JCI table of contents September 15, 2004
...ween the number of genes involved and the variable inheritance patterns, identifying all the mutations that could cause disease is a daunting task. Now David Thorburn and colleagues, from Murdoch Childrens Research Institute, have developed a methodology that takes a "Venn Diagram" approach to efficiently pinpo...Venn diagram tactics to vet complex disease
...ween the number of genes involved and the variable inheritance patterns, identifying all the mutations that could cause disease is a daunting task. Now David Thorburn and colleagues, from Murdoch Childrens Research Institute, have developed a methodology that takes a "Venn Diagram" approach to efficiently pinpo...New genetic hypothesis for the cause of autism
...articipate with the Angelman gene in an oligogenic inheritance model. The researchers reviewed available evidence...le, from evidence that maternal, but not paternal, inheritance of extra material from chromosome 15 causes autism in a small fraction of cases, they suggest that t...New technique helps scientists reveal interactions between genes and drugs
...me. Scientists already know a great deal about inheritance of genetic markers among the cell lines. This enabled Washington University researchers to compare and contrast the genetics of a cell line with altered sensitivity to cell lines from other family members and from multiple generations of the same fam...LICR/UCSD team solves mystery of centromeres
..., leading to proper cell division and the faithful inheritance of genes. Published in the July 29, 2004 issue of the journal Nature , the study utilized a sophisticated new form of mass spectrometry developed at the UCSD School of Medicine to determine how a protein called CENP-A, turns the normally flexi...Study by Tufts biologist provides window into progression of some degenerative diseases
...expansion during sperm development, which leads to inheritance of even longer repeats in the resulting children a... proteins, could be very useful in controlling the inheritance and severity of the repeat expansion diseases. "Freudenreich's study is an example of the innovative...Pump failure implicated in a form of dystonia
...ithin the chromosomal region known to be linked to inheritance of the disease. The researchers pinpointed mutations in one particular gene, called ATP1A3, as common in all the families. This gene is the blueprint for a protein that is a key catalytic subunit in a larger enzyme that pumps sodium and potassium acr...March of Dimes awards $250,000 prize to pioneering scientist
... of Dimes. "This was the key to understanding the inheritance pattern of X-linked disorders such as hemophilia, Duchenne muscular dystrophy, fragile X syndrome, and certain types of cancer. As a result of Dr. Lyon's work, it became possible to provide accurate tests and genetic counseling for families affected...Fox Chase Cancer Center research reveals how COX-2 causes ovarian cancer
...ertain type of bowel cancer. The important role of inheritance has led many women with a family history of breast or ovarian cancer to have their breasts and ovaries removed as a means of preventing the development of cancer. Xu and his colleagues studied the tissues removed during prophylactic oophorectomy (re......rt stretch of peptide repeats was required for the inheritance of prions - the proper division of prion masses an..., of prions. These results help explain why stable inheritance of prions is rare; while many proteins have stretches of amino acids similar to the aggregation sequ...Genome of first fungal pathogen unveiled
...DNA base pairs, the fundamental building blocks of inheritance -- will further simplify the task of deciphering genes and their functions, he added. The genomes of other important fungal pathogens can include as many as 200 million base pairs, more than 20 times that of the Ashbya genome. In comparison, the gene...Research adds health benefit to tomatoes
...ished the feat through the characterization of the inheritance pattern of a little studied gene in tomatoes called "anthocyanin fruit," or Aft. Myers and his OSU graduate students crossed a domestic tomato plant with a genetic stock of tomato that included a gene incorporated from a wild relative with anthocyani...Study of dyslexic brain finds three word forms responsible for reading success
...ophisticated and powerful new methods to model the inheritance patterns and map genomic locations of genes involved in dyslexia, the researchers are drawing on genetic material gathered from 111 families with a total of 898 members. "A variety of molecular genetic approaches have been taken to locate genes for ...New study suggests brains of autistic children can be trained to recognize faces
...e to the disorder. "There is strong evidence that inheritance is a major player in autism," said Schellenberg. "We are using autism as a trait and trying to do a genetic map that will help us to understand whether the deletions we see in autism are affecting genes and causing autism, or whether the genome in au...Dyslexics not doomed to life of reading difficulties
...Learning Disabilities Center's effort to model the inheritance patterns and to map the location of genes involved in dyslexia. This multi-generational study of 111 families with at least one dyslexic child involves genetic material from 898 individuals. "While we hope to identify more locations where reputed g...'Ageing gene' could be passed on via X chromosome
...s and sons or between spouses. In other words, the inheritance of a parental X chromosome (from mothers for sons,...ents and children. Dr Staessen comments: "X-linked inheritance of telomere length is the most probable explanation for our findings. Pending confirmation, our obse...Genes influence memory in families with Alzheimer's disease
...ology. Located in DNA and RNA, a gene is a unit of inheritance that determines one or more traits. "These results are exciting because if we can identify the genes that are responsible for memory, they may lead us to identifying more of the genes that contribute to Alzheimer's disease," said study authors Joseph...The dopamine receptor D1 gene and ADHD: A piece of the genetic puzzle?
... ADHD. To test this, the authors investigated the inheritance patterns of four DNA changes (situated at various positions across the DRD1 gene) in a large sample of small families, each having at least one child diagnosed with the disorder. These children were more likely to have inherited one particular combin...Natural selection in a nutshell
...volve or change is often limited because measuring inheritance in the wild is difficult. Boutin was able to address this issue because he has been monitoring a large squirrel population--approximately 400 adults--since 1989 and because he was able to take some squirrels away from one mother and give them to anot...University of Chicago scientist wins prestigious Balzan Prize
...Angela Lina Balzan who, coming into a considerable inheritance on the death of her father, Eugenio Balzan, decided to use the money to honor his memory. Eugenio Balzan was a leading Italian journalist, managing director and shareholder of the daily newspaper Corriere della Sera. He died in 1953 in Switzerland af...