JCI table of contents, 1 July 2004
...the FLI1 gene effects cellular differentiation and leads to the disease state in Paris-Trousseau/Jacobsen t...: Adenovirus-mediated chronic "hyper-resistinemia" leads to in vivo insulin resistance in normal rats AUTHOR CONTACT: Jerrold M. Olefsky University of Calif...National Parkinson Foundation designates UNC as 'Center of Excellence'
...rrow, Alexander I. Trster and Daniel Kaufer, Huang leads UNC's translational research program in Parkinson'...gy and Research in UNC's Department of Psychiatry, leads the basic research initiative in Parkinson disease. Mailman is recognized as a pioneer in the therap...How DNA repair machinery is a 'Two-Way Street'
...achinery senses certain types of DNA damage, which leads to activation of the cell's suicide machinery, called apoptosis, resulting in cell death. Inactivation of the mismatch repair system not only predisposes cells to tumor development, but also renders them resistant to certain anti-tumor drugs. "Such f...UNC scientists discover molecular pathway leading to nerve growth and regeneration
... cord, where disruption of connections from injury leads to paralysis. "The results of this study allow us to know more about how to promote axon growth and regeneration in the spinal cord," said Dr. Fengquan Zhou, a postdoctoral fellow of the Spinal Cord Research Foundation who works in Snider's laborator...Clemson researcher places hope on pushy photons
... and a laser guides them out one by one. The beam leads them into another intersecting beam of higher intensity. The second beam then guides the cell to the target location. An understanding of cell communication can lead to new treatments for disease. For example, the heart is made up of billions of ...Joslin researchers identify key molecule in Type 1 diabetes progression
...e been trying to determine why insulitis sometimes leads to diabetes (so-called "destructive" insulitis) and sometimes does not ("respectful" insulitis). They know that certain T-cells called T effector cells promote destructive insulitis, and other T-cells called regulatory T-cells favor respectful insul...Inadequate vaccines can help breed more vicious malaria strains
...em to kill parasites but, unless a malaria vaccine leads to the death of every single parasite, the ones that survive are likely to be the nastiest. The new research by Dr Margaret Mackinnon and Professor Andrew Read, of the University of Edinburgh's Institute of Cell, Animal & Population Biology, sought t...Therapeutic cloning may be permitted at Newcastle University
... Dr. Miodrag Stojkovic of Newcastle University who leads the research team said that he was very happy that...chieved. Professor Alison Murdoch who leads the Newcastle Fertility Center at Life said that eggs would be donated for this research by patients...Lupus Research Institute awards $3 million in novel research grants to further new science in lupus
...Her investigations will look at the mechanism that leads immune complexes to stimulate B and T cells, which could characterize new genetic markers for lupus. Chander Raman, PhD, University of Alabama at Birmingham CD5: A NOVEL TARGET FOR TREATMENT OF SLE. Dr. Raman's research is focused on targeting ...JCI table of contents, 15 June 2004
...researchers found that a lack of PTEN in the liver leads to irregulation of metabolism in liver cells. In order to identify this new role, the authors created mice that had no PTEN gene specifically in the cells of their livers. These mice showed all the characteristic pathologies of a human disease calle...OneWorld Health CEO outlines mutually beneficial collaborations between industry, nonprofits at BIO
...harmaceutical scientists identifies promising drug leads and drives their development from pre-clinical studies to clinical trials through regulatory approval. The Institute for OneWorld Health, headquartered in San Francisco, Calif., is a tax-exempt 501(c) (3), U.S. corporation ( www.oneworldhealth.org )....Obesity and hypertension: Two epidemics or one?
...ypertension remains the tried and true method that leads to weight loss and other lifestyle modification....CSIRO research in greatest biotech show on earth
...ded. "It is important that our world class science leads to commercial outcomes for global benefit". Minister for Industry, Tourism and Resources, The Hon Ian MacFarlane MP, will lead the Australian delegation. The CSIRO delegation of 11 includes senior executives, scientists and business managers. "The at...U. Iowa muscular dystrophy discovery may lead to new treatment approaches
...ycan's ability to interact with other proteins and leads to muscle degeneration and brain defects in these muscular dystrophies. LARGE protein is mutated in patients with congenital muscular dystrophy 1D. In the Nature Medicine article, Campbell and his colleagues examined the effect of restoring expressio...Researchers establish first molecular link between eating and aging
...s to determine if an increase in Sirt1 in the body leads to a higher rate of metabolism. This research was funded by the National Institutes of Health....EMBL Director-General receives high German honour: the Bundesverdienstkreuz 1. Klasse
...eneral of the EMBL in 1993, Professor Kafatos also leads an active research group at the laboratory. His scientific achievements make him one of the world's most renowned experts in malaria research. Prof. Kafatos was instrumental in establishing the international consortium that determined the mosquito ge...With fat, women have a more visceral response
...c disease. The theory is that excess visceral fat leads to increased free fatty acids (FFA) being released into the portal vein, thus exposing the liver to higher FFA concentrations. Increased liver exposure to FFAs could effect production of triglycerides, such as VLDL, and have an impact on hepatic ins...JCI table of contents, 1 June 2004
...c disease. The theory is that excess visceral fat leads to increased free fatty acids (FFA) being released into the portal vein, thus exposing the liver to higher FFA concentrations. Increased liver exposure to FFAs could effect production of triglycerides, such as VLDL, and have an impact on hepatic ins...Tufts researchers identify a novel target for cancer therapy
...is a key step in tumor progression that eventually leads to metastases when a disseminated tumor cell penetrates through the extracellular matrix and establishes a secondary tumor site elsewhere. To date there are no effective and safe treatments against metastases due to the lack of reliable validated dr...Cell growth and death controlled by single pathway in lymphoma cancer model
...ormally involved in setting up an immune response, leads to abnormal proliferation." But the scientists al...s to grow, and abnormal activation of this pathway leads to abnormal proliferation and cancer," Stoffel says. "If this pathway also inhibits p53, which norma...