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Low Oxygen, Key To Fetal Development, Also Offers Cancer Clues

...ygen levels." Understanding why cells respond like they do to hypoxiawould help scientists develop mo...nts stop proliferatingunder low-oxygen conditions, like those found deep inside a largetumor, because radiation and anti-cancer drugs target cells thatare d...

Largest Tyrannosaur Fossil Unearthed In Montana

...s either aTyrannosaurus rex or something very much like it. Certain aspects of theanatomy are different than the 15 or so known skeletons of T. rex, he says, andit appears to exceed all measured skeletons of the dinosaur. "What we do knowis that it's the largest carnivore on the planet.," he says. ...

Researchers Find Association Between Alzheimer's Gene And Mental Impairment After Cardiac Surgery

...concentration and memory problems -- werevery much like the early symptoms of Alzheimer's disease," said Duke'sDr. Mark Newman, chief of cardiothoracic anesthesiology and the study leader."After controlling for other characteristics, we found a statisticallysignificant correlation between patients with th...

Wonder Thread: UD Scientists Report First Protein With Collagen And Elastin-Like Domains

...eCol-P contain a missing glycine. "When a deletion like this is found in other structural collagens," Waite says, "it's certainly lethal to the animal. So, it's quite fascinating to find a missing glycine in a perfectly functional collagen subjected to great stress and strain in marine environments." It's...

OHSU Scientists Discover Mice Lacking Dopamine Receptor Are Supersensitive To Alcohol, Cocaine And Methamphetamine

...te with each other by secreting chemicalmessengers like dopamine that bind to receptors on neighboring ner... receptor plays in an organism*s response to drugs like alcohol,cocaine and methamphetamine, the new research reported by Grandy and hiscolleagues underscor...

Gene For Last Major Form Of Batten Disease Discovered

...ead to treatment for devastating genetic disorders like Battendisease," said Catherine McKeon, Ph.D., of the National Institute of Diabetesand Digestive and Kidney Diseases. Late infantile Batten disease, also called Jansky-Bielchowsky disease or lateinfantile neuronal ceroid lipofuscinosis (LINCL), is on...

Plant-Based Therapies Examined For Colon Cancer Prevention

... in the participants. "Ideally, we would like to find the lowest, optimal dose of each of thethree plant compounds that would safely inhibit the development of colorectalcancer," explains Shiff. The study lasts for up to 10 weeks. During the first two weeks,participants eat a controll...

Report Notes Difficulties In Eliminating E. Coli O157:H7 From Food Supply

...usage and applecider, and experimentally, in foods like mayonnaise and cheddar cheese. Thesurvival time in these foods is greatly extended at refrigeration temperatures(32 F-40 F) as opposed to room temperature. Recent studies have also indicatedthat acid tolerance may increase the pathogen's resistance...

Pharmaceuticals Manufactured In Insect Larvae

...engineered baculoviruses, which are viruses shaped like rods, attack the inside of the larvae, initiate a ...box full of close-spaced pillars -- pillars shaped like small popsicle sticks -- and puts the insects in the box. He also put food in the box. The insects ...

Imaging Studies Illuminate Brain's Response To Cocaine

...he study. Much current understanding of how drugs like cocaine affect the brain has comefrom animal studi...her block individualaspects of cocaine's effects - like the rush versus the craving experience - oras broader treatments for cocaine abuse and addiction." A...

Environmental Engineers Demonstrate Effective Method For Trapping Highway Pollutants

...nly works as a water quality device, but it canact like a water quantity control device to reduce surfaceflooding," said Sansalone. That discovery was completelyunexpected in the Cincinnati area where clay soils are common. Sansalone will continue his research by looking at ways tomake the system more eco...

Notre Dame Paleontologist Finds Damage Done To T. rex Skull

... either a Tyrannosaurus rex or something very much like it. Certain aspects of the anatomy are different than the 15 or so known skeletons of T. rex, according to Rigby, and it appears to exceed all measured skeletons of the dinosaur. "What we do know," he said, "is that this is the largest carnivore on t...

Scientists Find New Trigger For Nerve Cell Death

...ions and water," Yu says. Potassium seemed like the obvious ion to escape because there's so muchof it in the cell. Yu therefore measured potassium movement through themembranes around cultured nerve cells after various events that cause apoptosis. Six hours after the neurons were deprived...

Competitive Inhibition May Enhance Safety Of Minimally Processed Fruits And Vegetables

...c acidbacteria can prevent the growth of pathogens like Listeria monocytogenes,Salmonella typhimurium, and S. aureus. Therefore, products for salad bars andfresh-cut, pre-packaged salads sold at retail may be good applications for thesecultures. Competitive inhibition with LAB also shows great potential ...

Further Proof That An Altered Rb-2/p130 Gene Leads To Lung Cancer

...develop the disease," Giordano said. "We’d like to design alternative therapeutic strategies to...ccessible to everyone," he explained. "We would like to run prospective studies as well to be able to anticipate in some patients when cancer might...

Purdue Study Finds Prehistoric Couch Potato

... American theropods may have been pursuit hunters, like wolves, which would require the ability to run over a long period of time, while the South American dinosaurs perhaps employed a 'dash and dine,' approach, an activity that required only a short burst of activity," he says. Other possible explanation...

Captive Lemurs To Depart For Madagascar Oct. 17 For First Release Into The Wild

...ms. Those programs are underway in distant places like the Duke Primate Center and other MFG institutions, as well as inMadagascar's own two zoos: Tsimbazaza Botanical and Zoological Park and Ivoloina Zoological Park. "This project is an outstanding example of what zoos can do and must do to preserve wi...

Colorado State Anthropologist Finds Fossil Treasures In Africa

...wfossils. "This is really impressive because it's like a big pile of bones glued together." Waddle said the main reason that not much is known about the evolutionary history of this region is the remote location of thecaves; about an 11-hour drive from the nearest town. To get to Bone Cave, the research...

Long-Time NIH Grantee Wins Nobel Prize In Chemistry

...s of the enzyme work together like gears, levers, and ratchets to generate cellular energy. His theories were confirmed in 1994 with a detailed, three-dimensional structure of the enzyme determined by the third recipient of the chemistry prize...

UC Geologist "Flip-Flops" On Understanding Of Crinoid Life Style

...n the other hand, were arranged in aradial pattern like spokes on a bicycle wheel. Meyer thinks he can exp...umented response tostress. They fold up their arms like an umbrella. If Uintacrinusreacted the same way, the organisms would suddenly lose theirbuoyancy and...

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