Transcriptional gene silencing in nucleus shown by UCSD/VA medical researchers
...herapy approach. UCSD researchers used either lentiviral vectors (molecular ferries) to open up the nuclear membrane, or special transfection reagents which direct the transfected synthetic siRNA to the nucleus. This allowed siRNA access to the promoter, where it stopped the first part of the gene-making p...JCI table of contents, 2 June, 2003
Turning foe into friend with lentiviral vectors Currently, there is no vaccine available ...or Cancer Research in Switzerland have developed a lentiviral vaccine which following injection into mice is capable of inducing an antigen-specific T cell respon...Turning foe into friend with lentiviral vectors
...or Cancer Research in Switzerland have developed a lentiviral vaccine which following injection into mice is capable of inducing an antigen-specific T cell response. This approach represents an attractive candidate for cancer therapy. The crucial stimulation of a T cell response is dependent on the presentation...Researchers engineer virus that blocks common genetic defect
..., the antisense sequences were incorporated into a lentiviral vector. "Lentiviral vectors appear to be the most...The use of antisense technology coupled with these lentiviral vectors allows us to propel this field forward in the treatment of hematopoietic disorders." In the...UF researcher develops AIDS vaccine for cats
...is will boost interest in the development of other lentiviral vaccines, including HIV. Dr. Steve Chu, senior vice president for global research and development at Fort Dodge Animal Health, called Yamamotos vaccine technology, a scientific breakthrough for lentivirus vaccine and disease prevention. Yamamoto fir...Gene therapy corrects sickle cell disease in mice, Science authors report
...venly through the cells, as it is in the case with lentiviral vectors, the gene can do its work," noted Leboulch. In two different models of sickle cell disease in mice, the gene therapy caused an eightfold reduction in sickled cells in one model, and elimination of sickled cells in the second model. Other char...New resources to assist with gene transfer clinical studies
...inistrative matters. The Indiana NGVL will produce lentiviral and retroviral vectors; maintain a generally accessible master file that contains toxicology data on adeno-associated virus (AAV), a commonly used vector; and establish a repository to distribute an AAV reference standard to investigators; City of......causes the symptoms of Parkinson's disease. "The lentiviral vector delivery system was effective in getting GD...anticipates that clinical testing in humans of the lentiviral delivery system for GDNF will begin in Switzerland and the U.S. in less than five years following re...Modified HIV may be effective for delivering and regulating gene therapy
...ctors based on HIV. "Another advantage in using a lentiviral vector is its large capacity," Kafri added. "It's ...uorescence. "These studies show that an inducible lentiviral vector can deliver and regulate transgene expression in vivo," the authors write. "We believe that r...