New compound 'highly efficacious' at reducing human tumour growth
...n-dependent kinase (CDK) control has been directly linked to the molecular pathology of cancer. CDK's are a family of enzymes required for the correct timing and order of events in the cell division cycle. Vascular endothelial growth factor (VEGF) / VEGF-receptor tyrosine kinase (VEGF-RTK) and platelet-deri...Why does cloning create abnormalities? Scientists take a step towards finding out
...umber of possibilities", he said. "They could be linked to fertility medications utilized to induce superovulation, or the progesterone employed to help implantation; in vitro culture conditions which could be related to the length of the culture or the concentrations of certain media components such as s...In the obese, metabolic adaptations post-weight loss lead to regaining of shed pounds
...definitive conclusions in between these studies is linked to the way metabolic mass is estimated, the selection of research subjects, and the methods of weight loss and weight maintenance. Human studies are impractical, because there is no way to identify individuals predisposed to the development of obesi...Underground carbon dioxide storage reduces emissions
... gas and organic matter. CO 2 emissions have been linked to global warming, and there has been a worldwide effort to reduce those emissions and their effects on the planet--the Kyoto Protocol, for example, has mandated these changes. Carbon dioxide sequestration is being evaluated internationally as a via...Melting ice cap gives urgency to new census of marine life project in Arctic Ocean
...e Arctic, how species distribution patterns can be linked to the Arctic's geologic history, the linkages between biodiversity and ecosystem function, and how to correlate species distribution patterns with environmental data to predict the impact of climate change on biodiversity. A 12-member scientific ste...Scientists discover genetic marker responsible for two-fold increase in risk of rheumatoid arthritis
...ubsequent joint damage. The SNP they linked to RA is located in a gene that codes for an enzym...er this year, a study published in Nature Genetics linked this same SNP with type 1 diabetes. Subsequent unpublished research by Dr. Gregersen and his colleag...Study sheds new light on genetic risk for Parkinson's disease
...t the APOE-4 form of the gene, which has long been linked to an increased risk of Alzheimer's disease, is no...requency in people with Alzheimer's disease and is linked with late onset of that disease's symptoms. The APOE type is linked to longevity and is more likely ...Flies may taste bitter better, first map of insect 'tongue' reveals
...ier identified trehalose receptor. The researchers linked individual taste receptor genes with their functio...nd. And consistent with earlier findings, the team linked the trehalose receptor to the flies' normal feeding behavior elicited by that sugar. The researchers...New designed paclitaxel analog kills more cancer cells than natural product
...2-D on paper," said Snyder. "We thought that if we linked the bridge in the right position, maybe it would h...ted with Snyder to design a paclitaxel analog that linked in a new way, and Bane tested it in her assays. "We synthesized a number of the compounds and refine...Antioxidants during pregnancy may help prevent birth defects tied to alcohol
...lved in birth defect formation, particularly those linked to ethanol exposure, such as fetal alcohol spectrum disorders, or FASD. Until now, much of this research at UNC and elsewhere has involved growing cells in the laboratory. "We have used embryonic neural crest cells, which are very sensitive......at is damaged during normal metabolic processes is linked to tumour suppression, says a new University of Toronto study. The researchers discovered that reduction or loss of a protein called Mus81 led to the development of lymphomas and other tumours in mice. The research is published in the June 18 edition...ESA and EADS-CASA sign contract to build instrument for the SMOS mission
... soil and the salt in the oceans are intrinsically linked to the Earth's water cycle and climate. Currently, in-situ measurements for soil moisture are sparse, but if we are to better understand the water cycle so that the forecasting of climate, weather and extreme events such as floods can be improved mor...Ecosystem bounces back from hurricanes
...sirable organisms like the toxic alga Pfiesteria, linked to massive fish kills in the 1990s to areas of the estuary that are less conducive for growth. Pfiesteria populations have shown minimal recovery. The paper also states that commercial catch numbers of shrimp or bivalve molluscs such as clams and sc...Fat cells could provide the key to a longer life
...that genes involved in glucose metabolism might be linked to the genes involved in ageing." Previous studies have shown reducing DAF-2 function during development affects only fertility, but in adulthood reducing function affects only lifespan. The researchers concluded that the two effects influenced diffe...Damaged genes in aging human brain provide clues to cognitive decline
...ciated with stress and repair mechanisms and genes linked to inflammation and immune responses. This is evidence that pathological events may be occurring in the aging brain, possibly related to gene damage. The researchers then went on to show that many of the genes with altered expression in the...LARGE protein can overcome defects in some types of muscular dystrophy
... subset of muscular dystrophies have recently been linked to mutations in a group of enzymes involved in adding sugars to the muscle protein alpha-dystrogylcan, in a process known as glycosylation. Without the attached sugars, alpha-dystroglycan is unable to carry out its function of linking the internal st...New laboratory model can be used to test new treatments for pediatric eye cancer
... according to Dyer. "Because the absence of Rb1 is linked to many other cancers, the St. Jude mouse model holds the potential to teach us more about the genetic basis of other cancers as well." Other authors of the paper are Jiakun Zhang, M.D., Ph.D., and Brett Schweers, Ph.D., both of St. Jude. ......th benefit. 2. Blood circulation alterations are linked to obesity hypertension. Animal studies indicate...ll body obesity. Obstructive sleep apnea has been linked to hypertension in both clinical and epidemiological studies. As such, obstructive sleep apnea may b......the body's energy status and fat stores, have been linked in other studies to increased appetite and obesity. In addition, levels of ghrelin, a hormone thought to trigger appetite that normally declines following a meal, decreased less after meals on the day the women drank the fructose-sweetened beverage...