Tag: "interferon" at biology news

Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases

...umor with generalized antitumor chemicals, such as interferon and tumor necrosis factor, as well as activated T-...d cytokines -- including tumor necrosis factor and interferon -- that mobilize generalized killing machines such as macrophages, neutrophils and natural killer ce...

Researchers identify protein promoting vascular tumor growth

...se current therapies including steroids and alpha interferon have a number of high-risk side effects. Steroids...d cause weight gain and irritability. Use of alpha interferon as a medication in children can cause irreversible neurologic damage. Surgical removal is too danger...

Other highlights in the September 1 JNCI

... may be able to help determine the optimal dose of interferon alfa for patients undergoing immunotherapy. Contact: Michelle Gailiun, Ohio State University, 614-293-3737, gailiun-1@medctr.osu.edu Scientists Outline Best Methods for Determining Health Benefits of Diet and Exercise Changes in patterns ...

Researchers develop better understanding of immune response to viral infection

...ally depleted, resulting in a dramatic decrease in interferon levels, other cell types compensated for this deficiency by secreting cytokines that ensured an efficient activation of NK cells and substantial control of MCMV infection. "In this study, we demonstrate that TLR9 recognizes MCMV in IPC and DC and tha...

Patients' cells from tumors, the immune system merged for customized cancer therapy

...ubled the percentage of CD4+ T cells that produced interferon gamma, a cytokine integral to the immune response....d the percentage of CD8+ T cells that produced the interferon in response to exposure to the tumor. "The increase of these interferon-producing T cells indicated...

Susceptibility of mice to mousepox offers promise of smallpox protection

...ine antivirals and cytokines such as such as gamma interferon to increase the efficacy of the treatment of poxvi...immune system cells to produce an immune response: interferon gamma (IFN-), interleukin-2 (IL-2), and tumor necrosis factor (TNF). Collectively, this is known as ...

Small trial shows daclizumab add-on therapy improves MS outcome

...ith multiple sclerosis (MS) who did not respond to interferon alone found that adding the human antibody daclizu...essive 3 MS. Each patient was treated with beta interferon - a naturally occurring antiviral protein commonly used to treat MS. Patients also received 7 treat...

Jay Levy honored with 2004 Abbott Laboratories Award in Clinical and Diagnostic Immunology

...wn that the interaction of CD8+ cells with PDCs or interferon restores antiviral responses. After graduating with high honors from Wesleyan University, Levy received Fulbright and French Government fellowships to conduct research at the Universit de Paris in France. He earned his medical degree from the Col...

Viral immunosuppression: Not just a game of hide and go seek

...tivation of DCs. Ironically, the release of type I interferon in response to LCMV infection, which normally cont...niversity discusses the paradoxical role of type 1 interferon in the immune suppression following LCMV infection and the novel way in which this virus not only el...

JCI table of contents, March 1 2004

...tivation of DCs. Ironically, the release of type I interferon in response to LCMV infection, which normally cont...niversity discusses the paradoxical role of type 1 interferon in the immune suppression following LCMV infection and the novel way in which this virus not only el...

Anti-interferon beta antibodies in MS care: A consensus

...zing antibodies (NAbs) has a significant effect on interferon beta therapy and this issue warrants the attention...S patients take disease-modifying therapies called interferon betas, which reduce the frequency and severity of MS relapses or attacks, reduce brain lesion develo...

Structure solved by Scripps scientists shows one way that body controls gene expression

...ctor (TNF) and interferons, by marking the TNF and interferon mRNAs for destruction. With incredible specificity...omain to recognize particular sequences of TNF and interferon mRNA. By solving the structure, Wright and his colleagues revealed for the first time in atom...

Novel therapies show promise against myeloid leukemia

... tumors in the lungs of immunodeficient mice. The interferon was produced by MSC after their infection with a v...nic myeloid leukemia in blast crisis, MSC-produced interferon alpha (IFNaMSC) inhibited tumor growth in vivo and doubled the survival rates of CML bearing mice. ...

Cytokine signal shuts down hyperactive T cells

...lus of activated T cells and increasing amounts of interferon gamma, a cytokine that activates antigen-presenting cells and other parts of the immune system. These results differed from previous studies that showed IL-27 to be among the many cytokines involved in T-cell differentiation and growth. Despite its ...

UB researchers show first evidence of pharmacogenomic differences in patients' responses to MS drug

...idely used drug for treating multiple sclerosis -- interferon beta (IFN-beta-1a) -- can modulate the expression of particular genes in patients being treated for the disease. Their results show that IFN-beta-1a initiates different patterns of genetic expression in different MS patients, information that could ...

Zadaxin in triple therapy shows 61% response for hepatitis C non-responders

...owing ZADAXIN® in combination with pegylated interferon alpha and ribavirin produced a 12-week early virol...ents who had failed to respond to prior therapy of interferon in combination with ribavirin. By comparison, separate recent studies show that pegylated interfero...

Improving the body's 'homeland security' against TB

...otably James Darnell's seminal descriptions of the interferon and Jak-STAT pathways, Zanvil Cohn's pioneering experiments on macrophage immunobiology and Christian de Duve's Nobel Prize-winning research on the lysosome. Others, such as current faculty members Ralph Steinman and Charles Rice, are similarly inter...

White House awards National Medal of Science to Rockefeller University's James Darnell

...tch on a group of interferon-responsive genes when interferon contacts cells. Interferon, a cytokine used in anti-cancer and anti-viral therapy to halt or slow proliferation of cancer cells or viruses, is sometimes used in combination with chemotherapy. Darnell's lab also has shown that the persistent activati...

First company founded on UCF biotechnology formed

...is groundbreaking methods of growing drugs such as interferon in tobacco leaves. "Tobacco is the fruit fly of p...it costs about $26,000 per Hepatitis C patient for interferon therapy (of a few months' duration). However, the daily income of one-third of the world's populatio...

Scientists develop new RNAi knockdown technology

...aken a few different routes to avoid eliciting the interferon response, and while some have been successful, non...oreign RNA into a cell), which both side steps the interferon response and allows for the tissue-specific suppression of gene expression. This vector, called pDEC...

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(Date:7/28/2014)... Most cells do not divide unless there is enough ... cells and other cell types circumvent this rule. Researchers ... mechanism that overrides the cells, warning signals, enabling cancers ... supply. In the process, the researchers found that lysosomes ... cell division decisions. They also uncovered new evidence that ...
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