JCI table of contents, February 2, 2004
...rophy, the authors observed that administration of leptin under the skin was not as potent as lower doses ad...d repression of the enzyme SCD-1 as a mechanism of leptin action to improve fatty liver degeneration. These findings may have profound effects on the progress...UT Southwestern researchers find leptin turns fat-storing cells into fat-burning cells
...was found two weeks after researchers injected the leptin gene. Findings from the study will appear in an up...e first careful examination of the fat cells after leptin therapy," said Dr. Roger Unger, director of the Touchstone Center for Diabetes Research at UT Southw...UT Southwestern researchers cite recent advances in underlying causes of rare body-fat disorders
...tes of Health, reported that replacing the protein leptin drastically reduced triglyceride levels and controlled diabetes in patients with generalized lipodystrophies. In 2003 a novel gene, ZMPSTE24, linked to generalized loss of body fat and skeletal disorders, was identified. There are two categories ...Fat hormone leptin alters brain architecture and activity, which in turn drives feeding behavior
...h investigators at Yale University have found that leptin --- a hormone found in fat tissue and critical to ...rsity. The Rockefeller scientists discovered that leptin acts by changing the wiring of the brain, a phenomenon known as plasticity. The hormone alters the w...Leptin rewires the brain's feeding circuits
...iversity show that the appetite-regulating hormone leptin causes rewiring of neurons in areas of the brain t... The discovery is another important clue about how leptin exerts its effects on the brain to cause decreased food intake and increased energy expenditure, sai...OHSU researchers discover possible connection between infant hormone exposure, obesity
... discovered a link between exposure to the hormone leptin early in life, and brain formation that likely imp...bout this finding because it shows how exposure to leptin can directly affect development of brain structures involved in regulating body weight," said Richar...New studies show Curves Program raises metabolic rate in overweight and sedentary women
...arkers such as blood lipid levels, relationship of leptin to weight loss, insulin sensitivity, quality of life and body image. "The data showed impressive improvements in many of the markers tested. Additional studies are ongoing to look at further results of the Curves program on all aspects of quality of ...Fat cell hormone causes weight loss
...t, which was very fascinating because we knew that leptin caused weight loss by suppressing appetite and inc...s. The researchers found that both adiponectin and leptin require the melanocortin pathway in the brain to control body weight and glucose. However, these fat...Study detects protein in human milk linked to reduced risk of obesity
...e." The researchers also confirmed the presence of leptin in human milk. Leptin is another protein produced...in levels, however, are substantially greater than leptin in human milk, according to Dr. Martin, a researcher in the Center for Epidemiology and Biostatistic...Fat fighting undermined by over active eating pacemaker
... hormones like ghrelin, released from the gut and leptin from fat cells. The combination of these signals and their integration by the ARC pacemaker is such a finely balanced mechanism that one small error or mutation leading to any inappropriate communication in these pathways could produce a significant...Researchers establish first molecular link between eating and aging
...ase." Because WAT also makes hormones, especially leptin which controls satiety, Guarente speculates that by putting hormones into the bloodstream, fat cells also tell the body how fast to age. "Conversely, fewer fat cells tell the body that it's time to hunker down for survival. This means that evolutio......etened beverage, circulating levels of insulin and leptin were decreased compared to when the women ate the same meals accompanied by the glucose-sweetened beverage. Lower levels of insulin and leptin, hormones that convey information to the brain about the body's energy status and fat stores, have been li...Gestational diabetes not found to alter the metabolic processes in obese pregnant women
..., because the role of the increased maternal serum leptin (a helical protein secreted by adipose tissue and ...h team examined the relationship of maternal serum leptin changes in nutrient metabolism. The authors of the study, Longitudinal Changes in Energy Expenditure...Evidence for fat hormone target in brain
...ave presented direct evidence that the fat hormone leptin affects a specific type of target neurons in the b...gh researchers had produced indirect evidence that leptin affects the activity of particular neurons called POMC neurons in the brain, there had been no direc...Mice with hyperactive Wnt10b gene eat all they want, but have half the body fat of normal mice
...o says. "Adipose tissue produces proteins, such as leptin and adiponectin, which affect the body's ability to respond to insulin. Reduced insulin sensitivity is one of the first symptoms of diabetes. So having little or no white fat is just as devastating to your health as having too much fat." "Even though...Basic RNA enzyme research promises single-molecule biosensors
... a tool, "you could detect how a single cell makes leptin and ask how much the cell makes when the environment changes," he said. In another project, funded by NASA, the researchers hope to develop a biosensor that could be sent to Mars to snoop around for amino acids or other signs that life might once hav......se tissue. At the same time, basal blood insulin, leptin and triglyceride levels, and glucose tolerance were improved. Calcium balance was not affected by a high intake of milk proteins. Moreover, in contrast to what has generally been admitted, no adverse effects of the high protein diet were reported, pa......-- For nearly a decade, scientists have known that leptin plays an important fat-burning role in humans. But...oness Medical Center. The research team found that leptin triggers production of the active form of a peptide MSH in the hypothalamus, the small area in the......form; this is called prohormone processing. While leptin is known to regulate energy balance by controlling...l School and Rhode Island Hospital, theorized that leptin might have an additional layer of control, by regulating the production of the enzymes that are used......es. "What we have is an important discovery of how leptin regulates specific enzymes," Nillni said. "While s...nd energy use. Nillni and the team found that when leptin moves through the bloodstream to the brain, it travels a direct path to make more PC1 and PC2, which...