Tag: "initiating" at biology news

UCSF-Led Team Offers New Insight Into Neurological Basis Of Dyslexia

...ounds are destined to have difficulty successfully initiating reading.Other behavioral studies have indicated that most people with dyslexia,characterized by a difficulty with reading, also have impairments in thefidelity of their auditory reception. However, because most dyslexicsultimately develop facile spe...

University of Pittsburgh Medical Center performs first in vivo gene therapy for hemophilia A

...g-term production ofcirculating FVIII. We are now initiating testing in humans; an importantmilestone for Chiron," said Lewis (Rusty) T. Williams, Ph.D., M.D., Chiron'schief scientific officer and president of its research and development group. The hemophilia in vivo gene therapy employs a retroviru...

Head trauma damages DNA repair mechanism

...he specificpathways for recognizing DNA damage and initiating the DNA repair process," sayssenior author Tracy K. McIntosh, PhD, professor of neurosurgery, bioengineering,and pharmacology and director of Penn's Head Injury Center. McIntosh andcolleagues report their findings in the current issue of the Journal ...

NCAR scientists seek clues to wildfires during Alaska prescribed burn

...t of Fairbanks, Alaska. As of July 7, thechance of initiating the burn on July 8 is very likely at 75%probability. The U.S. Department of Agriculture's Forest Service issponsoring the experiment, called Frostfire. NCAR's primary sponsor isthe National Science Foundation. "There are still a lot of unanswered que...

Cellular espionage at play in post-menopausal osteoporosis

...s increase inbone cells, preventing cytokines from initiating the path of bone destruction. Without estrogen, signaling receptor proteins flourish and the decoys diminish,letting the osteoclasts erode bone. The results were published in the May 15, 1999, issue of the Journal of ClinicalInvestigation. The resea...

MGH researchers first to identify genetic malfunction in type 1 diabetes

...se mice reach a certain age, therefore most likely initiating their diabetes." Type 1 diabetes (also called juvenile or insulin-dependent diabetes) is an autoimmune disease in which the immune system mistakenly attacks the insulin-producing beta cells of the pancreas. Normally, immune system components called...

'Frozen pictures' allow far-reaching glimpse into the cells protein factory

...ze. It is on 30S - the smaller subunit critical to initiating protein biosynthesis and decoding genetic information, that Yonath set her sites. More specifically, she wanted to capture "snapshots" of 30S in its "active form" - during the precise moment in time when protein biosynthesis begins. To do so, her tea...

Abgenix initiates phase III clinical trial of graft versus host disease therapy

...December 7, 1999 - Abgenix, Inc. (Nasdaq: ABGX) is initiating a Phase III clinical trial comparing its antibody, ABX-CBL, with standard therapy for patients with steroid-resistant graft-versus-host disease (srGVHD), a serious, life-threatening disorder. Abgenix also indicated that it would seek a corporate part...

Targeted Genetics presents advances in synthetic gene delivery technologies

... combination regimen and support the rationale for initiating clinical trials using tgDCC-E1A in combination with paclitaxel and cisplatin. Combination regimens may provide therapeutic benefit to a larger population of patients whose disease does not respond to stand ard treatments. Targeted Genetics inte...

Mouse embryo hints at how mammalian body forms

...ves into high gear with the onset of gastrulation, initiating a major shift in the arrangement of its cells. Cells begin migrating out along an invisible axis, forming two poles, signifying the future head and tail regions. From there, cell migration continues to form the front and back and ultimately to gener...

Study links two important cellular systems; increases prospects for new drugs for cancer, heart disease

...ecular complexes necessary for initiating gene expression. Others, however, play a ... with their target DNA in the nucleus, initiating a gene response. The TGF-beta pathway is a key system in biology and illness. I...

ASM statements on FY 2001 federal budget proposal: NIH, CDC, NSF

...save lives. The Administration deserves credit for initiating funding for bioterrorism preparedness and response over the past two years. The ASM recommends that Congress provide additional funding for the CDC bioterrorism preparedness and response program to enable more states and cities to be protected. A...

Possible cause and treatment for shock uncovered by UC San Diego bioengineers

...elease dangerous activators into the blood stream, initiating a cascade of events leading to multiple organ failure." To test their theory, the researchers surgically produced shock in rats. Control rats were given no treatment. But the researchers injected a broadly acting pancreatic enzyme inhibit...

Cell division study aids cancer drug search

...es a complex of proteins* which activate E2F, thus initiating celldivision. But if these control proteins are faulty and E2F is over-activated, excessivecell division takes place. This can lead to cancer. "This is an important breakthrough" says Professor La Thangue, "because by understanding the natural mech...

Weight training helps to maintain good health, study finds

...es in the muscle begin within two to four weeks of initiating resistance training, far earlier than previously thought. What's more, Staron found that muscles appear to respond to even limited weight training - he noted significant changes in the thigh muscles after just four workouts. Staron, an avid weight l...

Different levels of transcription factor coax immune cell progenitors down different developmental pathways

...e genome, it can activate or repress genes thereby initiating a new developmental program. Researchers have shown that developing fruit flies use graded levels of certain transcription factors to control the generation of different embryonic cell types, but there hasn't been strong evidence for this mechanism i...

Targeted genetics presents promising data from cystic fibrosis clinical trial

...ship with Targeted Genetics and we look forward to initiating the upcoming Phase II trial," said Bonnie Ramsey M.D., Director of the CFF TDN. "We appreciate the commitment that Targeted Genetics has made to conduct gene therapy research for the future benefit of individuals with CF. The Company has paved the w...

Plant's PICKLE gene may hold clue to cancer

...development of characteristics for a mature plant, initiating root and shoot development. At the same time, the plant with the normal PICKLE gene produces a protein called chromatin remodeling factor, which flips the biochemical off-switch that stops the expression of embryo characteristics. The two switches op...

Millennium's LDP(PS)-341 inhibits growth and induces death of cancer cells, appears to overcome chemotherapy resistance

...emotherapeutic agents. Millennium is committed to initiating additional studies in multiple myeloma in the coming months." In addition to the studies discussed at the ASH meeting, the National Cancer Institute (NCI) is conducting an extensive program of LDP-341 clinical trials under a Cooperative Research an...

Immunoprivilege has its disadvantages

...e could be exacerbated depending on the underlying initiating event....

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