Tag: "kinase" at biology news

Drug stops blinding blood vessel growth in mice

...nk in the chain. A fewlinks downstream is protein kinase C, an enzyme that appears to be important inkeeping the chain reaction going. Platelet-derived growth factor (PDGF) isstructurally similar to VEGF and may stoke the fires of the chain reaction fromanother direction. PKC 412 may mount a th...

Gene treatment can boost heart function in rabbits, Duke researchers say

...eceptors (ßARs) and beta adrenergic receptor kinase (ßARK) --work together to regulate heart function. Receptors such as ßAR are molecularswitches that turn on cell processes when triggered by external substances suchas hormones. In reacting to a failing heart, the body releases large amo...

New components of machinery that carries genetic information from nucleus

... other of the suspected kinases. Depending on the kinase blocked, weexpected to see buildup of either IP3 or IP5, with no IP6 in any case." Sureenough, said York, the experiments indicated that the mysterious genes coded forkinases, or at least their regulators, transformed IP3 to IP4, and IP5 to IP6. ...

Protein studies reveal sophisticated control of nerve communication

... activates an enzyme called cAMP-dependent protein kinase (PKA), and hownerve cells organize specialized pools of PKA so that these pools will be readyfor instant use. As it turns out, PKA is one of the two enzymes that yotiao holds near theNMDA receptors. Whenever the anchor protein releases it, PKA stimu...

Hepatitis C's interferon resistance mechanism discovered

... This triggers the infected cell toproduce protein kinase (PKR), an enzyme that adds a chemical entity known as aphosphate group (a process called phosphorylation) to a variety of proteins,including itself. Among PKR's targets is a protein called eukaryotic initiation factor 2(eIF2 a ). Adding a phosphate...

Scientists uncover how a colon-cancer prevention drug works

...cer-cellgrowth. "We found that sulindac inhibits a kinase (an enzyme that adds phosphate ontoits target), which in turn prevents the activation of NF-kB," Gaynor said. "Thiskinase should be an excellent target not only for the development of novelanti-inflammatory agents but also for the development of agen...

Scientists identify novel component of cell-fate pathway

...at lead to cancer. The new component, casein kinase I (CKI), adds another step to thepreliminary outline of how the Wnt-signaling cascade functions. Dr. Jon Graff,assistant professor in the Center for Developmental Biology, and colleaguesdescribe CKI's integral role in the pathway in the lead article ...

Cancer gene is normally a 'carpenter' in the cell

...sphate to the c-Abl protein, the normalaction of a kinase triggering another enzyme. The scientists al...clinical trials to treatleukemia by blocking c-Abl kinase activity may also be used to treat these coloncancers." According to Pendergast, the Src and...

New molecular clues to herpes control

...tics and microbiology, note that a cellularprotein kinase called JNK (pronounced 'junk'), seems important fo...sturbed. A disturbance such as preventing aprotein kinase from activating a transcription factor may reduce HSV1's abilityto subvert the pathway. "Our studies...

Choice of sex in animal breeding? Excess of male progeny from males carrying mouse responder transgene on Y chromosome

...ir progeny, showed that it encodes a novel protein kinase likely to control sperm motility. The gene can eff...codes a mutant form of a member of a novel protein kinase gene family, Smok , expressed during spermiogenesis, the process transforming round haploid spermat...

Study may help clarify how cells grow

...the study's principal investigator, the enzyme MAP kinase (MAPK) is a key component of a signaling pathway i...appens is that in response to a growth signal, MAP kinase attaches a phosphorous molecule to CPS II, thus preventing feedback inhibition and allowing cells to...

New link uncovered in nerve cell mechanism thought to power learning and memory

...th GluR1 a constitutively active form of a protein kinase (CaMKII) known to be sufficient to elicit the synaptic strengthening that is the hallmark of LTP. To investigate the mechanistic relationship between AMPA receptors and CaMKII, Malinow and his colleagues mutated a site within GluR1 that had been show...

Cell division study aids cancer drug search

...ns identified by the researchers are cyclin E-Cdk2 kinase and group known as p300/CBP....

Aptosyn™ (exisulind) and other SAANDs target early event in cancer; AACR presentations detail novel apoptotic pathway

...nstream regulators of apoptosis: beta-catenin, Jun kinase and Erk. These downstream regulators are thought ...P in apoptosis pathways via cGMP-dependant protein kinase (PKG). "We found that Aptosyn™ activates PKG in colon cancer cells, not directly, but by bl...

Northwestern team identifies first enzyme in mammalian circadian clock

...vides the first evidence that a gene called casein kinase I epsilon is a critical component of the mammalian... circadian gene, Clock, in 1997." While casein kinase I epsilon, or CKIe, is the ninth gene to be identified with circadian rhythms in mammals, it is the ...

UCSD researchers find genetic key to puzzling congenital disease

... human disease found to be linked to the I-kappa-B kinase (IKK) signaling pathway, the master switch for the body's immune and inflammatory responses, and for programmed cell death. We have a nearly perfect mouse model of this disease," said Constantin Makris, Ph.D., principal author on the paper and a post...

Molecular mechanism for learning and memory is identified

...e and function. In the case of GAP-43, the protein kinase C (PKC) is the enzyme responsible for its phosphorylation. The researchers first studied four different types of mice and their ability to learn by putting them through a battery of tests. The tests of spatial and working memory became increasingly...

Cell Pathways scientists describe mechanism by which SAANDS compounds trigger programmed death in cancerous and precancerous cells

... cells and the induction of cGMP-dependent protein kinase G (PKG). This rise in PKG activity causes beta-cat...cGMP occurs, triggering cell death through protein kinase G. In normal cells, the cGMP pathway does not appear to be important in the regulation of apoptosis....

Science: Prion proteins may signal trouble -- literally

... enzyme called "Fyn," The Fyn enzyme is a tyrosine kinase capable of stimulating multiple intracellular events that change, for example, a cell's responsiveness to other nervous stimuli, said Odile Kellermann and her collaborator, Sophie Mouillet-Richard, lead author of the Science paper. The research ...

Scientists develop chemical switch for natural signaling molecules, opening new approach to biomedical research and drug design

...genetic techniques to carve out a small part of a kinase molecule - a constituent common to the many hund...The added molecule inhibited, but did not destroy kinase function -- just what is needed to tease apart the unique role of one kinase from all others. The...

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