Cannabis may help combat cancer-causing herpes viruses
... The USF researchers suggest that THC selectively inhibits the spread of gamma herpes viruses by targeting a gene these viruses all share called ORF50. Dr. Medveczky emphasized that more studies are needed. "We have not evaluated the effect of THC in an animal model yet so we do not recommend people start u...16th EORTC NCI AACR Symposium 'Molecular Targets and Cancer Therapeutics'
...ueline Limpens: Study shows lycopene and vitamin E inhibits growth of prostate tumours in mice, underpinning epidemiological evidence. Phase II trial in patients now under way. * Dr. Olivier Feron: A revolutionary approach to angiogenesis - exploiting tumour blood vessels to boost chemotherapy and radiotherap...New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
... in response to inflammation, NF-kB takes control, inhibits cell death and promotes cancer growth. When NF-kB or TNFα were inhibited, however, TRAIL was able to strongly assert its ability to reduce tumor growth by killing cancer cells. The role of TRAIL was further illustrated in additional experiments...JCI table of contents September 15, 2004
...rk that indicated that low doses of aspirin, which inhibits TXA2 more than PGI2, has been used as anti-platelet therapy for the prevention of myocardial infarction and recurrence of strokes. TITLE: Roles of thromboxane A2 and prostacyclin in the development of atherosclerosis in apoE-deficient mice AUTHOR CON...Picking prostanoids to provide protection
...rk that indicated that low doses of aspirin, which inhibits TXA2 more than PGI2, has been used as anti-platelet therapy for the prevention of myocardial infarction and recurrence of strokes....New research suggests early diet may play key role in protecting against childhood leukaemia
...oods. He has also shown that curcumin irreversibly inhibits the multiplication of leukaemia cells in cell culture. Nagabhusan says these results are confirmed in humans. Dr Marilyn Kwan of the University of California, Berkeley will be presenting the results of another study looking at the effects of food o...Final Alert: 16th EORTC NCI AACR Symposium
...argeting TRAIL R2 protein Lypcopene and vitamin E inhibits prostate tumours new laboratory results underpin epidemiological evidence patient trial now started International trial finds acne-type side effect predicts effectiveness of new targeted treatment Laboratory tests show gossypol abandoned as a co...Single isolated mouse skin cell can generate into variety of epidermal tissues
... cells in a holding pattern -- an environment that inhibits growth -- and that is why they have been recognized as slow cycling," says Lowry. After expanding an isolated stem cell clone several million times, the researchers grafted the cells on to the back of a mouse that had no hair, and demonstrated that t...Diabodies act as guided missiles targeted to mammary tumor growth
...ing radioisotope yttrium-90, C6.5K-A significantly inhibits the growth rate of human breast tumor xenografts in mice. "The diabodies bound to the HER2 receptor produced by certain breast tumor cells." said Adams, the lead author on the paper. "Imaging indicated that the diabody was concentrated in the mammar...Purdue study finds antioxidant protects metal-eating plants
...idopsis containing the SAT gene to a compound that inhibits their ability to make glutathione. When grown on nickel, these plants also suffered high levels of oxidative damage, just like their normal counterparts. "This confirms that it really is glutathione that's responsible for nickel tolerance," Freeman ...JCI table of contents: 1 September, 2004
... evidence that JAM-A is involved in a process that inhibits dendritic cells trafficking to the lymph nodes and the activation of specific immune responses. TITLE: Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A-deficient mice AUTHOR CONTACT: Elisa...Other highlights in the September 1 JNCI
...lated pathway in glucose-deprived cancer cells and inhibits tumor growth in mice, according to a new study. Tumors can become glucose- and oxygen-deprived when they lack blood vessels, which transport these molecules. Cells deprived of glucose accumulate unfolded proteins, but such cells survive this stress...APS awards more than $140,000 to minority students of physiology
...ab has discovered that activation of Wnt signaling inhibits differentiation of fat cells and prevents obesity in mice. Currently, she is testing whether Wnt signaling results in fewer fat cells and more bone forming cells in the marrow cavity. This work may provide a new target for preventing the bone loss a...Synthesized molecules studied as weapon to stop cell division in cancer cells
...ill of Pin1. The research team discovered that cis inhibits the Pin1 enzyme's function 23 times better than tr... Center. The poster, "PhosphoSer-cis-Pro isostere inhibits Pin1 23-fold better than the trans-Pro isostere," by Etzkorn, PhD. student Xiaodong Jane Wang, post-...Anticancer drug zebularine specifically targets tumor cells
...LES, August 23, 2004 A novel anticancer drug that inhibits a process known as DNA methylation is preferentially taken up by tumor cells as compared to normal cells, according to a group of researchers led by scientists from the Keck School of Medicine of the University of Southern California. In addition, th...... a protein called cryptochrome, which subsequently inhibits the ability of Bmal-1 to activate cryptochrome's own transcription. This feedback loop is what keeps the body entrained to a 24-hour day. Since Bmal-1 is so crucial to keeping the body's clock entrained, finding something like Rora, which alters B...Other highlights in the August 18 JNCI
...dicates that RET stimulates cell proliferation and inhibits apoptosis. The authors suggest that RET signaling should be investigated further as a target for new therapies for the disease. Contact: Grit Haberer, University of Rostock, 49-381-494-5066, grit.haberer@med.uni-rostock.de Also in the August 18 JN...Body's own defense against H. pylori, cause of stomach ulcers and stomach cancer
...a, Ph.D., has discovered that a human glycoprotein inhibits Helicobacter pylori ("H. pylori"), the bacterium that causes stomach ulcers and is linked with 90% of stomach cancers. Published on August 13th in Science magazine, these results present a new way of looking at treating chronic inflammation associa...Blood pressure hormone may inhibit growth of lung cancer
... provide the first evidence that angiotensin-(1-7) inhibits the proliferation of human lung cancer cells," they said. They hypothesized that the hormone serves as a natural regulator of cell growth, both by reducing the rapid proliferation of cells common in cancer and by increasing cancer cell death. Gal...FDA approves VYTORIN, first and only to powerfully reduce LDL cholesterol through dual inhibition
...ance of cholesterol from the bloodstream. VYTORIN inhibits absorption of cholesterol in the small intestine, while also reducing cholesterol synthesis in the liver leading to clearance of cholesterol from the bloodstream. Indications and contraindications for VYTORIN VYTORIN is indicated as adjunctive the...