Tag: "initiating" at biology news

Rockefeller researchers identify defense system in plants

...itor their environment for signs of dryness before initiating growth. Furthermore, they have identified a specific protein as a key player in the process. The findings, reported in the April 3 issue of the Proceedings of the National Academy of Sciences (Early Edition #14), are of immediate interest to agricu...

Aspirin targets key cell that triggers organ rejection and other immune responses, report University of Pittsburgh researchers in journal article

...erful immune system cells that are responsible for initiating an immune response -- by preventing their maturation and hence, their ability to signal other cells to attack. The findings help to explain why aspirin taken in high doses significantly reduces inflammation and provides relief to patients with vari...

Penn researchers explore the role of cell suicide in the development and treatment of cancer

...ole of two pro-apoptotic proteins, Bax and Bak, in initiating apoptosis. This new work demonstrates that cells lacking Bax and Bak cannot be killed by either chemotherapy or irradiation. It also demonstrates conclusively what scientists have suspected for several years: that chemotherapy and irradiation work ...

Penn study findings reverse key chronology for development of Alzheimer's disease

...s is the belief that amyloid plaques constitute an initiating factor in the onset of Alzheimer's Disease. Pratico and his colleagues decided to establish whether that is true. They discovered that free radicals show up even earlier on the scene. The scientists studied mice that had been engineered to produce am...

Changing colors in mice

...c operator, thereby preventing RNA polymerase from initiating transcription. When the lactose analog IPTG is present, the lac repressor protein binds IPTG and undergoes a conformational change that decreases its affinity for the lac operator and allows for transcription to occur. Dr. Scrable and colleagues ha...

Scientists find genetic basis of insect's resistance to engineered crops

...n the moths. But, the authors add, "any delay in initiating BtR-4 allele monitoring erodes the opportunity to make informed modifications to the high-dose/refuge strategy, that could sustain use of Bt-transgenics and prolong the environmental benefits they bring by reducing the use of conventional insecticide...

Study detailing safety and efficacy of exisulind in treating recurrent prostate cancer

...ered the extension study, with 33 placebo patients initiating exisulind therapy and 27 patients continuing on exisulind. "We are pleased that Cell Pathways is developing their innovative technology for the treatment of prostate cancer," said Hank Porterfield, chairman of the board of US-TOO. "Men with prostat...

Women with rare lung disease found to also have high prevalence of meningiomas

...ne replacement therapy could have played a role in initiating the tumor or fueling its growth. Moss and colleagues recommend using MRI to screen for meningiomas in LAM patients and if the tumors are found, they advise against the use of progesterone. The scientists also suggest that patients with meningiomas ...

Researchers identify pathogen-specific gene response in human immune cells

...o encounter infectious organismsare key players in initiating an immune response. These cells arise in the bone ...processing it for presentation to the T-cell, thus initiating a cascade of immune events that fight infection. "What weve discovered is that dendritic cell matu...

Scientists identify cells necessary for tumor angiogenesis

... there was a role for bone marrow-derived cells in initiating and maintaining a functioning tumor blood vessel. Study co-author Dr. Shahin Rafii, a vascular hematologist-oncologist at Weill Medical College of Cornell University, had shown that bone marrow-derived circulating endothelial precursor (CEP) cells ar...

University of Pittsburgh researchers define precursors to cells that control the immune response

... nodes, presenting a processed antigen to T-cells, initiating antigen-specific T-cell immunity. "Scientists have known that LC precursors existed; however, the identification of an immediate LC precursor resident in the skin remained as a missing link," said Adriana T. Larregina, M.D., Ph.D., research assistant...

In groundbreaking research, Yale and Salk Institute scientists reveal the structure of a key component that makes cells move

...of seven different proteins and is responsible for initiating the assembly of the protein actin into filaments at the front end of a moving cell. This growth of actin filaments is called polymerization and is believed to push the front of the cell forward, allowing it to move. Pollard said the classic example ...

Study of key enzyme sheds new light on programmed cell death and may lead to new drugs for reducing the severity of stroke

...tents can be absorbed by surrounding cells without initiating an attack by the bodys internal self-defense syste...imal studies combined with its established role in initiating cell death raise the possibility that DAPK inhibitors could reduce neuronal cell death during this c...

Scientists identify molecular structure of cancer-related proteins

... the channel causing slight structural changes and initiating processes that determine the fate of the cells, including the formation of blood vessels. Our results may be used to discover and develop small molecules resembling the natural ligand, competing with the binding process and ultimately preventing the...

Pain in the gut? Don't blame stomach acid

... low level of acidity in the stomach is the factor initiating all these events." "The bottom-line message is that a two-week course of antibiotics to treat the inflammation is essential for a successful cure," Merchant adds. "Once you get rid of the inflammation, the gastric acid levels should return to normal...

Wild jaguar photographed in Arizona

...ing from the population south of the border. We're initiating some work in the Sonora region of Mexico to see if this population will persist and perhaps repopulate parts of the southwestern United States." Although never plentiful in the southwestern United States, jaguars did inhabit the area before being lar...

Transplanted stem cells restore function in stroke

...s that need to be conducted before we can consider initiating any clinical trial. "The next steps in this research will be to determine how long after a stroke stem cell transplant therapy will be effective. Can stem cells be transplanted one, two, six or 12 months after a stroke and still restore function? Ano...

Chemists explore the shape of the key that signals cell division in cancer cells

...es in order to determine which form is critical to initiating cell division in cancer cells. The ultimate goal is to be able to design drugs to stop the cancer cell cycle. The research will be presented at the 223rd national meeting of the American Chemical Society, April 7-11 in Orlando. Etzkorn explains, "We...

Built-in 'failsafe' device blocks abnormal growth of new blood vessels

...fits into the Fas receptor like a key in a lock -- initiating a molecular cascade in the cell that resulted in cell death. These results indicate that the angiogenesis-inhibiting activity of TSP1 and PEDF was dependent on the dual induction of Fas and FasL as well as on the resulting apoptosis. It has b...

Three-D images shed light on first steps of RNA synthesis

The first three-dimensional images of the initiating form of the molecular machinery in bacteria that "...hesize that the linker participates in binding the initiating nucleotide, and once the RNA polymerase begins synthesizing RNA, the sigma subunit is no longer need...

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