Hopkins researchers find potential new treatment for children with chronic hepatitis C
...ndomized controlled trial to test this new form of interferon alone, or in combination with ribavirin, an antivi...h CHC have been treated with three shots a week of interferon to increase the amount of the naturally occurring infection fighter. Peginterferon alfa-2a is a new,...New drugs restore immune response blocked by hepatitis C virus in human cells
...tors will become an important addition to existing interferon treatments for hepatitis C and that they will have equal if not greater impact on the treatment of this important form of liver disease," he said. The lead author of the study was Eileen Foy, a student in UT Southwestern's Medical Scientist Training ...Key to hepatitis virus persistence found
...pecifically inhibits a key immune system molecule, interferon regulatory factor-3 (IRF-3). IRF-3 orchestrates a range of antiviral responses. Without this master switch, antiviral responses never begin, and HCV can gain a foothold and persist in its host. Next, the scientists searched for ways to reverse the I...Interferons effective against smallpox
...no mice survived. Intranasal administration of interferon alpha and interferon gamma provides nearly full protection against respiratory vaccinia virus infection in mice, says Liu...New mouse virus may help scientists better understand cruise ship epidemics
...Mice that lack Stat1 cannot respond efficiently to interferon and lose most of their innate immune response. Mice deficient in both Rag and Stat1 have no adaptive and very limited innate immunity. Virgin and colleagues discovered that mice with Stat1 but lacking Rag survived MNV-1 infection, while those lacking...First clinical trial of intravenous rViscumin under way in Germany and France
...kines, including interleukins (IL-1b and IL-6) and interferon gamma, and is also associated with inducing anti rViscumin antibodies. So we are seeing a definite immune system response to the drug, although at this stage it is far too early to draw any conclusions about possible clinical significance or benefits...Other Highlights in the July 3 Issue of JNCI
...ed with the nitric oxide-vitamin B12 analogue plus interferon β, which increases expression of the receptor that takes vitamin B12 into cells, the tumors were eradicated. The authors suggest that the vitamin B12 analogue inhibited tumor growth by inducing apoptosis, or cell death. The findings appear in th...Collaboration advances potential therapy for autoimmune diseases
...g monoclonal, humanized and fully human - to gamma interferon to treat multiple sclerosis, rheumatoid arthritis,...ted limited clinical trials of antibodies to gamma interferon for rheumatoid arthritis and multiple sclerosis. Through this collaboration, and under its patent...Buffalo neuroimaging researchers studying multiple sclerosis from inside human brain
...f clinical trials supervised by Jacobs. The drug, interferon beta-1a (Avonex), slows progression of disability ...possibility might be a drug cocktail that includes interferon and a neuroprotective agent to target and preserve the gray matter." Bakshi's own research could po...Racial differences explored in treatment response for hepatitis C
... of combination therapy with long-acting pegylated interferon alpha-2a (PEGASYS) and ribavirin, an anti-viral me...ve improved to more than 50 percent with pegylated interferon and ribavirin combination therapy, compared to 10 to 15 percent for patients treated with interferon...New treatment for difficult-to-treat inflammatory disease
...stly affects men. Steroids, hydroxyurea and alpha interferon have all been used to treat the disease, but often unsuccessfully. Even when those treatments do work, they often cause unwanted side effects. In a letter appearing in this week's The Lancet, Gerald Gleich, M.D., and colleagues from the Mayo Clini......ncers, and multiple sclerosis. Yet many aspects of interferon biology remain a mystery including what initially...he body able to launch a massive, initial round of interferon production. Their work, reported in the current issue of the Journal of Experimental Medicine, is ch...New genetic technique delivers knockout blow to 'Asthma Virus'
...iRNA acts by a mechanism that does not involve the interferon response that is triggered by viral infections....... in Dallas have linked abnormal secretion of alpha interferon to the malfunctioning immune systems of young pati...viruses. Once that virus-fighting job is done, the interferon normally disappears, but not in lupus patients, she said. Pascual said blocking the abnormal alpha-i......se II clinical trials employing the companys omega interferon for the treatment of patients chronically infected...conference in Dallas on November 11, 2001. "Omega interferon is a natural human interferon produced by genetic engineering technologies," said BioMedicines Chief...Alcohol researchers show 'friendly' virus slows HIV cell growth
...r if the GBV stimulates cellular proteins, such as interferon or immune cytokines, that protect the cells against HIV growth." Understanding the mechanism by which GBV-C retards HIV progression holds promise for designing new treatments that will prolong life for HIV-infected patients. "It may be reasonable to...Immune system helps prevent tumors after all
...ave found evidence that both lymphocytes and gamma interferon (IFNg), a protein produced by certain lymphocytes, might play important roles in tumor prevention. So Schreiber and colleagues decided to explore further. In this current paper, they used a strain of mice that completely lacked functional lymphocyte...New light shed on vitamin A's role in the body's natural defenses
...ts natural interferon's regulatory response. Less interferon may be necessary when the active form of vitamin A...isease, the gut is the target. Modified forms of interferon are currently being used to treat various autoimmune diseases such as multiple sclerosis, arthritis,...UI researchers investigate regulation of immune system memory
...UI team has found that two molecules, perforin and interferon gamma, already known to participate in the fight a...rs elucidated the regulatory roles of perforin and interferon gamma. The mice were infected with Listeria monocytogenes, a bacterial pathogen that causes food-bor......AviGenics of Athens, Georgia, has produced a human interferon for treating cancer in its flock of birds. It clai...ival because it has already managed to pass on the interferon gene to further generations of birds. With hens producing an average of 200 eggs each per year, and ...