Scientists make a BID towards understanding chronic myelomonocytic leukemia
...hyperplasia) and ultimately succumbed to a form of leukemia closely resembling human chronic myelomonocytic leukemia (CMML). In fact, by 27 months of age, 73% of BID-deficient mice developed CMML. Human CMML generall...Bone marrow generates new neurons in human brains
...one marrow transplants had been performed to treat leukemia and other non-neurological diseases, and the patients survived from 1 to 9 months after their transplants. The investigators searched the autopsied brain tissue for male cells, which contain a Y chromosome. The Y chromosomes in these cells served a...Bone marrow cells take on new role in the brain, say Stanford researchers
...om women who underwent chemotherapy to treat their leukemia and then later received bone marrow transplants from male donors. These samples were ideal for this experiment because the donor cells contained a Y sex chromosome whereas cells in the women contained only X chromosomes. Any Y chromosome that Blau an...UT Southwestern researchers developing new procedures to make bone-marrow transplants safer
...lls that respond to the patient's normal cells and leukemia cells. "The goal is to get rid of the T cells that cause damage and save the beneficial ones," Vitetta said. "Even though we're in the early days, both in the clinical trials and in the laboratory research, this is very encouraging. "Importantly, it ...Modified zebrafish may point the way toward T cell leukemia genes, aid in drug development
...ting for genes responsible for acute lymphoblastic leukemia have a new compass: a system that uses powerful ge... or delay the spread of T cell acute lymphoblastic leukemia (ALL), a disease responsible for 400 deaths - about half of them, children - in the United States ea...Relapse or remission? Pharmacogenomics draws the fine line
...etween patients with childhood acute lymphoblastic leukemia (ALL) who relapse after treatment, and those who are on their way to cure. Leukemia is a "constellation of diseases at the molecular level," Evans says, because this cancer of the blood and bone marrow has many different subtypes. This makes treatm...JCI table of contents, March 3, 2003
....the-jci.org/press/18016.pdf Chronic myelogenous leukemia shapes host immunity by selective deletion ofhigh avidity leukemia-specific T-cells CONTACT: Jeffrey J. Molldrem University of Texas M.D. Anderson Cancer Center Department of Blood and Marrow Transplantation Section of Transplantation Immunology 151...Researchers develop strategy to predict mutations involved in cancer drug resistance
...ne that causes this rare form of leukemia. "In the leukemia cells of a CML patient, BCR/ABL is constantly muta...e drug and continue to grow while the remainder of leukemia cells are suppressed. We have found a way to discover those mutations experimentally." In studies re...A subtle tool to study mankind's diseases
..." The gene that they chose is called mixed-lineage leukemia (Mll), and is known to become defective in childhood leukemias in humans. By inserting the artificial version into the mouse, researchers hope to understand how the defects lead to disease."There are many things that can go wrong in this gene," Testa...Researchers find protein mechanism for potential atherosclerosis development
... a drug used successfully to treat chronic myeloid leukemia significantly reduced the development of the vessel abnormalities that lead to atherosclerosis. In cancer cells, Gleevec blocks certain signals and prevents a series of chemical reactions that cause cells to rapidly grow and divide. We effectively f...Programmable antibodies-- hybrid cancer therapy described by scientists at Scripps
...uman diseases ranging from rheumatoid arthritis to leukemia because they are designed to target particular cells and attract other parts of the immune system to the site. There are a dozen antibodies that are approved as therapeutics by the U.S. Food and Drug Administration, and many more under development. T...Researchers identify gene for premature aging disorder
...ndocrine neoplasia type 1, one type of adult acute leukemia and Alagille syndrome....St. Jude researchers use DNA chips to determine how leukemia cells respond to different drugs
...erapy treatments. The genes were identified in the leukemia cells of children undergoing chemotherapy for acute lymphoblastic leukemia (ALL). The researchers say this finding is a significant step in the emerging field of pharmacogeno...Borrowing from Ebola virus could aid cystic fibrosis gene therapy
...dified feline immunodeficiency virus, which causes leukemia in cats but no disease in humans. When the hybrid virus is delivered to airway cells, the modified Ebola protein acts like a key that fits into a lock, or receptor, on the top surface of the airway cells. Because the protein piece can "fit" onto the ...Genetic reconnaissance identifies new colon cancer genes
...he tumor? Gleevec works so well in chronic myeloid leukemia because it turns off a tyrosine kinase that dramatically reverses the cancer process."......ient at the Universityof Pennsylvania and cases of leukemia in two French children beingtreated for "Bubble baby syndrome." When the lipid/DNA globule is taken up by a cell, it's moved to anacid-filled compartment called the endosome. A key step, Nantz said,is to engineer lipids that can get the DNA out of th...Drug-resistant cancer outwitted by chemical flank attack
...roven highly effective in treating chronic myeloid leukemia (CML). And in a recent research article, Gilliland...liland, "after about three months on the drug, his leukemia began to recur. We were concerned that he had developed a resistance mutation to Gleevec because res...Neural stem cells take a step closer to the clinic
...cell lines by adding a signaling chemical known as leukemia inhibitory factor to the medium in which the cells were grown. The cells were then subjected to "gene chip" analysis, a powerful method for scanning the activity of thousands of genes at once. Nearly 33,000 genes were monitored across the three cell ...UT Southwestern researchers find immune system stages for eliminating viral infections, cancer cells
... the reactivity of NK cells in particular against leukemia is currently mediocre. Leukemia is a cancer of the bone marrow and blood characterized by the uncontrolled accumulation of blood cells. "Our ability to regulate the function of these cells could allow us to manipulate the immune system in new ways ...NHGRI study may help scientists develop safer methods for gene therapy
...ve that the children in the French study developed leukemia because the MoMuLV inserted therapeutic genes next to a gene known to promote blood cancer. Previously, researchers believed that MoMuLV randomly integrated into the genome of target cells. But scientists lacked the means to study these integration e...