Tag: "inherited" at biology news

New molecular link key to cellular proteins involved in cancer progression, other diseases

...that does not involve DNA sequence and that can be inherited from one generation of cells to another. Along with ubiquitination, epigenetic modifications also include histone methylation, acetylation and DNA methylation. "The PcG silencing system is one of the best-studied model of epigenetic regulation system...

Key cell-death step found

...The work could provide insights on two devastating inherited diseases. In healthy cells, mitochondria (tiny en... diseases: dominant optic atrophy, the most common inherited cause of blindness, and Charcot-Marie-Tooth disease, which reduces sensation in the feet, lower legs...

Information system to help scientists analyze mechanisms of social behavior

...or social behavior is that DNA is both genetically inherited and environmentally responsive." BeeSpace was one of six awards totaling $30 million announced today (Sept. 16) as part of the NSF's Frontiers of Integrative Biological Research (FIBR), a program now in its second year. BeeSpace will be housed in the...

JCI table of contents September 15, 2004

... some that are found in the mitochondria, and thus inherited through the mother, and some that are found in the nucleus and are inherited from both the mother and the father. Between the number of genes involved and the variable inherita...

Venn diagram tactics to vet complex disease

... some that are found in the mitochondria, and thus inherited through the mother, and some that are found in the nucleus and are inherited from both the mother and the father. Between the number of genes involved and the variable inherita...

Protein is key to fatal disorder and normal cell function

...cow disease. Batten disease collectively refers to inherited disorders also called the neuronal ceroid lipofusc... by mutations in the CLN3 gene, is the most common inherited neurodegenerative disease of childhood. Children who inherit a copy of the defective CLN3 gene from ...

Genetic analysis rewrites salamander's evolutionary history

...ose needed to produce energy for the cell. They're inherited without recombination from the mother, and therefore represent an unbroken female chain going back perhaps 100-150 million years in plethodontid salamanders. By looking at mutations in the mitochondrial DNA, biologists can infer the pattern of evolut...

Disruption of protein-folding causes neurodegeneration, mental retardation

...angliosidosis is a lysosomal storage disorders, an inherited disease in which one or more enzymes in the lysosomes are defective. Lysosomes are the cell's recycling centers, where proteins, fats and other molecules are broken down into their basic building blocks, which are then reused to make new molecules. L...

Researchers discover why mutant gene causes colon cancer

...researchers identified the APC gene, as well as an inherited colon cancer predisposition known as familial aden...t occurs in people who have APC mutations. In this inherited syndrome, hundreds to thousands of pre-cancerous growths called adenomatous polyps form in the colon...

Adaptive changes in the genome may provide insight into the genetics of complex disease

...nk more cow and goat milk. The result: people that inherited certainvariations of these genes, known as alleles, are better able to absorbcalcium into their bodies. One of the genes involved is TRPV6 and has been implicated in thedevelopment or aggressiveness of prostate cancer. It and another gene in theregio...

New genetic hypothesis for the cause of autism

...mixed epigenetic and genetic and mixed de novo and inherited (MEGDI) model. Their hypothesis, and evidence to support it, will be published September 8, 2004 in the online edition of the American Journal of Medical Genetics Part A, and will be available via Wiley InterScience at http://www.interscience.wiley....

UCLA molecular biologists uproot the tree of life

...nown where eukaryotes came from before. Eukaryotes inherited two sets of genomes from very different prokaryotes." One prokaryote ancestor branches from deep within an ancient photosynthetic group of microscopic single-celled bacteria called the proteobacteria. The group is primarily photosynthetic, but today ...

New genetic research demonstrates possible cause of inherited form of Parkinson's disease

...researchers have identified a possible cause of an inherited form of Parkinson's disease, which may be related ...of Parkinson's disease is unknown, a few cases are inherited and can be traced to mutations in four different genes, including the alpha-synuclein gene. This is...

Breakthrough in understanding of hereditary disease of lymphatic vessels

...s from damaged or absent lymphatic vessels, may be inherited or may be a side-effect of the surgical removal of tumors. Lymphatic vessels normally remove fluid and proteins escaping from blood capillaries into surrounding tissues, and lymphedema is characterized by the disabling swelling of legs, and sometimes...

New clues to hereditary blinding disease found

HANOVER, NH Seeking a cure for an inherited disease that causes blindness in over one million people worldwide, Dartmouth Medical School researchers have discovered a critical role for zinc in retinitis pigmentosa. The amount of zinc, a trace metal naturally absorbed by the body, can determine...

Retroviral gene therapy? ASLV, HIV, and MLV show distinct target site preferences

Many diseases (including inherited disorders like cystic fibrosis to cancer) have a genetic component and gene therapy holds the promise of restoring compromised genes with their healthy counterparts. That promise was quashed when a teenager -- Jesse Gelsinger -- suffering from a rare...

Scientists suggest framework for epigenetics in common disease

...and haplotypes [lengthy genetic sequences that are inherited in blocks], we need to examine multiple samples from different tissues and different people to establish 'epigenotypes,'" says Feinberg. "Only by superimposing genetic and epigenetic information will we get a complete picture of how genes' functions ...

Location of potential familial lung cancer gene discovered

...26, 2004 -- Researchers have discovered a possible inherited component for lung cancer, a disease normally asso...all amount can lead to cancer for individuals with inherited susceptibility. The researchers also plan to continue screening additional families who co...

Study by Tufts biologist provides window into progression of some degenerative diseases

... Tufts University study has shed light on how some inherited diseases such as Huntington's and muscular dystrop...ic instability and their relationship with certain inherited diseases," said Susan Ernst, dean of the School of Arts and Sciences at Tufts and a professor of bio...

Researchers in UGA Vet School discover a mechanism that blocks replication of a retrovirus

...NA to reside in the host genome permanently and be inherited by offspring. These so-called "endogenous retroviruses" are usually harmless and cannot orchestrate production of infective virus particles. "Every sheep on the planet has endogenous retroviruses that are present in the genome like every other gene,...

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