Researchers identify protein that overcomes leptin resistance
...les the body to overcome resistance to the hormone leptin could help scientists move one step closer to crea...sm at BIDMC, efforts made several years ago to use leptin in drug form to treat obesity were largely unsuccessful. The majority of obese people actually have...Children in lower socio-economic backgrounds at high risk for type-2 diabetes
...or necrosis factor-a (TNF-a), interlukin-6 (IL-6), leptin and resistin. Also of interest has been the recently discovered adiponectin, a peptide hormone derived from adipose (i.e., fat) tissue, which is one of several new hormones involved in obesity and is related to susceptibility to non-insulin dependent...Researchers discover molecular 'switch' that tells body to store or burn fat
...ed SCD-1 plays a crucial role through the hormone leptin in signaling the body to either store fat or burn... new information concerning the mechanism by which leptin regulates body weight and metabolism. Obese, leptin-deficient mice with mutations in SCD-1 lost weig...Research identifies enzyme involved in fat storage
...dman and his colleagues reported that the hormone leptin represses a liver enzyme called stearoyl-CoA desat...h team cloned the ob gene in 1994 and discovered leptin in 1995. Since then, much of Friedman's research has focused on understanding how leptin exerts its ...UCLA scientists discover hormone may spur dramatic weight loss
...mutation that prevents their bodies from producing leptin may open the door to a new way of fighting fat. After injections with leptin -- a human hormone linked to appetite control -- the adults' dramatic weight loss suggests that lept...JCI table of contents, October 21, 2002
...jci.org/press/16941.pdf Beneficial effects of leptin on obesity, T cell hyporesponsiveness, andneuroend...tin administration. Much less is known about human leptin deficiency. I.Sadaf Farooqi and colleagues previously reported on 2 children withcongenital leptin d...New mouse model sheds light on lipoatrophic diabetes
...se model of lipoatrophic diabetes, and highlighted leptin therapy as a successful tool to combat this rare f...he administration of the fat cell-secreted protein leptin suggesting that leptin therapy may also prove successful in the treatment of humans with lipoatroph...JCI table of contents, December 15, 2002
.... In addition, theyhave increased levels of plasma leptin and insulin, exhibit resistance toboth hormones, and show decreased levels of histamine and increasedhistamine turnover in the hypothalamic and thalamic brain regions. Theseresults demonstrate a critical role of H3 receptors in the control of bodywei...Could an anti-marijuana compound hold the key to body weight and appetite control?
...ease, was reported. Specifically, a deficiency of leptin has been found in obese animal subjects. SR141716 has been shown to induce a significant decrease in food intake and body weight gain and reduce the intake of a high fat diet in these obese rats. Now, a new research effort seeks to assess the effec...Takeda Chemical Industries and Beth Israel Deaconess announce research agreement
...ng extensively investigated the molecular basis of leptin resistance in obesity, the cellular and molecular mechanisms for insulin resistance in diabetes, and the role of the brain to hunger and satiety. Over the past year alone, these investigators have published more than 45 papers in the world's leading ...UCSF study suggests novel factor could contribute to adult obesity
...e, fat metabolism, skeletal muscle oxygenation and leptin signaling. If this proved the case, a drug that stimulated the serotonin 5-HT(2c) receptor might decrease the energy efficiency of physical activity, says Tecott. He and his colleagues now are testing this possibility in normal mice. Notably, seroton...Obesity not a personal failing, but a battle against biology
...aboratory team that discovered the obesity hormone leptin in 1995. "Nor can we hold to the simple belief tha...n when to stop eating. As body fat increases, more leptin is produced, which acts to reduce food intake. As body fat decreases, less leptin is produced, which...Experimental Biology 2003 meets in San Diego April 11-15
...g symposia on novel signaling pathways involved in leptin action and regulation of energy balance and novel mechanisms for insulin resistance; and how the rapidly emerging fields of genomics, proteomics and bioinformatics contribute to our understanding of cardiopulmonary and other diseases. The American ...Baboon behavior offers clues in the all-too-human battle of the bulge
...at ate the food discarded by people and had normal leptin levels, indicating that high cholesterol and obesity might be controlled by different factors. "They're probably two separate but inter-related aspects. This may be telling us they segregate more than we thought," Banks says. "This is a unique natur...Body hormone ghrelin, a food intake and weight gain influence, is found to promote sleep
...hrelin on sleep EEG and of GH, ACTH, cortisol, and leptin in healthy male subjects. The authors of "Ghrelin Promotes Slow-Wave Sleep in Humans" are J. C. Weikel, A. Wichniak, M. Ising, H. Brunner, E. Friess, K. Held, S. Mathias, D. A. Schmid, M. Uhr, and A. Steiger, all from the Max Planck Institute of Psy...Understanding obesity: New research examines how hunger signals work in the brain
... Pharmaceutical Design. Normally, a protein called leptin is released from fat cells and hitches a ride acro...blood-brain barrier doesn't properly transport the leptin or because the brain isn't interpreting the signals properly. William A. Banks, M.D., professor of g...JCI Table of Contents, May 1, 2003
...he-jci.org/press/15211.pdf The role of falling leptin levels in the neuroendocrine and metabolicadaptation to short-term starvation in healthy men AUTHOR CONTACT: Christos S. Mantzoros Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. Phone: 617-667-2151 Fax: 61...Can female adult obesity be stopped at birth?
... neuropeptide. For example, pancreatic insulin and leptin released by adipocytes have been reported to suppr...t three days of age, with no change in glucose and leptin concentrations. This hyperinsulinemia persisted until 120 days of age in the female progeny, with co...Natural hormone could reverse heart damage
... Progressive obesity developed in the mice lacking leptin or its receptor, and by 6 months of age, researche.... Two groups were assigned to lose weight (one by leptin infusions and one by a calorie-restricted diet), while the third group continued to eat its regular ...COX-2 inhibitors and renal damage in obesity-related Type II diabetes
...e renal damage. Obese Zucker rats possess a mutant leptin receptor that explains their uncontrolled appetite and, consequently, results in obesity and its associated characteristics (insulin resistance, hypertension, etc.), although the mechanisms responsible for renal damage in the Obese Zucker rat remain ...