Tag: "linked" at biology news

Devastating parasitic weed may be felled by toxin borrowed from flies

...ze the impact of their strategy. Hamamouch and Aly linked the parasite-induced promoter to the sarcotoxin gene and introduced the final product into the tobacco genome using Agrobacterium-mediated transformation. The introduced gene was thus silent in the healthy tobacco plant but turned on when it sensed a...

New paclitaxel analog kills more cancer cells than natural product

...he ring and the side chain. "We thought that if we linked the bridge in the right position, maybe it would h...SUNY Binghamton to design a paclitaxel analog that linked in a new way. "We synthesized a number of the compounds and refined the details of how the link is f...

'Top Houston Women in Technology' honoree at UH

...a quicker, more thorough way to assess genetically linked risk factors for such things as diseases and adverse drug reactions." ...

Researchers discover an alternate form for the disease gene associated with Rett syndrome

...ly strikes only girls, the disorder is genetically linked to more widespread neurological disorders such as autism and schizophrenia. Rett symptoms begin to manifest between the first six to eighteen months of life and eventually incapacitates the afflicted children so that they cannot survive without const...

Failure of DNA repair mechanism precedes final stage of deadly leukemia, new Penn study shows

...cle of DNA production and repair. The researchers linked the blocking action to a known oncogene, BCR/ABL, ...ncogene was turned "on" and "off." DNA damage was linked to the protein ATR and measured using comet assays. "If blocking DNA repair proves to be the cause o...

Diet a major factor in breast cancer time for government action

...mones and other growth factors, which are directly linked to breast cancer risk." Eating more of the latter and less of the former food groups would not only reduce obesity, but would reduce the risk of several cancers, as well as cardiovascular and other chronic diseases, he said. Dr. Berrino is currently ...

New study confirms conservation surgery is safe for BRCA breast cancers

...hree times. "The only significant factor we found linked to a higher chance of recurrence was the age of the patient. With every year our patient becomes older the risk of recurrence decreases by 6%. This is a regular decreasing of the risk, but at the same time there are still a lot of uncertainties conce...

UT Southwestern researchers cite recent advances in underlying causes of rare body-fat disorders

... type (FPLD). In 2002 a mutation PPARγ was linked to another type of familial partial lipodystrophy. In 2002 the mutated gene, AGPAT2, linked to congenital generalized lipodystrophy, was identified. In 2002 researchers, in collaboration with...

UT Southwestern researchers discover link that could aid in treatment of kidney cyst diseases

... it was not suspected that these two diseases were linked together," said Dr. Peter Igarashi, chief of nephrology at UT Southwestern and senior author of the study, which appears in today's issue of The Journal of Clinical Investigation. "This finding provides a framework for further investigation. The goal...

Obesity drug inhibits prostate tumor growth

...Smith was able to glean the initial discovery that linked excessive fatty acid synthase activity with flawed metabolism in cancer cells, and identified orlistat as its inhibitor. "This discovery with orlistat has given us a very nice wedge with which we can go in and perturb tumor cells and ask the questio...

Gene links hereditary intestinal disorder with stroke danger

...y Medical Center geneticists. The researchers have linked juvenile polyposis -- characterized by numerous in...e team reported that mutations in one of the genes linked to juvenile polyposis, called MADH4, also spurs the vessel defects characteristic of HHT. In HHT pat...

Johns Hopkins gene hunters pinpoint new cancer gene target

...s Medical Institute have found mutations in a gene linked to the progression of colon and other cancers. The research findings, published online in the March 11 issue of Science , may lead to new therapies and diagnostic tests that target this gene. The gene in which the mutations have been found, called ...

Researchers model embryo implantation and tumour metastasis in fruit flies

... Lipshitz has discovered that a protein previously linked to mammalian embryo implantation, as well as tumour metastasis, plays similar roles in fruit fly development. This research is reported in the featured article in the March 9, 2004 issue of the scientific journal Current Biology. "We were surprised t...

As obesity skyrockets, Joslin Diabetes Center urges action to stem the tide of type 2 diabetes

...ade, the rate of type 2 diabetes, which is closely linked to obesity, has skyrocketed. It is estimated that 18.2 million people in the U.S. have diabetes, and over 90 percent of those have type 2 diabetes. Furthermore, the percentage of adults with diabetes increased 65 percent from 1990 to 2001. "Stati...

Researchers find a protein that controls cell growth

...so-called "tumors suppressor genes" that have been linked to cancer. When these genes aren't fully activated or are mutated, cells lose their ability to limit their own growth. In previous studies, low levels of the p27 protein have been associated with the development of certain tumors of the breast, colon...

UN study shows environmental consequences from ongoing boom in personal computer sales

...leging that exposure to chemicals in their work is linked to birth defects and cancer. These suits are still pending and fears may well be exaggerated, but there is scant scientific evidence to prove nor disprove links to birth defects and cancers. There is a need for epidemiological studies, yet little act...

Watching genes in action

...stry, in which antibodies detect antigens that are linked to genes; and (3) tyramide signal amplification (TSA), which amplifies fluorescent dyes so they can been seen more easily when they are used to illuminate genes. "We used existing technology and we applied it in a novel way" to illuminate simult...

Baker's yeast rises from genome duplication

... as they should, and there are many other diseases linked to gene dosage and misregulation. "These processes are not much different from what happened in yeast," Kellis said. Whole genome duplication may have allowed other organisms besides yeast to achieve evolutionary innovations in one giant leap instead...

Search for macular degeneration genes narrows

...hat a mutation in the gene Hemicentitin-1 might be linked with AMD. After studying over 800 individuals, the Kellogg team saw no evidence of the variant, but suggested that another gene in the same region on chromosome 1 may undergo a change that predisposes individuals to AMD. The next step for Kellogg res...

Faulty DNA replication linked to neurological diseases

... results apply to many other neurological diseases linked to lengthy repeats, including myotonic dystrophy, fragile X mental retardation and Huntington's disease. "Different genes and different parts of those different genes are involved in these diseases. But there is one common feature: when the number of...

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