With optical 'tweezers,' researchers pinpoint the rhythmic rigidity of cell skeletons
Endothelial cells, which line the body's blood vessels and regulate the exchange of material between the blood stream and surrounding tissue, are one of the most closely studied types of cell in the body. The cells play an important role in cardiovascular disease. And a greater k...Scientists discover how brain draws and re-draws picture of world
...stance, subjects moved the robot arm in a straight line toward the target from each of the starting positi...ble to reach the target in a more-or-less straight line again, indicating they had learned to account for the forces applied to the robot arm. However, i...Breast cancer susceptibility genes play role in DNA repair
...the cell, Shiekhattar and his colleagues created a line of cells that produce a specially tagged version of BARD1 a protein known to interact with BRCA1. The tag allowed Shiekhattar to isolate BARD1 and any protein found with it. When they found the tag attached to a large complex of proteins, mass spect...With flu season coming, don't forgetexercise?
... can be easily and affordably added to their first line defenses against the illnesses of the season: exercise and oat fiber -glucan. Individually, moderate exercise and the soluble oat fiber -glucan increase immune function and decrease the risk of infection. However, no information exists about the po...Visualizing Alzheimer's disease
...ell damage and degeneration," Holtzman says. "This line of research should provide new insight into the underlying processes involved in the development of Alzheimer's disease and help us determine whether the proteins that accumulate as brain plaques are a useful and feasible target for Alzheimer's thera...High heart risk for lupus patients linked to death of cells lining blood vessels
...LANDO, Fla. Mass suicide by protective cells that line every blood vessel in the body may be to blame for the increased risk of heart and vascular disease faced by patients with the autoimmune disease known as lupus, new research suggests. And the test used to see those dying cells in the bloodstream ma...Enzyme revealed that is key to fungus's ability to breach immune system
...ents of the innate immune system, the body's first line of defense against infection, the study showed. The Duke-based team -- led by HHMI geneticist Joseph Heitman, M.D., director of Duke's Center for Microbial Pathogenesis, and HHMI biochemist Jonathan Stamler, M.D. -- reported their findings in the Nov...NIH student loan repayment awards increase by 66 percent
...lity research.NIH is now accepting applications on line at http://www.lrp.nih.gov . The online application closesDec. 31, 2003. Participants must have a doctoral-leveldegree, devote at least 50% of their time to researchfunded by a nonprofit or government entity. U.S. citizens,permanent residents, or U.S....Ethical guidelines needed before 'nutrigenomic' groceries come to market
...fic links between specific foods and diseases, the line between foods and drugs may become more blurred. This could pose challenges for governments, which have tended to regulate food and drugs differently. Governments are already grappling with what health benefits foods should be permitted to claim, and...Anti-platelet drug blocks bone metastases in mice
..., ML464, would block the spread of a melanoma cell line into bones. They were pleasantly surprised to find that not only did the treatment block bone metastases, it also reduced the development of new tumors in organs like the liver, intestines and kidney. "Bone metastases appear in 75 percent of all pati...Extraterrestrial enigma: missing amino acids in meteorites
...cience: Where and how did life begin? "The bottom line is that you have these materials that come from space," says Steve Macko, professor of environmental sciences at the University of Virginia in Charlottesville. Macko refers specifically to eight of the amino acids found in a certain kind of meteorite...Case researchers discover the mouth's defenses against AIDS
...cavity has put up an innate and formidable defense line of peptides called human beta defensins 2 and 3 (hBD2 and hBD3) that may prevent humans from getting sick and may promote rapid healing from food abrasions or accidental bites to the tongue and mouth. "It is the unique properties of the good bugs f...Multiphoton microscope observes cell membrane action
...mains in biomembrane models coupling curvature and line tension."...Stowers Institute researchers identify stem cell niche
...haped N -cadherin-positive o steoblastic) cells, line the surface of trabecular bone in the marrow cavity, support hematopoietic stem cells, and constitute the primary cellular component of the niche where HSCs reside. By interrupting the signaling pathway through the b one m orphogenetic p rotein (...JCI table of contents, 15 October, 2003
...od vessels (angiogenesis). Endothelial cells (ECs) line blood vessels and attract mural cells, including pericytes, to the vessel wall. Vessels without pericytes demonstrate abnormal branching patterns and leakiness. Because of their critical role in tumor growth, tumor blood vessels are recognized as pot...MicroRNA targets: How big is the iceberg?
In line with the dogma of molecular biology "DNA makes RNA makes protein", RNA molecules have largely been thought of as intermediaries between the information encoded in the genome and the proteins that do the work. More recently, however, it has become cle...From genome comparisons, UCSD researchers learn lessons about evolution and cancer
... genomic architecture. The breast cancer MCF7 cell line is an extreme example of such aberrations, where everything went wrong and all human chromosomes but one got rearranged, fused together, or broken, as if a tall building collapsed after an earthquake. Using the recently developed End Sequence Profil...VIDI awards: Seventy-nine young scientists start their own line of research
... euro. With this the scientist can develop his own line of research for a period of five years. The VIDI g...portunity to develop their own innovative research line and to appoint one or more researchers. Some 278 researchers wrote a research proposal. The proposal......ith the other." The immune system must ride a fine line in its protection of the lung, whose surface area covers an area about the size of a tennis court. It must quickly sound the alarm when it detects a potentially harmful organism or molecule. But it must also tolerate a certain amount of irritation wi...... that travel from the lung to the brain. The first line of defense includes recruited alveolar macrophages...ia two specific mechanisms. The liver is the first line of protection against damage caused by ingested agents and acute liver failure generally results fol...