Half-million dollar landmark achieved for the Methuselah Mouse Prize
...ly extending human life; it is discovering ways to limit and eventually eliminate the destructive effects of human aging, promoting not only longer life but freedom from the effects of aging-related conditions and diseases." Your support of the Methuselah Mouse Prize is the best and most effective way that...Indiana University, EPA to study airborne PCBs
...on, but they usually caution consumers to severely limit their consumption of fish caught in tainted waters. The Great Lakes Basin is inhabited by about 10 percent of the U.S. population and about 25 percent of the Canadian population. The lakes also account for 18 percent of the world's freshwater supply....Prion propagation: Avoiding the toxic oligomer
...r growth while inhibiting oligomer formation might limit the toxic effects of amyloid plaques. The approaches outlined here should lay the foundation for exploring these questions in higher organisms. ...JCI table of contents September 15, 2004
...l myoblast transplantation into injured hearts can limit adverse remodeling. Understanding of donor-host interaction at a cellular level, however, is currently limited. To gain insight into this system, Loren J. Field and colleagues, at the Indiana University School of Medicine, transplanted enhanced GFPex...Sugar-coated sea urchin eggs could have sweet implications for human fertility
...st a small chemical change in a sugar molecule can limit fertilization. The discovery, Biermann said, tells evolutionary biologists that sibling species have found different means to regulate their reproduction. "It helps to understand the process if you think of fertilization as sperm entering through s...Blue marlin in gulf have high mercury levels, A&M study shows
...they be aware of the problem, and they may want to limit their consumption of sport fishes caught," he adds. "We've just scratched the surface on this problem," he believes. "The mercury levels we discovered surprised us and were much higher than we had anticipated. What we need to look at now are the die...New research shows air pollution can reduce children's lung function
...sions and fossil fuels hinder lung development and limit breathing capacity for a lifetime. The study was funded by the National Institute of Environmental Health Sciences (NIEHS), one of the National Institutes of Health, the California Air Resources Board and the Hastings Foundation. The results of the s...New mechanism for display of foreign proteins to immune system
...immune responses," says Dr. Rock. "This could also limit the ability of viruses to evade detection through their counter-surveillance mechanisms that block only one of these pathways."...Flame retardant levels much higher in farmed salmon
... fatty acids found in all salmon, consumers should limit their intake of farmed salmon and wild Chinook. They should also insist that all salmon be clearly labeled to indicate its source, the researchers say. From the data in their earlier study on PCBs and dioxins, the researchers recommended eating two m...Two-pronged attack targeting EGF receptor hinders cancer cell growth
...tosis. And in animal models, the drug combinations limit lung cancer cell growth and tumor development more effectively than any of the drugs used alone. When used singularly in the clinic, the EGFR inhibitors are effective in a relatively small percentage of patients--perhaps 10 to 15 percent. Combination...AGU journal highlights - 29 July 2004
...er volume through ocean straits Imposing a maximum limit on volume discharge for oceanic straits can allowresearchers an improved measure to estimate water movement through thechannels. Melvin E. Stern presents a modified formula for estimating an upperboundary on volume discharge in the Denmark Strait, on...Study by Tufts biologist provides window into progression of some degenerative diseases
...ells die first. So identification of factors that limit expansion, such as these checkpoint proteins, could be very useful in controlling the inheritance and severity of the repeat expansion diseases. "Freudenreich's study is an example of the innovative genetic research being done at Tufts and it will ha...Scientists discover new intricacies in how ulcer bugs stick to stomach
... decreasing the severity of infections, which will limit the damage to the stomach and reduce cases of stomach cancer and ulcers." The lead investigator for the study was Thomas Born, Ph.D., D.D.S., professor of medicinal biochemistry and biophysics at the University of Ume in Ume, Sweden. Born wa...Molecular motor shuttles key protein in response to light
... by mechanically shrinking the pupil to physically limit how much light enters the eye, but also by a chemical response. Building on their previous work showing that specific proteins in eye cells are redistributed in response to bright light, the Johns Hopkins team now reports how a key protein called arr...Sponge substance works well with yew derivative to thwart cancer cell proliferation
...ics of microtubules, paclitaxel and discodermolide limit cancer cells ability to duplicate DNA and divide. The cells are stuck in a pre-division stage of the cell cycle called G2/M. Cancer cells that are restricted to the pre-division stage of the cell cycle cannot divide and ultimately die, thus reducing ...New pulmonary hypertension guideline challenges use of common medication
...rly used to treat high blood pressure because they limit calcium entry into the cells and dilate the constricted systemic blood vessels, thereby lowering blood pressure. This rationale is frequently applied to their use in PAH; however, when they are used in patients with PAH whose narrowed pulmonary arte...Society for conservation biology conference
...from the Wrong Side of the Freeway Major highways limit the migration of large predators and put a major damper on their sex life, according to radio-tracking and genetic study results presented here. Although some individuals do make it across the road to mate, bobcats and coyotes on either side of a la...RICE gets $1.1m from DOD to study neurofibromatosis
... these proteins as targets for new drugs that will limit or eliminate NF-tumor growth in people." Stern's team has received a new four-year, $1.1 million grant from the Department of Defense Neurofibromatosis Research Program to develop the fruit fly model for neurofibromatosis and to test several key prot...Combination of gene therapy and gene silencing prevents neurodegenerative disease
...the right vector for the right cells could help us limit gene expression to those cells where altering expression will have a beneficial effect," Davidson explained. Davidson is optimistic about the potential for using RNA interference gene therapy to treat neurological diseases like HD and spinocerebellar......mass during the growth of livestock species, or to limit muscle loss during times of nutritional deprivation, such as drought." Similarly, muscle wasting experienced by astronauts, bed-ridden patients and the elderly, could be addressed. "A person forced into similar inactivity, would lose in excess of 90 ...