Emory researchers discover novel mechanism of how anthrax impairs immunity
... by disrupting the mitogen-activated protein (MAP) kinase enzymes within dendritic cells. Consequently, the dendritic cells become lethargic and unable to act normally, thereby preventing the activation of the immune system to attack microbes such as anthrax. "When a person is infected with a microbe, we c...Mutation may help cause acute myeloid leukemia
...a genetic defect in a molecule known as a tyrosine kinase receptor. The study is published online and in the...oth the aml1-eto defect and a defect in a tyrosine kinase receptor gene known as tel-pdgfrb. With these two mutations, the mice developed AML; mice with only ...$13 million grant boosts breast cancer research
...lead investigators include: HER (erbB) tyrosine kinase inhibitors in treatment-nave, operable breast cancer. One goal of is to identify which breast cancers respond to this type of drugs as well as surrogate markers predictive of EGF receptor inactivation in situ. (Arteaga and Dr. Mark Kelley). Predi...JCI Table of Contents, 15 August 2003
....the-jci.org/press/18107.pdf Integrin-linked kinase mediates kidney fibrosis Emerging evidence sugge...ession of the intracellular enzyme integrin-linked kinase (ILK) is specifically induced in renal tubular epithelial cells in response to TGFbeta1 and that ILK...Scientists map signaling molecule crucial to survival, disease
...uctions in the gene. A molecule known as a protein kinase ferries a phosphate-laden molecule to a specific a... designed to block the specific version of protein kinase that normally carries phosphate to that specific site. There are more than 600 different protein kin...Study provides new insights into emerging theory of gene regulation
... Marmorstein and his colleagues showed that when a kinase enzyme adds a phosphoryl group to a histone molecule at a particular location, it helps a histone acetyltransferase enzyme to add an acetyl group at a second location on the same histone molecule. The acetylation of the histone then is thought to pro...Researchers involved in renal and cardiovascular function gather for fall conference
...ot yet known. A new study reports that the protein kinase C (PKC) may contribute to the vasoconstriction of the penis' circulation, thereby reducing the erectile response, in obese, diabetic rats. (Dr. Wingard/Thursday PM) GENETICS AND KIDNEY CANCER Kidney cancer affects over 32,000 Americans annually...Obesity, kidney genetics, erectile dysfunction among highlighted research at APS Meeting
...ot yet known. A new study reports that the protein kinase C (PKC) may contribute to the vasoconstriction of the penis' circulation, thereby reducing the erectile response, in obese, diabetic rats. (Dr. Wingard/Thursday PM) GENETICS AND KIDNEY CANCER Kidney cancer affects over 32,000 Americans annually...Could a specific protein contribute to erectile dysfunction for the diabetic and obese?
...rictor agents. Their findings suggest that protein kinase C (PKC) may contribute to an enhanced vasoconstriction of the penile circulation and reduced erectile response. Constriction of the penile vasculature prevents erection and is largely mediated by two agents: -adrenergic agonists or endothelin (ET-1)...National Institutes of Health grant to Rensselaer to further research on healing bone injuries
...selected a specific protein, called focal adhesion kinase (FAK), a decision-making protein that may signal stem cells to become bone at an early stage of differentiation. The researchers hope that "turning on" FAK will be a chemical-free method of creating engineered bone cells that could be safely used in ...JCI table of contents, 15 October, 2003
...ficient in the LDL receptor and the enzyme IkappaB kinase 2, which is essential for NF-kappaB activation. The authors showed that NF-kappaB defective macrophages enhance, rather than inhibit, atherosclerosis. Lesions were larger in size, more advanced, and contained more necrosis, and early lesions containe...JAK2 enzyme helps protect brain cells, wreaks havoc on blood vessels
...east control the "bad" and "ugly." JAK2, or janus kinase 2, is an enzyme found in all cells that plays an important role in development and growth; mice lacking this enzyme die in utero, Dr. Marrero says. After birth, the enzyme becomes a two-edged sword that activates or deactivates other proteins and pla...OHSU researchers discover molecular signaling system controlling aspects of embryonic development
...urface receptor protein called anaplastic lymphoma kinase (Alk) in the late 1990s. All that was known about human Alk was that it could cause lymphoma if abnormally regulated; its normal function had not been determined. After initial publication of Weiss's research on Jeb, scientists at New York's Mt. Sin...New drug target and biomarker for advanced childhood cancer discovered
...ers reported data on the crystal structures of two kinase proteins implicated in multiple cancers. The data...stal structure of an inhibitor complex of Aurora A kinase and preliminary in vitro SAR analysis of quinazoline inhibitors: Abstract 446Scientists have discove...Three molecular-targeted compounds show promise against cancers
...to inhibit an enzyme, known as Raf kinase. The Raf kinase enzyme regulates tumor-cell proliferation and may also play a role in the growth of new blood vessels to feed the tumor. "The frequency of tumor shrinkage and disease stabilization is quite encouraging," said the study's lead investigator, Mark Ratai...Lab tests can reveal how patients respond to Gleevec
...eevec. Gleevec, technically known as a tyrosine kinase inhibitor, was first introduced for the treatment ...the growth of which is driven by a mutant tyrosine kinase enzyme called BCR-ABL. Gleevec is a potent inhibitor of the BCR-ABL enzyme, effectively shutting dow...Newly identified genes may help predict outcome in childhood leukemia
...f intracellular response) and activator of protein kinase C, which plays a pivotal role in cell signaling systems; and G2, an interleukin (IL)-10 receptor alpha, which regulates immune and inflammatory response. ALL cases expressing higher levels of these genes were associated with better outcomes. As th...Oral drug showing promise for breast cancer prevention in a mouse model
...n epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, blocks the cellular signaling pathway that contributes to tumor survival and growth, and studies have shown that ZD1839 is effective at inhibiting the growth of various types of cancer cells, including breast cancer cells. To test whether ...New study identifies inhibitor of anthrax toxin
...n to attack a family of protein kinases called map kinase kinases (MEKKs), which mediate many cellular responses, including cytokine release and cell survival. The availability of drug inhibitors may facilitate the understanding of the effect of lethal factor on these pathways. Protease inhibitor drugs have...Feeder-free system for maintaining pluripotency in embryonic stem cells pioneered
... when the new compound inhibits a specific protein kinase in embryonic cells, called GSK-3. This enzyme plays an essential role in many normal and disease states from development to neurodegenerative disorders. It is involved in numerous pathways including a highly conserved and important one called the Wn...