Common therapy for HIV associated with cervical abnormality regression
...isk of abnormalities in the cervix called squamous intraepithelial lesions (SIL). In healthy women, the low-grade form of this type of abnormality often disappears on its own without treatment. Also, women who are HIV-positive are at an increased risk of infection with human papillomavirus (HPV), which are known to ...Other highlights in the February 18 issue of JNCI
... subsequent progression from premalignant cervical intraepithelial neoplasia (CIN) to invasive cervical cancer. Renske Steenbergen, Ph.D., of the Vrije Universiteit Medical Center in Amsterdam, and colleagues examined the role of the gene that encodes an adhesion molecule called tumor suppressor in lung cancer 1 (TS...First animal model for pancreatic cancer may lead to early detection of disease
...th pancreatic cancer. Themice developed pancreatic intraepithelial neoplasms (PanIN), a conditionthat preceded development of full-blown invasive pancreatic cancer.Interestingly, coauthors Drs. Emanuel F. Petricoin and Lance A. Liotta atthe FDA/NCI observed that the mice with PanINs had a unique group ofproteins in ...HPV testing could be future strategy for primary screening for cervical cancer
...alignant cervical cells called high-grade cervical intraepithelial neoplasia (CIN2/CIN3); however HPV testing is less specific than cytology (ie. it produces more 'false-positive' results). HPV testing as a primary screening approach is only feasible if appropriate management is given to women who are HPV-positive w...Intraepithelial neoplasia may be a leading risk factor for prostate and ovarian cancers
...o develop identification and treatment methods for intraepithelial neoplasia," said Scott Lippman, M.D., of the M.D. ...y studies have suggested that high-grade prostatic intraepithelial neoplasia (HGPIN, abnormal growth in the glands or ducts of the prostate) is a precursor to prostate...... epithelial cells, in the regulation of intestinal intraepithelial lymphocyte activity. Blumberg et al. examined whether CD1d expression could be regulated by intestinal luminal contents using colon-derived tissue culture cell lines. Alone, these cells express only low levels of CD1d, however when cultured in the pr...Telomere shortening may be early marker of cancer activity
...rom the shortening may play a causal role in human intraepithelial neoplasia (IEN) found in precancers. "Normal huma...rtening and telomere length heterogeneity in human intraepithelial neoplasia (IEN) The objective of this study was to build on research that Meeker and his team had c...Study provides direct evidence of the role of telomeres in prostate cancer development
...dy probed telomere lengths in high-grade prostatic intraepithelial neoplasia (HGPIN), the pre-invasive precursor to prostate cancer. Results showed that the telomere lengths of epithelial cells (relating to cellular tissue) within HGPIN lesions were strikingly shorter than those of adjacent normal-appearing epithel...Leading cancer research organization urges FDA to speed approval of drugs for precancers
... percent of all patients with high-grade prostatic intraepithelial neoplasia (HGPIN) and no detectable cancer develop cancer three years later, with cancer incidence growing to 80 percent in 10 years. "We need to evaluate what we now know about cancer prevention and move forward rapidly to make new investments in...Hopkins researchers test new molecular marker for prostate cancer
... precancerous lesions, called high grade prostatic intraepithelial neoplasia. "Since AMACR enzymatic activity is not found in most normal tissues, it could be an excellent candidate for the development of molecular probes for non-invasive detection of prostate cancer and as a potential drug target," says June Luo, ...Other highlights in the Jan. 16 issue of JNCI
... significance [ASCUS]) or mild (low-grade squamous intraepithelial lesions [LSIL]) abnormalities. Only about 5% of w... have a known precursor to cancer, called cervical intraepithelial neoplasia 3 (CIN3). Therefore, referring all women with ASCUS or LSIL for colposcopy (examination of...Hopkins researchers develop potential new screening test for prostate cancer
...disease. The researchers also evaluated prostatic intraepithelial neoplasia (PIN) lesions found in 28 of the 69 patients with early-stage disease. PIN lesions are thought to be early precursors of prostate cancer. High levels of GSTP1 methylation were detected in 63 of 69 (91.3 percent) early-stage cancers and in...Common genetic mutation linked to uterine cancer
...iferative (slightly abnormal), or EIN (endometrial intraepithelial neoplasia , or clearly defined precancers). Utilizing laser capture microdissection and highly sensitive immunohistochemistry, they selected cells from each group and compared PTEN function across sample lines. Loss of PTEN function was apparent in 4...Scientists identify new vaccine targets for cancer-causing strains of human papilloma virus
...e vaccine for treatment and prevention of cervical intraepithelial neoplasia (CIN), pre-cancerous lesions that develop into cervical cancer. An estimated 20 million Americans are infected with HPV, a virus that is well known for causing genital warts but also accounts for over 95 percent of cervical cancer cases. ...Sexually Active Younger Women Are At Higher Risk For Infection With Human Papillomavirus
...s types ofabnormal cells. One such type, squamous intraepithelial lesion, a potentiallypre-cancerous condition, is causedby HPV infection of cervical cells, and is usually first detected as an abnormalPap smear. The authors caution that because of the six-month interval between medicalvisits, the study results may ...