Martin Saunders to receive the James Flack Norris Award
...tions -- one of the three main species of reactive intermediates in organic reactions including the formation of many natural substances such as the steroids. The approach Saunders took was to create stable solutions of these normally highly reactive species, so that they could be studied by NMR. This allowed him ...Prion propagation: Avoiding the toxic oligomer
...ormation. Mounting evidence suggests these amyloid intermediates are the "toxic species" underlying amyloid diseases. It is not clear, however, whether amyloids follow a progression from monomer to oligomer to plaque. Using the yeast prion protein Sup35 to study how amyloids form, Jonathan Weissman and colleagues ...Amyloid fibers sprout one step at a time
... with the structured fibers, rather than being key intermediates in fiber formation. Such a possibility could have implications for treating amyloid diseases such as Alzheimer's and Parkinson's, he said. "Investigators are now screening for drugs that would prevent amyloid from forming, to treat these disorders,"...U of T research answers key question in biochemistry
...f the Holy Grails of biochemistry," says Kay. "The intermediates that we can study make up only one or two per cent of the population of protein molecules in solution. It's hard to study them because they are present at such low levels. This is the first time we have been able to characterize an intermediate state...Carnegie Mellon U biologists identify critical player in yeast ribosome assembly
...at direct ribosome assembly should yield even more intermediates for study, according to Woolford, whose research was supported by the National Institutes of Health and reported in the May 7 issue of Molecular Cell. In collaboration with Martin Farach-Colton at Rutgers University, Woolford is currently developing...Chemists create unusual lariat RNA, a key intermediate in biological splicing
...nd posted on its Web site "Lariat RNAs are crucial intermediates in the biological splicing of messenger RNAs," Silverman said. "The lariat RNAs synthesized by our new DNA enzymes should help provide a detailed biochemical understanding of RNA splicing." Lariat RNAs have an unusual connectivity in which a key "bra...ALife experiments show how complex functions can evolve
...hat such features must have arisen through lots of intermediates and, moreover, that these intermediate structures may once have served different functions from what we see today. The crystalline proteins that make up the lens of the eye, for example, are related to those that serve enzymatic functions unrelated ...Artificial life experiments show how complex functions can evolve
...hat such features must have arisen through lots of intermediates and, moreover, that these intermediate structures may once have served different functions from what we see today. The crystalline proteins that make up the lens of the eye, for example, are related to those that serve enzymatic functions unrelated ...Virginia Tech inventions, creations can improve lives
...l analogs" (6,476,242). The compound, analogs, and intermediates may be used to form pharmaceutical compositions having anti-neoplastic activity and may be used to treat cancer. The natural product paclitaxel is an effective antitumor drug against breast and ovarian cancer and some lung cancer; however, there is a...Richard A. Lerner and Peter G. Schultz to receive Paul Ehrlich and Ludwig Darmstaedter Prize 2003
...s a result, there are more reactive conformational intermediates that possess more energy than the molecular conformations before and after a chemical reaction. However, the fundamental difference between the reactions of enzymes and antibodies lies in the fact that enzymes-- contrary to antibodies-- preferably st...Lower insulin sensitivity found In Mexican-Americans, regardless of behavioral and metabolic factors
... all subjects to examine insulin-signaling pathway intermediates and glucose transporters in skeletal muscle. Results The researchers found that: Mexican-Americans were found to be significantly less insulin sensitive compared with their NHW counterparts. There were no significant differences between the tw...X-ray analysis of shipwreck may help conservators save waterlogged artifacts
...ated within the beams. The presence of many sulfur intermediates indicated stepwise oxidation toward a corrosive end product of sulfuric acid. In the air of the museum, iron species in the wood were catalyzing oxidation of the accumulated sulfur. Almost half of the sulfur has already been oxidized, according to th...Ohio State chemist wins national award for study of reactive intermediates
...material], absorb visible light, generate reactive intermediates which damage the nucleic acid and inactivate the pathogen, he said. As plasma protein and red cells contain no nucleic acid, these blood products are spared. When asked what first attracted him to science, Platz recalled the race to the moon. I dream...Pulmonary hypertension in newborns linked to nitric oxide production
...dies, Summar and colleagues will supply urea cycle intermediates like citrulline and arginine to at-risk infants to "see if we can block the development of pulmonary hypertension in these babies," he said. In addition to the health benefits for the infants, the cost savings could be significant. Citrulline and a...Berkeley chemical engineer wins national award for catalysis research
... techniques. They give us a set of eyes to see the intermediates and products of catalyzed reactions, as well as the structure of catalysts themselves," says Bell, a chemical engineer at the University of California, Berkeley. Catalysts are the highly skilled construction workers of chemistry, assembling one pro...Feds give $16 million to UNC-CH scientists studying waste site problems
... The former provides custom synthesis of metabolic intermediates for dosing experiments, labeled compounds for spiking standards for microanalysis, products for structural verification and specialized reagents. The latter does both routine analysis and methods development using a variety of ionization sources and ...Detroit researcher receives national award
...l steps of such reactions, analyzing which radical intermediates form and measuring how long each step takes. One reaction is orchestrated by a type of protein in the liver called cytochrome P450. This enzyme family adds oxygen to, or oxidizes, nearly everything it encounters. It breaks down drugs and fats, makes ...Distance between atoms is key to iron protein function
...iques to probe the molecular structure of peroxide intermediates in diiron proteins. While scientists have known ...," he added. Molecular structures of peroxide intermediates were identified by Penner-Hahn and former U-M post-doctoral fellow Jungwon Hwang. The biochemistry...Another small cog in the 'hub' of metabolism unraveled
...amino acids, and it is also an important source of intermediates for the production of other biochemical compounds. One of the key enzymes in this process is succinate dehydrogenase. It is embedded in the mitochondrial membrane and couples the citric acid cycle to the respiratory chain. The coupled action of these...Compounds From Fruits, Vegetables And Grains Slow The Growth Of Human Tumor Cells
...We think thatthis deprives tumor cells of chemical intermediates they need to multiply. Thetwo compounds even work on human tumor cell lines that have mutations known topromote cancer." Studies consistently have shown that people who eat a diet high in fruits,vegetables and grains have a reduced risk of many types...