University Of Pittsburgh Involved In First Successful Example Of Gene Therapy For Pain Control
... geneinside a herpes virus capable of establishing latency in the nervous system, astate where the viral genes are inactive while the enkephalin gene remainsactive. The researchers transferred the gene-containing virus to the paws ofmice, where it naturally infected sensory neurons, including those that res...U-M scientist discover how viruses hide inside human cells
...nd immunology in the U-M Medical School. "But the latency mechanism for these viruses has been a black box. Now we have a key that will get us in the front door." Using cultures of lymphoma cells infected with KSHV, Cotter and Robertson identified a protein called the latency-associated nuclear antigen or ...Gene therapy halts HIV replication in cells from infected patients
...itat gene offers the possibility of prolonging the latency period indefinitely without the need for long-term antiretroviral treatment," said Stuart E. Starr, M.D., chief of Immunologic and Infectious Diseases at The Children's Hospital of Philadelphia, and a co-author of the study. "Early indications are th...UC Berkeley biologist disputes current dogma that genetic mutation is the cause of cancer
...lmark of carcinogens is that they have a very long latency period," he said. "Scientists argue that this is because cancer is a multistep, epigenetic phenomenon, but that exactly describes aneuploidy." A major argument for aneuploidy over genetic mutation, Duesberg says, is that the cellular disruption cause......edge that further study is warranted. "Because the latency period for many cancers is 20 years or more, continued follow-up on the TMI residents will provide a more comprehensive look at their mortality, as well as morbidity, from various cancers," said Dr. Talbott. The University of Pittsburgh research team......egates in and around nerve cells could explain the latency of many neurodegenerative diseases, adds Kopito. The effects of aggregate formation can remain silent for a long time until aggregates build up to the point where onset of the disease occurs suddenly, he says. That may be why these diseases usually a...AIDS in Africa has potential to affect human evolution, UC Berkeley scientists report
...oup focused on a gene called CCR5 that affects the latency period for AIDS, that is, how long after infection...these genes would effectively lengthen the average latency by one year, from 7.8 years to 8.8 years. The frequency shift is primarily due to the opportunity fo......ssed with a maze and the results indicate that the latency period to find the platform was consistently signi... memory indicated no significant difference in the latency period. However, LA administration to six and nine month old SHRs, resulted in significant decline i...Stanford researchers identify genes involved in tuberculosis latency
...ng bacteria and bacteria that had been coaxed into latency in the lab. They identified 48 genes involved in t... including coughing. This delicate balance between latency and virulence seems to represent an uneasy truce between bacteria and host resulting from thousands ...B-vitamins prove effective in relieving chronic pain
...lgesia was determined by measuring foot withdrawal latency to heat stimulation of surface of hindpaw. The rat...esia (pain) evidenced by reversal of the shortened latency of foot withdrawal to noxious heat stimulation ipsilateral to CCD. This inhibition was in dose-depen...Sex-based and women's health research gain $150,000
...en respond well to pharmacological treatments, the latency of treatment response could have a deleterious effect on their infants' development. Escitalopram is a fast acting antidepressant, which can be used at lower doses than other Selective Serotonin Reuptake Inhibitors, but has not yet been used to trea...JCI table of contents, January 2, 2004
...sity of California, San Francisco demonstrate that latency in KSHV is unstable and results in segregation of ... The data indicate that acquisition of stable KSHV latency is a multistep process that is successful to varying degrees in different cell types. The report als...Alcohol consumption can damage hearing
... of brain currents, affecting the amplitude and/or latency of the current response, which can in turn be detected by means of BAEP." The results indicate that cumulative life-long alcohol consumption affects BAEP latencies, which reflect damage to central auditory pathways, which means hearing loss. "Not onl...Late invasion of infected cells into the brain causes HIV dementia say Temple researchers
...ojan Horse' model, it debunks the theory of a long latency in the brain by the infected cells," concludes Rappaport. "It suggests that trafficking of the macrophages late in infection is really responsible for dementia in HIV patients." Rappaport has recently received a five-year, $2 million grant from the...Sleepless over Seattle: Migrating songbirds forgo sleep but keep their wits
...e, "both depressed and manic patients show reduced latency to REM sleep, loss of slow-wave sleep, and reduced amounts of total sleep." Understanding the mechanisms that power the sleepless flight of songbirds promises to unravel one of the longstanding mysteries of their improbable journey. But it may also s...9/11 search-and-rescue dogs exhibit few effects from exposure to disaster sites
...life span of dogs often means a relatively shorter latency period for developing cancer. To assess the psychological wellbeing of the dogs, their handlers were given questionnaires that focused on behavioral disorders, such as aggression or fearfulness, which may have arisen since 9/11. Here also the ...