Scientists combine therapeutic cloning, embryonic stem cells, and gene defect in mice
...pendent research interests, the Jaenisch and Daley labs used skin cells from a mouse, which was completely immune deficient, to create a cellular therapy that was able to partially restore immune function in the mouse. "Though the immune system wasnt completely restored, there was enough improvement to pr...Scientists find they can tap gene-silencing process to reveal parts of genetic machinery
...was sequenced, and it is used by a several hundred labs around the world to study an incredibly diverse array of biological phenomena, including aging, cancer and cell death. Injecting pieces of laboratory-produced, double-stranded RNA into the worms, the researchers could silence just about any gene ...Prescription drug pollution may harm humans, aquatic life
...nd Venkatraman, will allow researchers in academic labs to test for the presence of particular drugs that may pose a problem in the environment. Blumenfeld, a senior majoring in chemistry, received financial support through a Johns Hopkins Provosts Undergraduate Research Award. As the project continues, J...Bug vs. bug: scientists use microorganisms to target destructive termites
...elop biological control agents for termites. Other labs are developing or refining similar techniques. However, Wright believes that her studies are producing more promising results to date. We still have a long way to go, she said, adding that the best weapon against these termites is probably an integr...New process speeds protein separation
...bman. "Anyone who has an HPLC---as pharmaceutical labs do---can set this all up themselves, totally automate the separation process, and have results in a very short time. In our work, we have separated out more than a thousand proteins in hours versus days." Because the proteins remain intact and are i...UT Southwestern researcher receives $15 million grant from Japan Science and Technology Corp.
...stein, chairman of molecular genetics. Each of the labs will be staffed by about 20 researchers. Yanagisawa will visit Tokyo several times a year and plans to set up frequent video conferences between the two labs. Yanagisawa is one of two researchers in the United States to receive a grant from Japan Sci...ACS's JobSpectrum to help state labs fill public health jobs; fight terrorism
...tories (APHL). After September 11, public health labs around the country were presented with hundreds of...s can be detected by biomonitoring. Public health labs are continuing to expand their biomonitoring capabilities for human exposure to toxic chemicals, inc...ORNL receives $21.7 million for DOE's Genomes to Life
...This is very much something for which the national labs are ideally suited because of their multidisciplinary teams and their exceptional analytical and computational capabilities." A key partner for the three-year $23.4 million project is Pacific Northwest National Laboratory. Together, ORNL and PNNL hav...Investigators use guilt-by-association strategy to track potential cancer causing genes
...mponents of many different cancer pathways. "Other labs are looking for collaborators of genes associated with different cancer pathways," Clurman said. "A huge database will be built based of this information, which will allow us to compare the sets of genes altered in different kinds of tumors. Gene dis...Joint Genome Institute to sequence key African frog genome
...together the research capabilities of the national labs and helps to convene multi-national teams that und...will provide additional resources to NIH-sponsored labs to add data for this collaborative genome project. JGI is a leader in sequencing organisms of cruci...Of mice and men: Deaf mouse leads scientists to new human hearing loss gene
...iversity of Iowa. "This shows what can happen when labs work together, because having the mouse gene definitely sped things up for those of us searching for the human gene." Kohrman credits the public mouse genome database for speeding his team's research. Both TMIE and Tmie are located on a stretch of DN...New mouse model shows how news of pathogen reaches immune system
...-lapse video from a pair of Harvard Medical School labs shows how pieces of captured germs may work their way to the surface of live dendritic cells. Dendritic cells are immune cells that alert other immune cells about invading germs. Inside a dendritic cell, the video shows, the molecules with the job of...Rad50 and the maintenance of genome stability
...hurdle. "We knew from previous work in a number of labs that mutations that completely abrogate DNA recombination and chromosome repair lead to early embryonic death. The trick here was to make a more subtle mutation, and to get a viable mouse," explains Dr. Petrini. In choosing their Rad50 mutation, the...Web-based collaboration links labs to supercomputers
...ning long-range collaboration and linking far-away labs to supercomputers -- for free. Currently more than 500 researchers are involved in more than 100 projects using the Biological Collaborative Research Environment for Structural Biology, or BioCoRE. Created initially with biomedical research in mind, ...New Stanford study casts doubt on developmental potential of adult stem cells
...search, in conjunction with recent work from other labs that also failed to verify adult stem cell plasticity, should dim the enthusiasm for pursuing research only in adult stem cells. "I hope it tempers the enthusiasm for adult stem cell plasticity. Maybe it's not the answer that it appeared to be," she ...Ambitious plan to give sight to the blind
...nanotechnologies in our multidisciplinary national labs offers possibilities for advances, where before people had hit brick walls." The Sandia approach is to attach a MEMs chip on the retina - that is, within the vitreous humor of the eyeball - made of LIGA and surface micromachined silicon parts. (LIGA,...Yeast research targets drug resistance battle
...nt often become drug-resistant. Researchers in the labs of Professors Jim Anderson and Linda Kohn of botany have determined how this happens by studying the yeast Candida albicans and its genetic changes when exposed to drugs. "Ultimately, our findings could lead to the development of companion drugs that...UCSF begins distributing the first of its two embryonic stem cell lines
...s in many laboratories, and the role of University labs in this effort is critical, as there is less need ... them, and training visiting scientists from other labs to grow the cells. The grant also funds some basic science studies on the cells. UCSF is currently d...Wrong proteins targeted in battle against cancer?
...hermore many inventive technologies from chemistry labs around the world give hope that this approach has great possibilities."...Transposable elements in malaria mosquito genome may offer a tool for control of disease spread
...re than a hundred researchers in more than a dozen labs contributed to this effort. The sequence was poste...rcent of the genome. Tu's group is one of several labs involved in characterizing transposable elements (TEs) -- segments of nucleic acids, or genetic mate...