system inflammatory cells appearto have destroyed the injected muscle cells. Taylor said this is a naturalresponse. The body sends immune system cells to the heart to clear out deadheart cells, and in this case they also cleared out the injected cells. She saysthat in t...

Vertex Pharmaceuticals/Yale Research Team Uses Gene Knockout Mice To Establish Role Of Caspase-9 In Neuronal Cell Death Pathway

...al trials of VX-740, an inhibitor of ICE targeting inflammatory diseases, later in 1998. Vertex has a research pro...ses, multidrug resistance in cancer,autoimmune and inflammatory diseases, and neurodegenerative diseases. There can be no assurance that compounds that are discover...

Blood Levels Of C-Reactive Protein May Predict Heart Attack And Stroke Risk In Women As Well As Men

...hey say, that theremay be interactions between the inflammatory process and menopause itself. The researchers caution that standard laboratory tests for C-reactiveprotein are not sufficient to determine cardiac risk. "Physicians and theirpatients need to understand that only 'high-sensitivity' or 'ult...

New Evidence For Growth Factor Role In Crohns Disease

...CD), a chronic,incurable, and frequently disabling inflammatory bowel disorder, new researchshows. Scientist... patientswith ulcerative colitis, the second major inflammatory bowel disorder, one thatinvolves only the colon. Lund says the bowel in some CD patients "tries to o...

Scientists Discover How Bacteria Protect Themselves Against Immune System

...a new field ofresearch." NO is a toxin produced by inflammatory cells that injures or kills bacteria. Over time, however, a mechanism has evolved that prevents NO from damagingbacteria. This detoxification of NO allows bacteria to survive. Without thisprotection, they would be unable to infect the host. Intere...

NIEHS Finds Protein That Counteracts Inflammation And Wasting That May Target Rheumatoid Arthritis And Crohn's Disease

...tein which may help in thequest for drugs to fight inflammatory diseases including rheumatoid arthritis,Crohn's di...uction stimulated by TNF itself cancause a host of inflammatory ills, such as those mentioned above, and thephysical wasting that accompanies many cancers and AIDS....

Phase III Results Suggest Potent Antiviral Activity For Vertex And Glaxo Wellcomes Second-Generation HIV Protease Inhibitor Agenerase TM

...ses, multidrug resistancein cancer, autoimmune and inflammatory diseases, and neurodegenerativediseases. There can be no assurance that clinical trials will continue, that initialresults will be predictive of any future results, that drugs under developmentby Vertex or its partners will receive marketing approval...

Scientists Sequence Chlamydia Trachomatis Genome

...tely treated chlamydialinfections result in pelvic inflammatory disease (PID), an infection of theupper reproductive tract. The resulting tubal scarring leads to infertility,tubal pregnancy and chronic pelvic pain. Chlamydial infection also increasesthe risk for HIV infection. Researchers have found the study...

UNC Researchers Reduce Arthritis Severity By Turning Off Molecular Switch

...tis because it controls the expression of numerous inflammatory genes, andwe knew that it's activated within the arthritic synovium. Around that time, ourcollaborator, Dr. Al Baldwin, published his pioneer study demonstrating thatactivated NF-kappa B is needed to protect cancer cells in vitro from apoptosis,or pr...

EMAP II: A Cytokine Regulated By Apoptosis

...of EMAP II into the mouse footpad results in an inflammatory swelling response characterised by a cellular infiltrate and edema. Cloning of the EMAP II-cDNA revealed that EMAP II is translated as a precursor protein which is processed to become the biologically active mature form that is subsequ...

New Evidence Points To Role For Free Radicals In Alzheimer's Disease

...ase, but there'sgeneral agreement that there is an inflammatory component, and inflammation isassociated with oxidant stress," says FitzGerald. "So, it becomes relevantwhether drug targets associated with inflammation will represent distinct oroverlapping targets from those involved in oxidation. In other words, ...

American Heart Association Announces Top 10 Research Advances For 1998 -- Gene Therapy Among The List

...drug, and recent research suggests that the body's inflammatory response to an unnatural condition in the body -- ...rous blood clot."This year, the 'news' is that the inflammatory response is not only localized in the blood vessel wall," Fuster says. "It also can occur not only ...

UF Researchers: Gene Therapy Replaces Critical Protein In Animal Model Of Often-Fatal Lung-Liver Disease

...iety of organs, and it inducesa very low immune or inflammatory response, so the genes inserted persistafter just one application. Current treatment for A1AD includes avoiding exposure to cigarette smokeand weekly injections of alpha-1-antitrypsin. Gene therapy could somedayreplace the need for weekly shots for ...

Growth Factor Contributes To Angiogenesis

... howangiogenesis contributes to tumors and chronic inflammatory diseases such asrheumatoid arthritis and psoriasis. It may also help researchers develop newstrategies for treating angiogenesis-dependent diseases. The results appear inthe February issue of the American Journal of Pathology. Led by Peter ...

New Biomaterial May Replace Arteries, Knee Cartilage

... than being made from silicone,which is suspect in inflammatory disorders in breast implant patients. Second,it has enough mechanical strength that it will not burst under normalphysiological conditions. And Salubria has enough elasticity and compliance thatit will pulsate in rhythm with the heart under normal ph...

Immunex And Wyeth-Ayerst Laboratories Advance Enbrel Into Phase II/III Clinical Trial For Chronic Heart Failure

...pany's products offer hope to patientswith cancer, inflammatory and infectious diseases. Wyeth-Ayerst Laboratories, a division of American Home Products Corporation, isa major research-oriented pharmaceutical company with leading products in theareas of women's health care, cardiovascular disease therapies, cent...

Abgenix Reports Encouraging Preclinical Results With ABX-EGF In Cancer Research

...conditions, including transplant-related diseases, inflammatory andautoimmune disorders, cardiovascular disease and cancer. Abgenix has developedXenoMouse technology, which it believes enables quick generation of highaffinity, fully human antibody product candidates to essentially any diseasetarget appropriate fo...

Studies At Cedars-Sinai Confirm Identity Of An Elusive 'Receptor' In Human Cells -- A Breakthrough In Understanding, Fighting Septic Shock

... types, including the white blood cells to produce inflammatory moleculescalled cytokines. Cytokines destroy invad...hich turns on genes thatmake cytokines and trigger inflammatory responses. In humans, one of the cellsurface receptors that pass signals to NF-kappa B is the recept...

Molecular Effect Of Vitamin E On Plaque Formation Identified

...ting evidence suggests that plaque formation is an inflammatory process,"Devaraj said. This enzyme, 5-lipozygenase, produces a substance that stimulatesthe release of the protein interleukin-1beta (IL-1beta), which promotes plaqueformation. Studies have shown it stimulates adhesion of white blood cells ormonocyte...

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