Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
...has provided evidence that lycopene may be able to inhibit the growth of prostate tumours and that its effect may be enhanced if it is combined with vitamin E. A number of epidemiological studies have already indicated that high intake of lycopene a carotinoid that gives the red colour to tomatoes and othe...Wisconsin scientists develop quick botox test
...creen for millions of chemicals to see which might inhibit the paralyzing effects of the toxin, according to ...say has the potential to reveal molecules that may inhibit various toxin action pathways." Botulinum toxin is made by a bacterium that causes food poisoning. ...A novel, safer strategy for regulating gene expression
... Next, they identified two compounds that strongly inhibit ribozyme self-cutting, and showed that they could be used to turn on ribozyme-containing genes in mammalian cells, inducing the cells to make the desired protein. Finally, they proved that the technique works in live animals. They introduced the gen...Research suggests new avenue for stopping, preventing colon cancer
...rst evidence that blocking a cellular receptor can inhibit the development of pre-cancerous colon polyps in m...ncer Cell, the scientists reported that they could inhibit polyp development in mice by "knocking out" the PPARdelta gene. PPAR stands for peroxisome prolifera...New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
...45;, stimulates tumor growth faster than TRAIL can inhibit it. "Our results suggest that is it possible to use NF-kB or TNFα inhibitors to prevent inflammation-induced tumor growth, thus destroying their advantage, and allowing TRAIL to tip the balance in its favor," Luo said. The study builds upo...Tips from the Journals of the American Society for Microbiology
...and oregano extracts combined with lactic acid may inhibit the growth of bacteria in meat and fish say researchers from Massachusetts. Their findings appear in the September 2004 issue of the journal Applied and Environmental Microbiology. Listeria monocytogenes, the cause of many f...JCI table of contents September 15, 2004
...on-steroidal anti-inflammatory drugs, which act to inhibit the action of COX. Two prostenoids called PG I2/prostacyclin (PGI2) and thromboxane A2 (TXA2), are ele-vated in individuals with atheroscle-rosis, but their roles in the initiation and development of atherosclerosis remain ill-defined. To investigat...Picking prostanoids to provide protection
...on-steroidal anti-inflammatory drugs, which act to inhibit the action of COX. Two prostenoids called PG I2/prostacyclin (PGI2) and thromboxane A2 (TXA2), are ele-vated in individuals with atheroscle-rosis, but their roles in the initiation and development of atherosclerosis remain ill-defined. To investigat...A liking for sweets, combined with novelty seeking, may predict alcoholism
...lects an individuals inability or unwillingness to inhibit behavioral responses in the face of impending punishment in alcoholics. Novelty seeking has been frequently found to be higher in alcoholics, compared with nonalcoholic control subjects, as well as in patients with a familial form of alcoholism, c...Gene expression in liver tumors and patient prognosis
...thors conclude. "For example, small molecules that inhibit activities of some transcription factors are already available and may provide opportunities to alter the course of HCC progression in both subclass A and B." An accompanying editorial by Joseph Locker, M.D. of Albert Einstein College of ...New research suggests early diet may play key role in protecting against childhood leukaemia
...ect against leukaemia in a variety of ways it can inhibit the mutagenicity of cigarette smoke polycyclic aromatic hydrocarbons, radiation induced chromosome damage and it can prevent the formation of harmful heterocyclic amines and nitroso-compounds which can result from eating certain processed foods. He h...Optimizing protein's 'death domain' halts leukemia in laboratory study
...no acids on anti-death molecules such as BCL-2 and inhibit their activity. BCL-2, a key part of the apopotosi..." says Walensky, "and these new molecules directly inhibit a protein interaction that we're interested in. The potential is that you could take any alpha helix...Molecular staples shape a cancer killer
...aled that SAHB could enter, and, more importantly, inhibit the growth of those cells. "When we saw that we could activate cell death in a specific way in whole cells, we were eager to conduct animal studies," said Walensky. So, the researchers tested the effects of SAHB on mice that harbored human leukemia ...Highlights of American Chemical Society national meeting in Philadelphia, Aug. 22-26
... Personal Care Products.) Measles: Compounds that inhibit virus could help close vaccination gap -- Measles... In laboratory studies, the non-peptidic compounds inhibit the measles virus and block the virus from entering cells. Although further testing is needed, the r...University of Pittsburgh receives $10 million grant for head and neck cancer
... targeting STAT signaling, the researchers hope to inhibit the progression of head and neck cancer. Albert DeLeo, Ph.D., professor of pathology, and Robert Ferris, M.D., Ph.D., assistant professor of otolaryngology, will head up an additional project to develop a therapeutic vaccine that targets the tumor-s...Tiny molecules have big potential as cancer drugs, Stanford researcher believes
...ing an inhibitor requires knowing which protein to inhibit and what the protein does. Finding out the latter is a particularly difficult task in the case of cathepsins because of the nature of proteases, Bogyo said. "Proteases take other proteins and degrade them into little bits, and so it's hard to figure ...Synthesized molecules studied as weapon to stop cell division in cancer cells
...h researchers who are designing small molecules to inhibit Pin1 are seeing promising results with a small U-s...is good if it's a cancer cell. "It makes sense to inhibit the Pin1 enzyme," said Etzkorn. Protein shape determines biological function. Pin1 works by changin...Study suggests cell-cycle triggers might be cancer drug targets
... with drugs that would be designed specifically to inhibit them," Sicinski says....X marks the spot: Vector insertion is viral specific
...on," says Bushman. "The clearest way forward is to inhibit the catalytic activity of the integrase protein and some of our future work is geared toward that." These are still early days in harnessing knowledge about viral integration in humans to make safer and more effective gene therapies, let al...Marijuana ingredient inhibits VEGF pathway required for brain tumor blood vessels
...ids which, in previous studies, have been shown to inhibit the growth of blood vessels, or angiogenesis, in laboratory mice. However, little was known about the specific mechanisms by which cannabinoids impair angiogenesis, or whether the chemical might do the same in human tumors. To answer the first part ...