Mutate Or Die: New Polymerase Gives Desperate Yeast An Option
...ymine-thymine dimer,a very common and well studied lesion created when sunlight hits an organism, causing two bases to link up unnaturally.The abnormality almost always stops other polymerases dead in their tracks, but zeta went past the dimer about 10percent of the time. "Ultraviolet damage to DNA is...Induced Mutant Mouse Models Of Lipoprotein Disorders And Atherosclerosis
... examinenutritional and pharmacological effects on lesion formation and progression. Note to reporters: This is one of four fact sheets about the symposiumpresentation. News release also available. Contact: 214-706-1340....Virulent Fungus Devastating Potato Crops
... researchers note that each individual late blight lesion can produce as many as 300,000 sporangia a day. Some infected tubers may be destroyed before harvest, but with a multiplicity of virulent spores, harvested potatoes can easily become diseased in storage. Bacteria that cause soft-rot diseases often ...Soy Phytoestrogens Reduce Carotid Atherosclerosis As Much As Premarin
...ionof internal carotid artery atherosclerosis, the lesion site most commonlyassociated with cerebrovascular symptoms of human primates," Clarkson said. Clarkson and Mary Anthony, research associate in the Department ofComparative Medicine, compared the effects of treatment with mammalian estrogens-...Obscure Enzyme May Play Major Role In Heart Disease
...d, in parallel inthe mice, reduced atherosclerotic lesion size was demonstrated. "But dietary antioxidants may not be enough," Dr. Aviram says. "Undercertain conditions, the oxidative stress in the body is so great that itoutpaces the activity of the antioxidants. Thus, the combination of preventin......orts the hypothesis that BPH is not a premalignant lesion inthe development of prostate cancer," said Dr. Scher. The research built on the previous work of the study's co-authors, Dr. JoanMassagu and Dr. Andrew Koff of the Molecular Biology Program. Dr. Massagu wasthe first to isolate and clone the p27 pro...New Anti-Microbial Agent Destroys Anthrax
...n hour after exposure had a 95 percentreduction in lesion size. The death rate for mice receiving BCTP was only 20percent. "Rapid inactivation of anthrax bacteria and spores combined with low toxicitymakes BCTP a promising candidate for use as a broad-spectrum, post-exposuredecontamination agent," Baker sa...Sex-Specific Behavior Controlled By Peripheral Nervous System
...volved a complicated procedure that createda brain lesion on pre-natal ferrets. Weissburg's study, however, produced a greater number of specimenanimals because of the relatively easier task of transplanting, he said. A greaternumber of specimens yields more definitive results. "Dr. Wei...UB Researchers Identify Specific Oral Bacteria Most Likely To Increase Risk Of Heart Disease
...g, 2) accumulating arounddamaged tissue, such as a lesion in the blood vessel or a replaced heart valve,which also can narrow blood vessels and cause clots, and 3) inducing plateletsto aggregate, which increases the chances of clots forming. "We've known for some time that oral bacteria can precipitate thes...USGS Finds That Mysterious Arkansas Bald Eagle Disease Has Spread To Ducks In Eastern States
...r. John Fisher, a SCWDS pathologist, confirmed the lesion in aNorth Carolina mallard and ringnecked duck, and a Strom Thurmond Lake baldeagle. USGS wildlife disease specialist Dr. Kimberli Miller said that afflicted birdstypically fly erratically or are unable to fly; they may crash land, swim tippedto on...Dietary Carotenoid Lutein Reduces Atherosclerotic Lesion Formation In Mice
...ant lutein cansignificantly reduce atherosclerotic lesion formation in mice, according to astudy presented t...n-enriched diet had significantly reduced arterial lesion area. Mice that are "null" or deficient in apoE develop atherosclerotic lesions veryrapidly in th...Damaged spinal cord found to have greater potential for nerve regrowth than thought possible
...om the injury." When the researchers looked at the lesion site, they saw proteoglycan molecules, which Silver's laboratory has stronglycorrelated in past studies with the cessation of axon growth. In this study, Davies said, "Not only do the regenerating axons stopupon reaching the scar, but they change the...UT Southwestern researchers discover structure of molecule that repairs sun and cigarette damage
...andseparates them. Then the NER system incises the lesion on each side and disposesof it. The UT Sou...ggested that NER recognizes damage because ofhow a lesion affects DNA flexibility rather than because of its chemical makeup. This model, if proven, w...Bone produced from skin and gum tissue
... warm, says Rutherford. Injected as liquid into a lesion of any size or shape, the material gels as it warms to body temperature, holding the engineered cells in the appropriate place. In another set of experiments reported in the paper, the researchers implanted engineered human gingival cells into a stra...UF researchers find painless electrical stimulus helps restore hand movement for stroke patients
...t show significant improvement. The nature of the lesion in the brain that caused the stroke can be so severe that the signals from the brain to the muscles that straighten the elbow and raise the wrist and fingers are profoundly impaired or inhibited, said Dr. Steven Wolf, professor and director of the cl...Research shows radiologists will need different programs for digital mammography to work best
...e did our study, we thought that a certain type of lesion and a certain kind of breast density, for example, would require only one type of processing," said Pisano, also chief of breast imaging at UNC-CH and a member of the UNC Lineberger Comprehensive Cancer Center. "Now, we think displaying images will b...Evidence links protein damage to Parkinson's
...major component of Lewy bodies, the characteristic lesion in Parkinson's disease. The University of Pennsylvania scientists conducted a series of biochemical tests to determine whether nitrated alpha-synucleins are present, how abundant they are in Lewy bodies, and where they could be found, as well as ...Lymphocytes in early atherogenesis
... al. have now revisited this question by following lesion progression in the atherosclerosis-prone LDLR-/- m...iet, but the authors find that the early events of lesion growth are slowed in double knockout mice. These findings are at odds with some earlier studies tha...Cardiac stress tests may indicate if blockages will recur after angioplasty with stent implant
...ny defects. Four patients (13%) underwent target lesion revascularization, ie, an additional balloon or stent angioplasty procedure or coronary bypass surgery to clear up recurrent blockages. Half of these restenotic events took place in patients with residual ischemia after stent implantation. In additi......e is very likely to be a cancer or a pre-malignant lesion in the patient's colon or rectum." Physicians may one day combine the APC test with another test designed to detect mutations in a gene called BAT26 that Vogelstein and his colleagues will report in the February 2, 2002, issue of the British medi...