Tag: "kinase" at biology news
Two routes to FAK activation and cancer cell migration
The focal adhesion kinase
(FAK) is one of the first intracellular proteins t... on the surface of responsive cells, stimulate the kinase
c-Src to phosphorylate FAK. NEP is known to cleave these neuropeptides, and Sumitomo et al. confirm...
Breast cancer susceptibility gene
...ered that after cells are exposed to UV light, the kinase
ATR phosphorylates BRCA1 at six different sites. By up-regulating or down-regulating ATR expression levels, Dr. Abraham and colleagues were able to observe that BRCA1 phosphorylation increases or decreases, respectively. Phosphorylated BRCA1 relocal...
Novel protein is both ion channel and enzyme
...sient receptor protein-phospholipase C-interacting kinase
(TRP-PLIK), is a member of a family of ion channel...nel function. There is also good evidence that the kinase
can phosphorylate other proteins in the cell." According to Clapham, the discovery of TRP-PLIK came...
Gene therapy for muscular dystrophy
...delivered under the control of the muscle creatine kinase
promoter which is muscle-specific -- there was no immune response. What we think happens is that if the virus gets into tissues that are very good at presenting foreign proteins to the immune system, then an immune response is generated to any prote...
Yale researchers find all of the gene targets for a protein
...hers overexpressed nearly all of the yeast protein kinase
and analyzed them using 17 different substrates and protein chips. Protein kinases are key regulatory molecules that control many biological processes. They discovered many novel activities of the protein kinases that were not known previously. "Our ...
ER stress in inflammatory bowel disease
...nt chaperone protein BiP and of the protective MAP kinase
pathway, which acts in both the unfolded protein response in the ER and in similar cytoplasmic pathways, as expected if the absence of Ire1b is required for homeostasis in response to increased levels of unfolded proteins in the secretory pathway. E...
Scientists find great-granddaddy of enzyme family
...trol the enzyme, Sanders says, noting that acetate kinase
comes from a methane-producing bacterium and is re...ouse gas. The structure also suggests that acetate kinase
may be the common ancestor in a "superfamily" of enzymes known as phosphotransferases, named for the...
Scientists identify process that plays key role in brain changes involved in cocaine addiction
...f a specific brain protein called cyclin-dependent kinase
5 (Cdk5). The same group of researchers previously found that Cdk5 regulates the action of dopamine, a chemical messenger in the brain associated with the cocaines pleasurable rush and with addiction to cocaine and other drugs. The Cdk5-related proce...
Nanogen reports progress in development of electronic technology for high-throughput screening of protein kinases
...rly important in signal transduction pathways, and kinase
dysfunction is thought to contribute to many forms of cancer. At Screentech 2001, Nanogen presented its progress towards developing different formats of electronic HTS technology for protein-kinase analyses. The formats involve electronic HTS plates...
University of Florida researchers identify a protein that may induce drug resistance in lung cancer cells
...researchers have linked a protein known as protein kinase
C-epsilon, or PKC-epsilon for short, to this transition. While the gene for the protein does exist naturally in small-cell lung cancer cells, it normally is inactive, so the protein is not produced. In laboratory cultures of small-cell lung cancer...
With an eye on safety, UF experts explore cellular mechanisms of gene therapy
..., Flotte said. The protein - DNA-dependent protein kinase
- is abundant in human cells. "That puts it into a relatively safe form in which the therapy can work but where it's not likely to trigger the formation of a tumor," he said. The scientists discovered the protein's role in the process by comparing ...
Northwestern receives $17 million for functional genomics research
...r, the lab used similar methods to identify casein kinase
I epsilon as the first enzyme target for circadian rhythms in mammals. Using a battery of high-throughput tests, Northwestern researchers first will screen the mice for specific behaviors, such as response to light and the timing of activity and rest...
Study reveals molecular key to tumor suppressor activity
...umor cells p53 is not working, sometimes because a kinase
gene responsible for p53 phosphorylation is mutate...o restore p53 function in tumor cells with mutated kinase
genes. We could give the compound to patients to wake up the p53 or prevent its degradation." Thus...
Scientists decipher "fail-safe" system that limits gene copying in cells
...ocking them out of commission in different ways. A kinase
causes one replication factor called Mcm to get ex...r "origin recognition complex," is de-activated by kinase
through a still-unknown process. Kinases are ubiquitous enzymes widely used in cells to regulate oth...
Integrins and signaling in psoriasis
... of these receptors. The authors focus on the MAP kinase
pathway, which mediates integrin effects on basal ...onstitutively active version of the regulatory MAP kinase
kinase MEK to maintain high MAP kinase
activity in suprabasal cells, thus promoting keratinocyte gro...
Mechanism believed found that regulates movement within cells
...ein, known as calcium/calmodulin-dependent protein kinase
II (CaMKII). A series of experiments clearly showed that CaMKII is the clutch in a variety of scenarios involving myosin-V, Gelfand said. The two proteins are often found together in laboratory analyses. It is possible that CaMKII regulates myosin-...
Findings on cell communication may help fight three genetic diseases
... transmembrane proteins (Wsc proteins) and protein kinase
C (Pkc1p). Nanduri's present goal is to understand how Wsc proteins initiate signaling from the secretory path to the nucleus and how the several steps of this signaling are achieved. Tartakoff said their observations show that the organization of t...
New pathway to understanding circadian rhythms
...plicated a signal affected by NF1, namely, protein kinase
A, in circadian rhythm pathways in flies. Subseque...e corrected, or "rescued," by switching on protein kinase
A. "We found, however, that the ability of protein kinase
A to rescue the circadian rhythm abnormali...
Researchers find enzyme crucial to preservation of memories
...nation of the enzyme, calcium-calmodulin dependent kinase
(CaMKIV), in the forebrains of mice had profound e...studies implicating another enzyme, called protein kinase
A, in LTP. However, that enzyme was not specific to the protein-synthesis-dependent type of LTP. Wit...
DDR2 and hepatic fibrosis
...sponse. Transcription of DDR2, a receptor tyrosine kinase
that signals in response to triple helical collagen in the surroundings, is induced early during the activation of hepatic stellate cells. These mesenchymal cells are responsible for collagen I biosynthesis following injury, and Olaso et al. show th...
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