Molecule awakens and maintains neural connections
... it unable to interact with Dasm1's usual partners inside the cell. This treatment impaired dendrite growth, "which gives us hints that there is a signaling pathway within the cell activated by Dasm1 that we need to explore," she said. The next step, the researchers say, is to knock out the Dasm1 gene in m...Common cold virus can cause polio in mice when injected into muscles
...th Coxsackievirus facilitated its unusual behavior inside the body, the study showed. The mice were injected with Coxsackievirus into their calf muscles, an unusual route of entry. Following the injection, the mice began to display symptoms of polio, including an abnormal gait, dropfoot, and lower hind limb...Bone marrow cells routinely help with wound healing
... bone marrow of the transplanted mice glowed green inside the bodies of the mice, allowing researchers to track the bone marrow cells throughout the body. Researchers found green cells throughout the body, but observed that the highest concentration of bone marrow cells was in normal skin. That was a surpr...Battle between bubbles might have started evolution
...aid. "As the RNA exerts an osmotic pressure on the inside of these little membrane vesicles, this internal p...ucrose solution created a greater osmotic pressure inside the vesicles than the solvent alone. The membranes of the simple vesicles were not as sophisticated ...Diabodies act as guided missiles targeted to mammary tumor growth
...o the cells, the radioactive diabody gained access inside tumors to induce cell death and restrict tumor gro...," Adams said. "Once the beta-emitter is delivered inside the mammary tumor cells, the radiation causes intracellular damage that probably triggers p53 driven...Images reveal how rotavirus - leading cause of diarrhea - enters cells
...rtions the genes and the replication machinery -- inside the cell." From the outer layer project 60 "spikes," each consisting of a cluster of VP4 molecules. Dormitzer and colleagues trimmed the VP4 protein down to two rocklike sub-components that make up the spike's "head" and "body." They crystallized...Trojan Horses, xenon imaging and remote controlled genes
...he major obstacles to research is actually getting inside of cells and tissue to see what is going on as it ...in figuring out how proteins interact in real time inside living organisms as well as how diseases, especially cancer, progress through the body." Xenon-E...JGI announces community sequencing program portfolio
...acter phosphatis stores huge amounts of phosphorus inside its cell. Engineers have exploited this capability to remove excess phosphorus--from fertilizers and detergents--from wastewater. Too much phosphorous can over-stimulate microbial growth resulting in eutrophication, where oxygen in the water is depl...First clinical study of new pediatric croup vaccine shows safety, tolerability in adults
...ther than antibodies, destroy virus-infected cells inside the body. The vaccine consists of Sendai virus (SeV), a mouse virus that is similar enough to hPIV-1 to act as a vaccine, but different enough to have never been associated with a human disease, according to Karen Slobod, M.D., associate member of t...Gold quantum dots have applications in biological labeling, nanoscale optics
... across cell membranes, seek out specific proteins inside a cell and label those proteins," explained Dickson. "We are basically developing the tools for in-vivo, single-molecule sensitivity and labeling in living systems in the presence of very high backgrounds. We expect to produce a new set of probes t...Muscles are smarter than you think
... This enabled the researchers to change conditions inside the muscle cells and study the effects of acidity ...surface in response to nerve signals, to move deep inside and excite the whole of the fibre. 'Chloride ions play an important role in muscle by dampening the ...Researchers report new gene test for isolated cleft lip and palate
...omosome. They identified a total of 36 SNPs, both inside and outside the gene, and nine of these variations seemed to be associated with clefting. "These individual variations, or SNPs can be assembled into a haplotype," said Mary Marazita, Ph.D., a statistician at the University of Pittsburgh and a major...Newly discovered protein may be key to muscular dystrophy
...entire muscle cell membrane, linking the framework inside the cell to the region outside of the cell. The complex is found in C. elegans, in mice and in humans. In each species, defects in the complex can cause muscle degeneration, but the exact role of the complex in disease has not been clear. In a ......Rora protein plays a role in the circadian rhythms inside a living creature. They observed a mutant murine model that has a defective Rora gene. This murine model is called "staggerer" because its genetic defect causes a characteristic loss of coordination. As it turns out, the staggerer model with a d...Scientists visualise cellular handmaiden that restores shape to proteins
... with water - a property known as hydrophobicity - inside their structure. Denatured proteins with their mis...ein structure they identified 28 separate proteins inside the cage. "We'd like to be the first to really know what happens, when the protein is enclosed and c...Stem cell research targets cerebral palsy
... virus' ability to infect a cell to get chemokines inside stem cells before they are injected. Although stem cells are immature cells coveted for their potential to become many different types of cells, donated stem cells may trigger an immune response, much like a transplanted organ. So Dr. Carroll also wi...Last of known genes identified in complex obesity syndrome
...ascades" that pass along messages and instructions inside cells -- such as to open or close the cell's entry points or to trigger relocation of "freight" within the cell. "That this type of molecule could cause BBS is particularly intriguing," says Katsanis. In additional experiments using the worm C. elega...Gene changes linked to increased eye pressure may have implications for glaucoma therapy
...d fluid builds up within the eye, causing pressure inside the eye to rise. When this happens, the optic nerve in the back of the eye can become squeezed. As this is the area that carries the visual signals from eye to brain, vision loss can occur, Borrs said. In earlier studies, Borrs and her research ...August 12, 2004 A look inside a wristwatch reveals that timekeeping is a complex affair, involving the coordination of mechanical parts providing the impulses and feedback needed to achieve precisely recurring movement. Biological clocks are equally complex, regulated by a networ...Excess levels of nitrogen, phosphorus linked to deformed frogs
...The adult parasite lives in birds, laying its eggs inside the bird; the eggs then get excreted as waste in a...ut a ramshorn snail and invades the snail, staying inside for up to 20 days when it sheds out and embeds itself in a tadpole. Inside the tadpole, the ...