Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
...copene and vitamin E or a placebo. The researchers injected human tumour cells into the prostate of mice to see what effect the lycopene and vitamin supplements would have on the tumour growth and PSA (prostate specific antigen)[2] and to compare any effects against the placebo. Dr. Limpens, who is from the D...Chemical derived from vitamin-E shows early promise as cancer drug
...r cancer lesions. The equipment could pinpoint the injected cancer cells in the animals because the cells had previously been genetically modified by co-author LuZhe Sun from the University of Texas Health Science Center in San Antonio to fluoresce bright green under proper exposure. Using this fluores...UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
...t rely on larger molecules are used in medications injected by needle. "By proving small molecules can be effective for targeting Nef, we've shown how researchers can expand the fight against AIDS," said Weiss. The researchers reported their findings last week in the online edition of the Proceedings of the ...New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
...B, only in cancer cells. The different cells were injected into mice and all were able to establish metastati...ty to activate NF-kB. After a week, all mice were injected with bacterial lipopolysaccchide (LPS), which induced inflammation. A post-mortum inspection of the...New way to protect brain from stroke damage
...land, Oregon). What's more, the team reports, rats injected with agents known to block ASICs--including the ve...e effect of ASIC blockers in an ischemic rat. Rats injected with PcTX, which is known to specifically block ASIC1a, showed a 60 percent reduction in the area of...JCI table of contents September 15, 2004
...: Rescue of retinal degeneration by intravitreally injected adult bone marrowderived lineage-negative hematopoietic stem cells AUTHOR CONTACT: Martin Friedlander The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA Phone: 858-784-9138; Fax: 858-784-9135; E-mail: friedlan@scri...Common cold virus can cause polio in mice when injected into muscles
...oliovirus can cause polio in mice. The researchers injected a cold virus called Coxsackievirus A21 into mice t...the poliovirus receptor. Still, when the mice were injected with Coxsackievirus, it initiated infection through the ICAM-1 receptor, and caused symptoms of poli...Optimizing protein's 'death domain' halts leukemia in laboratory study
...emia cells that gave off a glow when the mice were injected with a light-emitting substance, luciferin. After they administered the reinforced BH3 alpha helices, scientists noted that the glowing regions representing the leukemia cells retreated as the cells died, and the treated mice survived longer than tho...New imaging technology at Joslin shown to detect early signs of type 1 diabetes
...which are very easily detected by MRI. After being injected intravenously, CMFN travels throughout the body, including through the tiny blood vessels of the pancreas. If these vessels have started to become permeable as a result of islet inflammation, more CMFN tends to leak out and collect in the surroundin......de inhibitor. Additionally, when skin tumors were injected with this Stat3 functional inhibitor, tumor growth itself was impaired. This study provides the first evidence that Stat3 is required for the initiation of one form of skin cancer, and that it both mediates and maintains cellular growth through exp...JCI table of contents: 1 September, 2004
...de inhibitor. Additionally, when skin tumors were injected with this Stat3 functional inhibitor, tumor growth itself was impaired. This study provides the first evidence that Stat3 is required for the initiation of one form of skin cancer, and that it both mediates and maintains cellular growth through expa...Advances in tumor angiogenesis Dendritic cells co-opted to the dark side
...umor and thus contribute to angiogenesis. The team injected an antibody to CCR6 with an attached toxin that inactivates ribosomes. The toxin is internalized only by cells expressing CCR6, ultimately resulting in cell death. Selective killing of CCR6-expressing cells led tumors to shrink. "This has opened a d...Unicellular organisms contribute more nitrogen to ocean that reported earlier
...rient for the growth of many organisms were being injected into the phytoplankton and other organic materials in every square meter of the ocean surface. "To our surprise, these unicellular nitrogen-fixers are broadly distributed spatially and vertically distributed at least down to 100 meters, and they're f...Nevada researcher re-ignites mammal reproduction debate
...lucose in selected populations of wild mammals. An injected steroid can block glucose circulation, and potentially increase the number of female offspring, while in the long term the same result may be accomplished through diet. Such a study would be able to show whether mammal populations in different regio...Sweet success in targeting sugar molecules to cells in living animals
..., they had only applied it to cultured cells. They injected the azido sugar into mice and used the Staudinger ligation to attach a phosphine molecule that carried a distinctive tag that would enable the scientists to detect whether attachment to the cell surface had occurred. The researchers found that the az...Embryonic stem cell therapy shows steady benefits in rebuilding infarcted heart
...t had been induced with myocardial infarction were injected directly into the damaged heart area either with the embryonic stem cells or were subject to a control or "sham" protocol. Three weeks after therapy, the cardiac contractile function of both groups was tested by echocardiography. Not only was the ste...When is a mouse like a test tube?
...duate students Jennifer Prescher and Danielle Dube injected the mice with an azide-mannose compound for seven ...hen repeated the experiment, but on the eighth day injected each mouse with a phosphine attached to a fluorescent molecule called FLAG. After only 90 minutes, t...The first engineering of cell surfaces in living animals
...em on their surfaces. With mice, Bertozzi's group injected the azide-containing precursor directly into the a...ies, or many other methods. These markers could be injected into organs to seek out cells with certain glycosylation patterns" -- patterns of cell-surface sugar...Progress in breast cancer progression
...s blocked the NF-kB pathway in nude mice that were injected with breast cancer cells. Under these conditions...e unable become metastatic, unlike those that were injected in nude mice where the NF-kB pathway was not blocked. Taken together, these data provide evidence fo......s blocked the NF-kB pathway in nude mice that were injected with breast cancer cells. Under these conditions,...e unable become metastatic, unlike those that were injected in nude mice where the NF-kB pathway was not blocked. Taken together, these data provide evidence fo...