Arterial wound repair in DDR1 knockout mice
...gens and other ECM components, which they bind and interact with in various ways. Considerable effort has centered on the adhesive receptors expressed during neointima formation, and Hou et al. show here that a novel collagen receptor, unrelated structurally or functionally to the better-studied integrin fami...From dolphins to the Giant Panda - chemistry at SeaWorld and the San Diego Zoo
...archers have little information on how the animals interact outside captivity. Hagey's research shows that the Giant Panda communicates using a language of scents and scent marks. Males exude long-lasting scents to demonstrate their individuality and advertise their control of territory; females radiate short...Decorin as a conduit for Lyme disease bacteria
...t of the disease. Borrelia burgdorferi spirochetes interact with host ECM components through multiple adhesive receptors, including two surface proteins that bind specifically to decorin, a proteoglycan associated with interstitial collagen in the skin and cartilage. Decorin-deficient mice show only relativel...Swarthmore chemist wins national award for research with students
...ological agents," he said, including an ability to interact with DNA, the body's genetic code. Ultimately, Pasternack and his student researchers discovered that porphyrins interacting with DNA show a unique signature in certain energy fields, a technique called spectroscopy. "We also discovered we could ...In possible boon to sickle cell victims, basic scientists find reason cells stick
...e illness might boost clogging as the two proteins interact more readily because of the damage. "The next step will be to test our results in a mouse model of sickle cell disease and evaluate potential blockers there," Brittain said. "We are still years away from taking this into the clinic, but we are one...Virginia Tech researchers explore surface solubility, polarity
... or control the solubility of a surface so it will interact with multiple molecules or a range of molecules," says chemistry professor Timothy Long. Applications, such as biomedical devices or implants that would control protein adhesion or smart surfaces that would provide more universal adhesives, are s...Researcher finds that important fungal "scaffolding" genes belong to one of four classes
...that septins in the yeast Saccharomyces cerevisiae interact with a wide variety of other proteins as well. There are major differences in the septin-associated processes of cytokinesis and deposition of new growth in budding yeast versus filamentous fungi, however, said Momany. Still, numerous similarities...Scientists sequence genome of strep throat, scarlet fever bacterium
...ID). "We need to know more about how group A strep interact with humans to cause so many different illnesses. The genetic sequence should shed light on these questions and pave the way for better treatment and prevention." "Infection with this bacterium occurs worldwide, and acute rheumatic fever is the ma......n non-enzymatic viral proteins, such as Nef, which interact with host cell proteins that HIV needs for its own growth. Strong support for developing drugs that specifically target Nef comes from the observation that people infected with HIV strains lacking the nef gene-a rarity-develop AIDS symptoms much mor...NASA satellite spots unique ocean eddy
...s, eddies are caused when northeasterly tradewinds interact with the topography of the islands. Eddies occur most frequently in the Alenuihaha Channel off the Kona coast of the Big Island of Hawaii, where they can be observed throughout the year. Eddies bring an increase in organisms that comprise the marine ......gonal transfer RNA/synthetase pair, which does not interact with other pairs existing in E. coli. Then the orthogonal synthetase was engineered so that it charges the orthogonal tRNA with an unnatural amino acid but not any natural amino acids. The orthogonal tRNA delivers the attached novel amino acid into...... an alarm system. The enzyme and the antibody both interact through another molecule called a promoter. When the antibody snags the targeted protein, it triggers the promoter that, in turn, triggers the enzyme into creating the signal. Researchers could then screen for the signal, actually a molecule of RNA, ...University of Washington professor's new book seeks to rewrite understanding of cell biology
...eing, with all their complex equipment required to interact with the outside world? Thats not an issue if the real action of cell function takes place in the cytoplasm rather than the membrane. "That would allow a membrane to develop slowly, over time," Pollack said. Pollack said that many of the ...Immune system helps prevent tumors after all
...olved in the prevention of tumors and that the two interact with one another to protect individuals from cancer development," says Schreiber. "Thats the good news." Theres also bad news, however. When MCA-induced tumors from normal mice were transplanted into healthy normal mice, they continued growing. But ...DNA gene chips and novel software used to describe kidney development
...x (ECM) genes, fibrous proteins outside cells that interact with each other and play a key role in determining the shape and activities of the cell. In newborn rats, the researchers witnessed a number of retrotransposon RNA genes, which are retroviruses that long ago inserted themselves in DNA and were then...Dartmouth researcher goes to Cape Cod to study cell division
...for healthy cell division, and what other proteins interact with p62 during cell division. The unique research facilities at MBL, which include trained divers to collect the clams, along with large volumes of aerated, filtered and chilled sea water with the proper amounts of plankton and other microorganisms...Proteins in African HIV strains interact differently with drugs
...and we don't know how those mutations are going to interact with the naturally occurring polymorphisms already present in those subtypes," says Freire....... rein-troducedthem into mice. The modified DCs can interact with collagen-specific T cells and drive them toward theTh2 phenotype, which is associated with tolerance to the corresponding antigens. Here again, tissue targeting is cru-cial,since the DCs must reach the spleen if they are to have their desired ef...Researchers find first gene that increases risk of Crohn's disease
...d mutations. If we can figure out how these genes interact with each other and the environment," she added, "...ble to define which strains of intestinal bacteria interact with Nod2 to increase or decrease intestinal inflammation." Several patent applications involving t...... “That alteration makes the modified protein interact with another protein -- in this particular case with SMN -- with much higher avidity,” Dreyfuss said. The alteration of the arginines quite likely changes the shape of the protein’s surface, making it fit SMN more snugly, he explained. ...