New Cancer Switch Discovered By Duke Medical Center Pharmacologists
...d Cortez reported success in halting the growth of leukemia cells by jamming their growth machinery. The resea...l gene called BCR-ABL, which produces two forms of leukemia -- chronic myelogenous leukemia and acute lymphoblastic leukemia. The BCR-ABL gene forms when a gene...ORNL Mice Helping Researchers Isolate, Identify Causes Of Cancer
...uesknow that the mice get cancer because of murine leukemia retroviruses. "One way these retroviruses can caus...he retrovirus. In addition to her work with murine leukemia retroviruses, Justice hasdiscovered a direct correlation between Chediak Higashi Syndrome in humanst...Laser Microscope At Cornell Images Serotonin In Live Cells
...or. For these studies, the researchers used basal leukemia cells from rats. "This three-photon excitation produces very high energy corresponding to shorter absorption wavelengths than was possible before, without killing the cells," Webb said. "All you could see before this technique was diffuse brightness...Researchers Corral Millions Of Microscopic Membranes
...ication is cell screening of the type required for leukemia patients. Doctors must closely monitor the different kinds of cells in a leukemia patient's blood. Using a small wafer holding millions of micro-patches that have been seeded with pr...Pharmaceuticals Manufactured In Insect Larvae
... fought include human papillomavirus, human T-cell leukemia virus, hepatitis-C virus, Norwalk virus, rotavirus, porcine parvovirus and African swine fever virus. BTI researchers do not directly study these diseases. Producing proteins through insects was seen as an alternative to raising proteins in cell cu...Gene Therapy Trial Takes Aim At Deadly Brain Cancer
...transfected with a genetically engineered mouse leukemia virus that includes the herpes simplex gene for thymidine kinase. This genetically engineered “composite” virus will infect nearby dividing cells, but has been rendered incapable of dividing itself. During surgery, after t...ACS Aids Cornell Vet School Cancer Research
... that underlies several forms of cancer, including leukemia and breast cancer. The study focuses on one protein, Cdc42Hs, that is a "biological switch" in growth-factor signaling pathways. By determining the three-dimensional structure of the switching protein, Cornell researchers hope to explain more about...3-D Structure Of HIV Components May Pave The Way For New Anti-AIDS Drugs
...o may accelerate drugdevelopment for some types of leukemia and other retroviral diseases. Other contributors to the work are Roberto N. DeGuzman, Zeng Rong Wu, andChelsea C. Stalling of UMBC and Lucia Pappalardo of Syracuse University....UPCI Researchers Find Drug Improves Cancer-Fighting Ability Of Vitamin D
...viously shown the effect of vitamin D analogues in leukemia cells, Dr. Johnson and Dr.Trump were among the first to demonstrate the efficacy of these agents against solid tumors such as prostate cancer and head and neck cancers. Currently, the UPCI team is conducting a clinical protocol combining a steroid w...Memorial Sloan-Kettering Investigators
...o the fundamental mechanisms underlying one formof leukemia have learned how to interfere with the genetic cha...e molecular geneticsunderlying acute promyelocytic leukemia (APL), a type of leukemia that afflicts2,000 to 3,000 Americans each year and has an especially abru...New Gene Alteration Find Points To Aggressive Leukemia Treatment
...OLUMBUS, Ohio -- Researchers looking at a group of leukemia patientshave found that a genetic defect they discovered two years ago serves asan early warning signal, calling for a speed-up in these patients’treatment. The defect is a duplication of a small part of the ALL1 gene. Patientswho have th...Hormone Control Of Rare Leukemia Sheds Light On Molecular Basis Of Cancer
...hebiochemical mechanism behind acute promyelocytic leukemia (APL), theysimultaneously elucidated a process implicated in many other cancers. APL is abone marrow cancer that strikes about 3,000 people in the United States everyyear. "This study gets at the exact biochemical and genetic cause of theunc...Chromosomal Abnormalities Key For Prediting Leukemia Outcome
...emia (AML). This was the first large group of AML leukemia patientsfor which information on chromosomal abnor...abnormalities present. For example,patients whose leukemia cells showed a loss of, or damage to, one of thetwo copies of chromosome 5 or 7 had a median surviva...Retinoic Acid Used In Cancer Treatment
...en used by Cornell University researchers studying leukemia to block the uncontrolled cell division that leads...-tune the chemotherapy cocktails given not only to leukemia patients but also to patients with other types of cancer, Yen suggests. "In the meantime,"...New Tests Demonstrate MuchLarger, More Specific Immune Responses To Viruses
...BV(infectious mononucleosis), HIV and human T cell leukemia virus type 1 (HTLV-1),all of which are characterized by massive increases in the number of CD8+ Tcells. "It is likely that most of the expanded CD8+ T cells in these infectionsare specific to those particular viruses also," he says. D...Report On Electrical And Magnetic Fields Released; Public Invited To Comment At Regional Meetings
...ver study whichappeared to show that children with leukemia were more likely to have residedwithin 131 feet of a power line than other children. More than 13 other similar epidemiological studies have subsequentlybeen carried out to test this hypothesis, with mixed results. But thescientific panel fo...Scientists Find New Clues About Fatal Childhood Disease, Ataxia Telangiectasia
...lude a greatlyincreased risk of cancer, especially leukemia and lymphoma; an unusually highrisk of diabetes and lung infections; and telangiectasia, or dilated bloodvessels in the eyes and other parts of the face. People with A-T usually die ofrespiratory failure or cancer by their early twenties. Carriers ...Hutch Researcher Wins 'Nobel Prize Of Applied Research'
...used in the Retro-X System is derived from a mouse leukemia virusthat has been modified, or "crippled," so tha...ng cell line because it was new, this sortof mouse leukemia virus hadn't been used for packaging lines before, andbecause the virus it produces can recognize tw...40 Percent Of Deaths Are Environmental
...line component, the carcinogen benzene that causes leukemia even at low dosages, rose from 0.5 billion kilograms in the United States in 1950 to current levels of about 7.5 kilograms per year. -- The global use of agricultural pesticides rose from about 50 million kilograms a year in 1945 to current applicat......uced remission in patients with acutepromyelocytic leukemia (APL), prompting physicians in the West to underta...Warrell, Jr., the senior author of the study and a leukemia specialist atMemorial Sloan-Kettering Cancer Center. In the pilot study, 12 patients who had relaps...