How an insidious mutation fools DNA replication
...malformations that distort the active site -- like kinks in the spaghetti strand that would clog the Cheerio. Such malformations trigger a repair mechanism to correct the mismatch. The researchers' initial studies revealed that the polymerase biochemically "prefers" to mismatch an 8-oxoguanine with adenin...Carnegie Mellon scientists create unique DNA probe with great potential
...nt years, scientists have found that DNA sometimes kinks or bends into unusual structures, such as hairpin turns, triplexes or quadruplexes. In the latter case, four DNA guanine (G) nucleobases align in a wheel-like structure (see Figure 1). DNA-quadruplexes recently have been found in complexes called tel...CWRU scientists demystify protein at root of arthritis
...at Case Western Reserve University have discovered kinks in aggrecan, a widely studied protein at the submo...ecan onto the human genome and discovered that the kinks in their images lined up with places where aggrecan gets degraded in osteoarthritis. The result pro...Biologists Get First Look At DNA-Protein Binding Structure In An Archaeon
...torts the DNA, is a very new finding. The protein kinks the DNA so that the DNA is sharply bent and stabilized." To get this new view, the researchers formed a single crystal of the proteinwith pieces of DNA from the archaeons Sulfolobus acidocaldarius and S.solfataricus. After freezing the crystal with ...