Tag: "levels" at biology news

JCI Table of Contents, 15 July 2004

... in the absence of any PDE breakdown of cAMP, cAMP levels were substantially higher and that the developing eggs were frozen at a stage just prior to the completion of meiosis. The researchers then showed that by blocking the activity of another protein in the cAMP molecular signaling pathway, egg maturati...

Genetic model for devastating form of paraplegia suggests new treatments

...urons and analyzed the effects. Animals with lower levels of D-Spastin were weak, exhibited coordination def...ed communication properties. Flies with heightened levels of D-Spastin were also sick. High levels of over-expression caused embryonic death. Lower levels cau...

When male fish hum, females swim in, thanks to hormones, adaptable hearing

...roductive females, the researchers boosted hormone levels that alter the fish's inner-ear hearing sensitivit... team headed by Andrew Bass, found that a spike in levels of the hormones testosterone and estradiol (an estrogen) triggers changes in the females' inner ear ...

Hormone helps fish to mate, may affect human hearing

... of humans. The biologists experimentally boosted levels of the steroid hormone in non-reproductive females...ke beautiful small fry." Altering steroid hormone levels did not change the reproductive status of the females; the eggs they carried were still immature and...

Acamprosate: potential medication for treating alcoholism

...r effects of the alcohol as well as breath-alcohol levels at baseline and at 30-minute intervals for three h... of alcohol, for example, increasing blood alcohol levels that would make the person more intoxicated per unit of drink consumed, or increase levels of intoxi...

Most Americans not sure about the sources of high cholesterol

...a effort to be as informed about their cholesterol levels as possible. Knowing about the sources of cholest...tural chemistry can often produce dangerously high levels of LDL ("bad") cholesterol based on heredity alone. When working with a physician to manage your co...

Oxygen sensing in worms may hold key to healthy blood pressure in humans

...d stable supply of oxygen, maintaining the correct levels in our bodies is a relatively routine task. For or... that live in soil or water, however, where oxygen levels can fluctuate wildly, the task is far more challenging -- and pretty much of a mystery, until now. ...

Secret behind hard exoskeletons, spreading wings revealed

...ntified for bursicon. To determine that decreased levels of bursicon were responsible for the defects to th... test previously used to demonstrate that bursicon levels in the central nervous system are responsible for shell hardening and pigmentation. The shells of bl...

When sun's too strong, plankton make clouds

...ut plankton numbers are at their lowest. "Plankton levels are at a minimum in the summer but DMS is at its p...ons where there are low nutrients in the water and levels of UV light are high, plankton create more DMS. DMS levels peak from June through the end of Septem...

Molecular traffic cop directs cellular signals

...activated ERK from entering the nucleus. When hSef levels were experimentally reduced, stimulus-dependant ERK activation in the nucleus increased dramatically. These results demonstrate that the newly discovered inhibitor hSef is a signaling-dependent regulator of the Ras/ERK MAP kinase cascade that blocks ...

Gene therapy alternative to calcium channel blockers

...otein into the animals' heart muscles. Increased levels of Gem decreased calcium current densities the ch... This suppression, in turn, helps control calcium levels within cells. Calcium, an essential chemical in the process of muscle contraction, is directly invo...

Triple-vaccine strategy stimulates strong HIV-specific immune response in monkeys

...ew vaccine regimen we tested induced unprecedented levels of CD8+ T cells in monkeys." The experimental vacc...alent strains of adenovirus, and similar or higher levels have been reported in other parts of the world. To circumvent this potential difficulty, the researc...

Brain serotonin enzyme finding might explain psychiatric disorders

...that serotonin enzyme have a major effect on brain levels of the chemical messenger, which has been linked t... a nerve impulse in its neighbors. Thus, serotonin levels can profoundly affect brain function, and therefore behavior. "For the first time, we've identified ...

Study suggests first molecular target to halt spread of HPV

... Their effects appeared to be limited to the upper levels of the lesion. "Despite an increase in our understanding of the relationship between HPV and cancer, few advances have been made in the treatment of HPV-associated lesions," Clawson said. "In this study we managed to design and test reagents targeted...

Lack of immune system protein prevents lupus-like condition in mice

...ymphocytes. Earlier research had shown that higher levels of SAP were present in animals with autoimmune con...s, and to test if SAP is present at unusually high levels in human patients with lupus. "Each of the animal models of lupus has slightly different clinical as...

Water study yields a few surprises for New England

... most of Rhode Island (see insert map). Elevated levels of arsenic, mercury, zinc, lead, polycyclic aromat...ion of aquatic life. Although the highest mercury levels in sediments were in urban settings, the fish surveyed from urban waters contained less mercury. Sur...

U of T microbiologists achieve results with pattern recognition software

...sic measurements -- cell size, cell shape and gene levels and by evaluating a cell's potential to grow in a variety of media. They then took these data and did computerized analysis of entire categories of genes in order to predict the functions of individual genes, applying a standard technique for patter...

Researchers discover how worms' noses sense oxygen

...entists know little about how animals sense oxygen levels around them. Researchers from the Berkeley and San...scovered how the nematode C. elegans senses oxygen levels in order to steer clear of surrounding areas that are too low or too high in oxygen. In the process...

University of Chicago scientists pinpoint cellular cause of SIDS

...found that children who die of SIDS have decreased levels of serotonin in areas critical for respiration. Although he didn't know it at the time in 2002, Ramirez and colleague Fernando Pena found the missing link: In the pacemaker neurons critical for gasping, serotonin regulates the sodium channel. Now, R...

Structure solved at Scripps shows how one human protein reduces potency of chemotherapy

... cancers, such as brain tumors, which express high levels of AGT making them resistant to chemotherapy. "Th...me tissues, such as the brain, naturally have high levels of AGT. This enables cancers that arise in the brain to resist chemotherapy. Cancer cells in other p...

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