A decade later, gene discovered by Temple researchers found to be multi-functional
...id sequence that is similar in all members of this kinase family ( http://landesbioscience.com/journals/canc...d, one of the most interesting is the role of this kinase in cellular differentiation, particularly muscle differentiation. In practical terms, when we ...BIDMC researchers identify source of preeclampsia
... that a protein known as soluble fms-like tyrosine kinase 1 (sFlt1) was significantly elevated among the preeclampsia patients. With this information in hand, the researchers administered the protein to both pregnant and non-pregnant rats to test whether sFlt1 was at the root of the problem. "The resulting ...Researchers developing 'sentinel plants' to warn of bioterrorism
...e receptor (sensing part) of these proteins to the kinase (response part) of another protein that can induce visible responses. As a result, the researchers hope to develop plants that respond to all environmental stimuli in a predetermined and visual way. "When our work is complete, we'll have a 'kit' of s...Researchers develop strategy to predict mutations involved in cancer drug resistance
...evec binds to a specific pocket within the BCR/ABL kinase domain the part of the protein that regulates enzyme function. All mutations previously found in CML patients who relapsed while on Gleevec therapy have been found within that domain, most around the drug binding pocket. But once the Whitehead res...Studies of rare blood syndrome yield novel route to cancer
...n between two known genes could produce a tyrosine kinase that is essentially "turned on" in the absence of ...key inhibitors like Gleevec that selectively block kinase activity," said Gilliland. Although the broad range of standard analytical techniques now used to de...Fruit fly cells reveal Hedgehog's secrets
...uit fly genes, two -- dubbed Dally-like and casein kinase 1alpha (CK1alpha) -- had been associated with signaling by a protein called Wingless, whose effects are similar to Hedgehog. Dally-like protein is actually more critical in the Hedgehog pathway than in Wingless, they report. The third gene, caupolica...JCI Table of Contents, May 1, 2003
...and endothelial cells in the tumorvasculature with kinase inhibitors AUTHOR CONTACT: Gabriele Bergers UCSF, San Francisco, California, USA. Phone : 415-476-6786 Fax : 415-476-0388 E-mail: bergers@cgl.ucsf.edu View the PDF of this article at: https://www.the-jci.org/press/17929.pdf ACCOMPANYING COMMENTA...Systematic analysis of gene family uncovers new therapeutic targets for colon cancer
...olon cancers to identify mutations in the tyrosine kinase (TK) gene family. TK genes are thought be good the...ized therapeutics, based on mutations in different kinase genes and designed to match the mutated TK pathways present in each patient's particular tumor DNA."...Genetic reconnaissance identifies new colon cancer genes
...ave combed through a catalog of all known tyrosine kinase enzymes to identify new gene mutations that occur ...gelstein, genetic mutations can produce a tyrosine kinase that is essentially "turned on" in the absence of a normal activation signal, which is called consti...Diabetes in the elderly linked to fewer cellular 'power plants'
...se leads to more mitochondria by activation of AMP kinase -- by staying active, the elderly might well able to maintain mitochondrial content and head off such health problems," said Shulman. To test that possibility, the researchers also plan studies to compare mitochondrial activity in active and sedentar...Drug-resistant cancer outwitted by chemical flank attack
...e activity of the drug's main target, the tyrosine kinase enzyme. "Patients with a broad range of cancers t...e patient had acquired a mutation in the activated kinase PDGFR-alpha that causes HES. That mutation, they found, was analogous to a mutation that causes Glee...Lithium shows promise against Alzheimers in mouse model
... Nature. Inhibiting the enzyme, glycogen synthase kinase 3 alpha (GSK-3 alpha), also blocks formation of neurofibrilary tangles by the tau protein. "Although widely used to treat bipolar disorder, lithium's propensity to cause side-effects may limit its use in older people, who are more susceptible to ...Plants and people share a molecular signaling system, researchers discover
...s of discoveries, not only identifying sphingosine kinase as the enzyme that produces S1P in plants, but also demonstrating that S1P production is triggered by the stress hormone abscisic acid. During drought, this hormone initiates a chain of cellular events that ultimately cause a leaf's pores, known as ...Scientists find protein that controls prostate cancer's spread
...trong evidence that a protein called RKIP, for Raf kinase inhibitor protein, governs the ability of prostate...naling pathway that RKIP is involved in -- the Raf kinase system. They found that the cells with lower RKIP levels had higher levels of the activated form of ...Key regulatory enzyme is a molecular 'octopus'
...off-switch" -- called a G protein-coupled receptor kinase (GRK) -- reveals the protein as the molecular equivalent of a three-armed octopus, with independent segments capable of performing multiple regulatory functions at once. Kinases are enzymes that act as molecular switches by adding phosphates to other...American Society of Plant Biologists Annual Meeting 2003
...akers & Presentations: Michael Palmgren: "Receptor kinase mediated regulation of plasma membrane H+-ATPase" Sally Assman: "G protein signaling in plant cells" Bill Lucas: "Plasmodesmata: pathway for intercellular trafficking of macromolecules" Richard Williamson: "Cellulose synthesis" On Saturday, July 26 ...Mutant gene found to cause early ovarian failure in mice
...in cancer and aging. The network, known as the PI3 kinase pathway, is frequently commandeered to spur abnormal growth in cancer cells, said DePinho. Moreover, the same pathway has a role in regulating longevity in several species. Premature ovarian failure itself results in the early onset of several age-re......ols blood sugar and fat mass The serine/threonine kinase Akt/PKB has three mammalian isoforms: Akt1 (PKBa), Akt2 (PKBb), and Akt3 (PKBg). The three isoforms show broad tissue distribution, with the Akt2 isoform predominating in insulin-responsive tissues. Researchers at Pfizer have now generated Akt2 knock...