JCI Table of Contents, 15 August 2003
...thepsins, which degrade the MHC class II chaperone invariant chain to generate class IIassociated invariant chain peptides. Eva Tolosa and colleagues from Tbingen University Hospital, Germany, have now charac...Novel molecule may contribute to intestinal health
...lation of immune cells known as mucosal-associated invariant t cells (MAIT cells). MAIT cells were just recently discovered by the studys other co-senior author, Olivier Lantz, Ph.D., at the Institut Curie in Paris. The current study presents the first extensive characterization of these cells. These results h...Scientists develop 'super peptide' that kills Candida albicans
...MSH amino acid sequence (6-13), which contains the invariant core sequence His-Phe-Arg-Trp (6-9) that is important for binding to the known melanocortin receptors. A second focus was on the sequence Lys-Pro-Val (11-13) that is known to be important for antimicrobial activity. In this structure-activity stud...Researchers discover precise olfactory map
...f neurons with the same receptor converge in a few invariant glomeruli, creating a map of odor receptor inputs that is nearly identical in different individuals. But what happens to odor signals at higher levels of the nervous system to generate different odor perceptions and emotional responses? "It had been......of California at Berkeley. "We thought it would be invariant from cell to cell, since it was so fundamental to the cells in transcribing DNA," he said. "So, when we discovered the TAF family of proteins, we never anticipated that there would be cell-type-specific versions," said Tjian. "But then five years or ...