New way to protect brain from stroke damage
...hers have uncovered a new culprit behind the brain injury suffered by stroke victims. Their new study, publi...up of cellular components, is essential for stroke injury as it sets off a cascade of events toxic to cells, said neurophysiologist and lead author of the stu...Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
...earchers said, "growing evidence shows that tissue injury involves the synergism of a number of mediators." They suggest that "MFAIDs control the production of a host of inflammatory mediators and thus introduce a novel therapeutic approach and drug prototype for treatment of IBD."...Long-term effects of carbon monoxide poisoning are an autoimmune reaction
...O) poisoning. CO poisoning is the leading cause of injury and death by poisoning worldwide, with about 40,000 people treated in the U.S. annually. Brain damage occurs days to weeks later in half of the patients with a serious case of CO poisoning. The physiological causes of this delayed decline were not ...Integrative biology of exercise APS Intersociety meeting October 6-9, 2004 in Austin
...ve Biology of Exercise meeting Exercise-induced injury and repair of skeletal muscle: cellular and molecular mechanisms. Chair Dan Garry and Mike Lindinger. Genetic engineering and muscle performance. Chair Joe Metzger. Basic mechanisms contributing to physical inactivity-induced disorders. Chair Fr...Virus known for its photo ops makes its movie screen debut
...ble for delivering healthy DNA to cells damaged by injury or cancer," said Leiman, a postdoctoral researcher in Rossmann's lab. "T4's baseplate proteins could be altered so it could infect human cells instead of E. coli. This study could bring us one step closer to using it as a gene therapy vehicle." Gene ...Forgetting, reminding, and remembering: The retrieval of lost spatial memory
...ms of memory loss are caused by some type of brain injury -- particularly to the hippocampus. Amnesia can arise from brain damage that interferes with memory storage, retrieval, or consolidation. What ultimately causes amnesia -- a failure to store memories or a failure to retrieve them -- is not clear. A...JCI table of contents, 16 August, 2004
...s postischemic cardiac dysfunction, apoptosis, and injury AUTHOR CONTACT: Lawrence H. Young Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA Phone: (203) 785-4102; Fax: (203) 785-7567; E-mail: lawrence.young@yale.edu View the PDF of this article at: https://www.the-jci.or...Stem cell research targets cerebral palsy
...summoned to the site of an injury, such as a brain injury that occurs in cerebral palsy. More recently, rese...t chemokines also seem to attract stem cells to an injury site. However, at least in an animal model of cerebral palsy, the healing chemicals are present for ...Newcastle scientists get UK's first stem cell license
...disease, nerve cells to allow patients with spinal injury to walk again or nerve cells to overcome the misery of Alzheimer's disease. Professor Trevor Page, Pro-Vice-Chancellor for external relations and research at Newcastle University, said: "Stem cell research is one of the most exciting and promi...New discovery may help transplants survive
...ed by a full-blown immune response to the original injury or disease), rejection rates go well over 50 percent, regardless of the therapy employed. "We are trying to understand what is happening at the molecular level so that we can arrest this process," says Dana, who has devoted much of his research to fi...JCI table of contents, 2 August, 2004
...rrow cells showed greatly exacerbated the vascular injury compared to mice transplanted with bone marrow cel... same symptoms, but all cases do have inflammatory injury to the bile ducts. Jorge Bezerra and colleagues, from Cincinnati Children's Hospital Medical Center,...'Smart gene therapy' protects against damage from heart attack
...al muscle and liver exhibited a similar decline in injury following the gene therapy treatment. In addition, one month later the untreated animals exhibited severe thinning of the heart wall and reduced heart function compared to those that received the gene therapy. After four months, the untreated rats st...... we can help them refine their movements and avoid injury to the body," McNitt-Gray said. "This goes for dental technicians, athletes, children who play sports and people who are trying to recover from crippling injuries, such as damage to the spinal cord or losing a limb."...Good bacteria trigger proteins to protect the gut
...the human gut may actually be helping to stave off injury to the lining of the intestines. According to the ...nse to commensal bacteria, they would show reduced injury from DSS. We had no idea that these receptors might be involved in protecting these tissues from dam...Warren Pharmaceuticals publishes results of preclinical evaluation
...veness of its compounds in a variety of neurologic injury and disease models. Working in collaboration with... in a wide variety of animal models of disease and injury arises because EPO is an endogenous mediator of tissue protection. By separating the bone marrow act...JCI table of contents, 1 July 2004
... kinase Cdelta as a mediator of stroke-reperfusion injury AUTHOR CONTACT: Robert O. Messing Ernest Gallo Clinic and Research Center and University of California San Francisco, Emeryville, California, USA. Phone: 510-985-3950; Fax: 510-985-3101; Email: romes@itsa.ucsf.edu View the PDF of this article at: ...UNC scientists discover molecular pathway leading to nerve growth and regeneration
... spinal cord, where disruption of connections from injury leads to paralysis. "The results of this study allow us to know more about how to promote axon growth and regeneration in the spinal cord," said Dr. Fengquan Zhou, a postdoctoral fellow of the Spinal Cord Research Foundation who works in Snider's lab...Yale researchers receive $4.5 million grant to study spinal cord repair
... focused on restoration of function in spinal cord injury (SCI) and multiple sclerosis (MS). The renewed five-year grant to the Center of Excellence on Restoration of Function (CERF) in SCI and MS at the West Haven Veterans Affairs Medical Center will fund biomedical research to benefit people with nerve ...Study sheds new light on genetic risk for Parkinson's disease
...th poor clinical outcome in people with acute head injury and stroke," Huang said. "In the brain, apolipoprotein E-4 may be involved in neuron repair and in the removal of dead cells, so if you have APOE-4, you may be at higher risk of Alzheimer's disease or poor recovery from stroke and brain injury." ...Lupus Research Institute awards $3 million in novel research grants to further new science in lupus
...f two different patterns of lupus renal glomerular injury and inflammation recently identified in work by Dr. Karin Peterson and colleagues. One patient subset had a milder form of proliferative nephritis with interferon-induced genes suggesting the entrance of activated NK cells. A contrasting subset wit...