A Drug Pump On A Computer Chip
...lucose levels and pumping just the right amount of insulin into the bloodstream. "Ideally, an insulin delivery pump would sense the patients blood glucose level and change the dose of insulin accordingl...Altered Genes, Altered Metabolism--Longer Life?
... may lead to testable ideasfor the way glucose and insulin sensitivity affect human longevity. Leadresearche...same familyof proteins as the receptor which binds insulin in humans; it functions as aswitchboard for signals coming into the cell which tell the cell how muc...Insulin Resistance Is A Risk Factor For Atherosclerosis In Whites And Hispanics
...researchers foundthat whites and Hispanics who are insulin resistant are at ahigher risk of developing athero...n Winston-Salem. Howard and others studied insulin resistance as part of a broad-basedInsulin Resistance Atherosclerosis Study. Preliminary findings in...E. Coli Genome Reported: Milestone Of Modern Biology Emerges From Wisconsin Lab
...y and is used as a living factory to produce human insulin and other medicines. The most important result of the work reported today is the sequenceitself, said Blattner. In January, the data were made freely available throughon-line databases such as GenBank to scientists worldwide. The E. coli genome is a ...Scientists Use IGF-I To Grow New Membranes Around Neurons
... to Cheng. Named for its structural similarity to insulin and its ability to simulate insulin's glucose-lowering properties, IGF-I is produced in the liver and is present in blood serum. During embryological development, IGF-I is found in high concentrations near tiny "bud cells" called Schwann cells whic...Regulator Of Fat Thermostat Found
...iabetics withinsulin to increase their circulating insulin levels, their blood glucoseconcentrations come dow...r a four-daytreatment period for concentrations of insulin and other hormones as well asleptin. By the third day of dexamethasone treatment, obese patients' le...Cellular 'Short Circuit' Causes Insulin Resistance
... provided a new insight intothe molecular basis of insulin resistance, a condition that can leadto diabetes. In insulin resistance, cells no longer respond toordinary levels of insulin. The scientists discovered that thi...Genetics Of Obesity And Of The Response To Chronic Overfeeding
...air resemblance for the changes in fastinginsulin, insulin response to a glucose load, plasma lipids and lipo...ding changes inbody composition, fat distribution, insulin and plasma lipoprotein levels wasalso quite apparent. These results strongly suggest that undefined...Insights Into The Proteasome - A Fascinating Macromolecular Machine For Protein Degradation
...ized by electron microscopy with a gold labeled insulin b -chain caught in transit; the bulky gold label prevents the insulin chain from passing the constriction. The enzymatic mechanism of the proteasome has been...Genetic Make-Up May Determine Response To Cholesterol-Lowering Drugs
...rotein lipase gene is tied toelevated cholesterol, insulin resistance, and severity of coronary arterydisease. Four to five years after entry into the clinical trial, researchers usedangiography, an X-ray, to determine whether new blockages had developed in thegrafts. Higher doses resulted in fewer...Rockefeller University Researchers Hunt For Type 2 Diabetes Susceptibility Genes
...possible. Type 2 diabetes is caused by ineffective insulin secretion or improper insulinaction on target tissues such as muscle, leading to impaired glucose uptake fromthe blood and increased levels of blood glucose. Type 2 diabetes is the mostcommon form of diabetes, accounting for 90 to 95 percent of cases...Antioxidants May Reduce Harmful Complications Of Diabetes
... adult-onset diabetes. In this form of thedisease, insulin produced in the body is unable to trigger the lowe...as, which increase the sensitivity of receptors to insulin throughoutthe body. Half the patients exhibited microalbuminuria, the excretion of tinyamounts of p...Biggest Acoustics Meeting Ever
...dwaves in place of needles to inject drugs such as insulin and interferon directly through the skin (3aBV3).Using this technique, the Ekos Corporation in Bothell, Washington (contact Joe Eichinger, 425-482-1108),is developing an acoustically based insulin-delivery system for people with diabetes. In another ...... implantable devices, such as nervestimulators and insulin pumps, Woody expects a steady demand for testingservices....Space Grown Insulin Crystals Provide New Data On Diabetes
Diabetic patients may someday reduce their insulin injections and leadmore normal lives because of ne...ough innovative spaceresearch in which the largest insulin crystals ever studied were grown on theSpace Shuttle. Results from a 1994 insulin crystal gr...Obesity Gene: Possible Link To Heart Disease Risk
...ciate leptin elevations in the blood withso-called insulin resistance syndrome. The syndrome -- characterize...h-density lipoprotein cholesteroland elevations in insulin -- sets the stage for heart disease. Insulin is ahormone that helps the body use glucose, its main ...Feature: Biomaterials Are Transforming Medicine
...rmones and methods toprovide a constant release of insulin for diabetics. Fortune magazine citedestimates th...h-like device could, for example, releasea dose of insulin just before a diabetic's meal. The magnetic field wouldrelease the drug by squeezing drug-containin...NASA Research Helps Map Protein Structures -- Key In The Development Of New Disease-Fighting Drugs
...cal testing thisyear. Detailed pictures of insulin proteins -- mapped from space-growncrystals -- wil...ld greatly improvethe quality of life of people on insulin therapy by reducing the number ofinjections they require. It also would reduce the cost of treatment...Australian Scientists In World-First Cell Discovery
...ing since the late 1960s when the 3D structure of insulin was determined. "The IGF, insulin and EGF receptors are all in the same family and their structures are expected to be 90 per cent si...UCSF Finding Offers Insight Into Way Genes Regulate Aging And Life Span
...ponse they have on the molecular level is adrop in insulin levels. The equivalent of the daf-2 gene in humans produces thecell receptor for insulin and insulin-like growth factor (IGF), which plays arole in regulating food metabolism. And, just as ...