U. of Colorado professor pioneering tissue engineering from knees to hearts to brains
... said. Her group also has developed techniques to insert drugs, including growth factors, which are released into the body as the scaffolds disintegrate....Microbial biofilm yields community genomes, metabolic clues
...xtracting DNA directly from the sample and a"small insert library." Once the sequences of short pieces of DNA were obtained, computer processing linked them to generate large genomicfragments that could be assigned to specific organismswithin the community. The researchers reconstructed nearly complete gen...Death-defying approach devised by Penn scientists to prevent cell apoptosis
...teins." After using gene-transfer technology to insert extra MRSA into cells, the researchers noticed that the enzyme-packed cells were now protected from the damaging effects of ROS. "Not only were cells protected by an overproduction of MRSA, but our tests showed that the adverse oxidation process was ...Mount Sinai School of Medicine conducting clinical trials with gene therapy for colorectal cancer
...l of Medicine. "We use gene transfer technology to insert a gene into the cancer cells that makes them visible to the body's natural immune defenses." The method of tumor immunization which Mount Sinai researchers developed involves transferring a gene that codes for Interleukin-12 (IL12) into cancer cel...Scientists at Scripps Research describe new strategy for the synthesis of glycoproteins
...yoglobin. The E. coli was evolved so that it would insert a glycosylated amino acid into the sequence of the myoglobins as they were being produced. The Tough Task of Making Glycoproteins Glycoproteins are basically proteins that have been modified so that one or more carbohydrates (sugars) a......he treatment consists of an adenovirus designed to insert a gene called p53. This gene codes for a protein that triggers cell suicide when cells start to run amok, preventing them becoming cancerous. Many tumours arise after the mutation or inactivation of p53, and in cancers of this type restoring the pro...Salk news: Gene chips and crop yield
... to take a gene for flowering from Arabidopsis and insert it into rice or poplar, and have that gene function." "We eventually want to be able to understand the function of all the proteins within an organism," said Theologis. "If you know the correct gene structure, you can clone DNA to express and study p...Gene-expression atlas will provide new direction for brain and spinal-cord studies
Using a technique to insert fluorescently labeled genes into live mice, researchers have created a new atlas that will quite literally light the way for neuroscientists to explore the maze of connections between cells in the central nervous system (CNS). The researchers who de...Study reveals patterns of gene activity in the mouse nervous system
...t substance wherever the gene is active. They then insert these bacterial artificial chromosomes (BACs) into mouse egg cells. Mapping gene activity at several points as the egg cells develop into young mice reveals which cells express that gene and how they interact with other cells in the brain. The succ...Re-engineered blood vessels show promise for bypass surgery, grafts, UMHS researchers find
...move all living cells from the rest of the tissue, insert vascular cells from the new host and then reimplant the graft. Using the host's own cells increases the likelihood of success by reducing the chance of rejection. "Small blood vessels are needed all the time for grafts to use in heart bypass surgery,...Healthy neighbors rescue degenerating motor neurons
... their findings suggest that it may be possible to insert healthy astrocytes into ALS patients to reduce or prevent motor-neuron degeneration. Motor neurons control muscle action, and they are progressively weakened in ALS, leading to paralysis and death. The collaborating teams of researchers, which includ...New pollutant cleanup technique puzzles, pleases chemists
...peculated that scientists might someday be able to insert a similar system in drinking water down a well, for example and power the removal of organohalides with sunlight....Geneticists show ripple effects of gene mutations
...ons, randomly into the genome. "If the transposons insert in a regulatory region of a gene, or inside a gene, they disrupt the function of the gene," Anholt said. Anholt's lab studied olfactory behavior because it can be readily measured and is essential for survival. The investigators isolated a series of ...Scientists at TSRI create new strain of yeast with 21-amino acid genetic code
... powerful tool," says Schultz. "We've been able to insert a huge number of amino acids that have a variety o...e scientists would have a way to site-specifically insert the unusual amino acid into any protein they wanted. They needed to find a functionally "orthogona...New 'knockout' map helps study gene functions in model plant
...scientists use a bacterium called Agrobacterium to insert a code that tells a specific gene to turn off. According to Ecker, this process of T-DNA integration has been carried out for well over 25 years, but this study provides a new perspective on using the technique to analyze gene function. Some genes...Purdue developing less costly model for studying human disease
...mbryos. Also surgery must be performed in order to insert mice embryos back into the mother, while fish embryos are grown in a Petri dish. Additionally it costs much more to house, feed and care for the mice. Collodi, who also is a member of the Program of Comparative Medicine, a collaboration of the Purdue...Genetically modified E. coli produce plant product used in foods and cosmetics, Science study says
...m. "We chose to start with E. coli because you can insert all the genes at once. Tomatoes will be more compl...cancer. The next step, according to Camara, is to insert the genes that produce this pigment into tomatoes, or other fruit that produce large amounts of lyco...Purdue genetic discovery may aid plants and human medicine
...mental plants from cuttings. If, instead, we could insert a program into the plant to activate or inactivate auxin transport at a particular time and in a particular part of the plant then the plant would automatically become bushier or produce more flowers." Further research on auxin transport will investi...NHGRI study may help scientists develop safer methods for gene therapy
...d mouse virus used in gene therapy trials tends to insert itself at the beginning of genes in the target cel...ove the design of gene therapy techniques that can insert genes in less risky areas of the genome," said NHGRI Scientific Director Eric D. Green, M.D., Ph.D.,...Yeast, wormwood & bacterial genes combine in microbial factory to make antimalarial drug
...d. Keasling noted, however, that it is feasible to insert another chemical step into the bacteria to produce a compound, artemisinic acid, that is even closer to artemisinin. And one possibility is to let the bacteria grow and evolve in a petri dish and see if they can produce derivatives of artemisinin tha...