Tag: "inhibitors" at biology news
Harvard, Duke Researchers Discover 'Off-switch' Inside Human Cells
... a better positionto design selective and specific inhibitors
or enhancers of the process."...
Chemists Compute Answers To The Origin Of Gout
...s detailed analysis should help the development of inhibitors
for the illness. The Computational Chemistry Group uses the latest computer tools to probe and model complicated chemical changes. The rapid advances in computer technology mean that many of today's chemists design new molecules on a computer scre...
Genetic Trickery Offers New Way to Target HIV
...her therapies, Rosenblatt says. Currently,protease inhibitors
prevent the maturation of virus that hasalready infected cells, and reverse transcriptase inhibitors
like AZT and Nevirapine prevent the virus from replicating withincells. The new work involves a thir...
Vertex Pharmaceuticals Researchers Report Three-Dimensional Structure Of Hepatitis C Helicase Enzyme; Report In Structure
...ructural information to designhepatitis C helicase inhibitors
as new antiviral drugs to treat hepatitis Cvirus (...iplinary effort underway toidentify small molecule inhibitors
of HCV protease. In 1997, Vertex entered acollaboration with Eli Lilly & Co. to design and develop c...
Salve From Serpents? UD Studies May Explain Why Viper-Venom Protein Stops Tumor Spread In Mice
...ntegrins, McLane explains.Disintegrins are "potent inhibitors
of platelet aggregation and cell adhesion,"and therefore prevent an early step in blood clotting, Niewiarowski says. Onceinjected into a victim's bloodstream, disintegrins from viper-snake venom stopthe sticky protein, fibrinogen, from binding with p...
Hultgren Receives Prestigious Eli Lilly Award
...grensays. The researchers also are testing inhibitors
of the chaperone protein.Without this essential link in the assembly line, E. coli cannot make pili andtherefore can no longer colonize the urinary tract or cause disease. Theinhibitors therefore may prove useful as antibiotics against bacteria thata...
Over 4700 Technical Sessions Will Reveal New Findings At National Chemists' Meeting In Dallas, March 29 - April 2
...d to monitor cancer therapy Naturally occurring inhibitors
of HIV Three years of NAFTA and its impact on the chemical industry Roles and accomplishments of women and minorities in chemistry Chemical patents related to chocolate and toys Tributyltin compounds in the aquatic environment Causes o...
Heart and Soul: The Blood Vessels And Brain Use Common Guide
...aling, and cancer. Buoyedby hope that angiogenesis inhibitors
and promoters may one day yield treatmentsfor tumors and heart disease, the field is attracting increased attention frombasic researchers trying to understand this fundamental process. The secondfield, axonal guidance, has taken on the herculean task...
Rapid Progress Reported On New Class Of Anti-Cancer Drugs
... on thebiology of FTase inhibitors. The first such inhibitors
were sulfur-containingthiol compounds, which mimic...t likely to triggerimmune-related toxicity, so new inhibitors
are being designed without thiols. Daniele Leonard, of Parke-David Pharmaceutical Rese...
Structure Of Tumor Necrosis Factor-Alpha-Converting Enzyme Solved - Milestone Toward Rational Drug Design For Rheumatoid Arthritis And Endotoxic Shock
...s. Due to TACEs role in TNF a conversion, inhibitors
of TACE would affect the release of soluble TNF...ecific synthetic TACE inhibitors. Such tailored inhibitors
could act as effective therapeutic agents against arthritic lesions and might increase the rate ...
New Look At How Cells Move Could Shed Light On Tumor Growth
...cells by time-lapse videomicroscopyshowed that the inhibitors
tightened adhesion properties in hamster ovariancells and thwarted the tail's ability to let go. Previous research hadfound higher calcium levels at the rear of a cell, suggesting a possibleregulatory role. In a paper accepted for publication in th...
Study Finds Russian Women, Children Not Getting Enough Iron In Their Diets
...r said. "When corrected forintake of enhancers and inhibitors
of iron absorption, the estimated absorbableiron was less than .5 milligrams a day. Consumption of inhibitors
in grainproducts, tea and other foods results in up to 58 percent loss of otherwiseavailable iron." ...
Scientists At The Scripps Research Institute And R.W. Johnson Pharmaceuticals Develop New Antibacterial Agents
...WJ-49815 and itsderivatives as the first series of inhibitors
of two-component systems withdemonstrated bacteric...croorganisms. Thescientists are hopeful that these inhibitors
targeting the signal transductionmechanisms will be useful new tools in the armamentarium against in...
Inhibitor Shows Potential To Protect Infant Brain
...e exploring the idea that compounds called caspase inhibitors
might minimize the brain damage that results from ...ether it would be clinically useful to use caspase inhibitors
to prevent apoptosis," Holtzman says. "So we tested the potential of a compound called BAF." BAF ...
Different Molecular Events Underly Experience-Dependent Loss And Gain Of The Function Of The Developing Brain
...f the growing structures. By applying inhibitors
against different proteases into the cortex, Mller... gain of function. By using a variety of different inhibitors
it is shown that a cascade of two proteases is essential for brain plasticity. These pr...
Neurons Control Brain Immunity: Neurotrophins As Regulators Of Antigen-Presentation In Microglial Cells
... action on microglial cells, as both, inhibitors
of neuronal signalling as well as glutamate, did not show any activity in the absence of neuronal cells. Further experiments addressed the question which nerve cell derived mediator could be involved in the act...
Boosting Immune Response Against HIV-1 Key To Controlling Infection, Say University Of Pittsburgh Researchers
...revious studies have shown that combining protease inhibitors
with tworeverse transcriptase inhibitors
does not completely eliminate HIV from thebody, nor does triple therapy offer patients full protecti...
Researchers Document Transmission Of Protease-Resistant HIV
...enters for Disease Control andPrevention Protease inhibitors
have been approved for two years, and as part of t...o a dramatic decline in AIDS deathrates. Protease inhibitors
block construction of proteins the virus needs tobuild more copies of itself. Transmission of drug r...
HIV-Positive Injection Drug Users Often Don't Receive Protease Inhibitors And May Not Be Aware Of The Drug
...cisco who are HIV-positive do not receive protease inhibitors
and maynot even be aware of these medications--des...individuals (25 percent) had ever receivedprotease inhibitors
and only nine of them (14 percent) were still receiving themedications. Most of the indivi...
Ecological Consequences Of Jasmonate-Induced Responses For Plants In Native Populations
... inducible chemical responses, such as protease inhibitors
which slow herbivore growth by reducing their digestive efficiency, may only function as defenses in nature when expressed in concert with other responses, such as the induced alarm calls of plants that increase the vulnerability of the h...
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