Tag: "lipids" at biology news

Newly identified master gene key in baby's first breath

...lial cells, which combines surfactant proteins and lipids (essential fat), which in turn produces surfactant. Researchers bred mice with and without the Foxa2 gene. When the gene was deleted, the knockout mice developed all the signs and symptoms of respiratory distress syndrome on the first day of li...

Protein is key to fatal disorder and normal cell function

...crucial protein involved in the transport of vital lipids from the Golgi, where they are made, to where they...e cell surface," Boustany said. One of those vital lipids is galactosylceramide (GalCer). GalCer is a major constituent of lipid rafts. These lipid platforms ...

Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University

...dress both these needs, by linking PLA2-inhibiting lipids to GAG. They report that MFAIDs, given IP, IV or orally, have been effective in treating animal inflammations including endotoxin-induced sepsis, and IBD induced by TNBS, indomethacin or DSS measured by survival, histological, and clinical parameters...

New OHSU lab will speed drug discovery process

...ecules, such as simple peptides, oligonucleotides, lipids and steroids. It also provides open access to a laboratory where users prepare and analyze their own samples by high-pressure liquid chromatography, gas chromatography-mass spectrometry or liquid chromatography-mass spectrometry. The BSR is su...

Whale carcass yields bone-devouring worms

...t evolutionary strategy-they break down whale-bone lipids (fats and oils) directly to provide food for the worms. This is the first time that a lipid-degrading bacteria has been observed in a symbiotic relationship. Co-author Goffredi has been studying this relationship and is currently preparing a separate...

A pathway to blocking autoimmunity

...sponsible for the presentation of self and foreign lipids to T cells. This protein is indispensable for the generation of NKT cells. The researchers state that the work provides insight into how signals from outside the cell can influence differentiation and gene expression and is an entry point for ...

In the obese, metabolic adaptations post-weight loss lead to regaining of shed pounds

...tabolic efficiency and a preference for the use of lipids as opposed to CHO. No change was found from the weight-reduced state in energy expenditure or sleep metabolic rate when the rats were maintained at a constant, reduced body weight for eight subsequent weeks, suggesting that metabolic efficiency was s...

Gestational diabetes not found to alter the metabolic processes in obese pregnant women

...significant differences in percentages of protein, lipids or carbohydrates in their diets across time or bet...ted starvation with increased maternal reliance on lipids rather than carbohydrates for meeting energy needs. Carbohydrates and amino acids are thus made avai...

Genetic modification in mice lowers cholesterol and homocysteine by half

...ough which humans, mice, and other animals provide lipids for high density and low density lipoproteins (HDL... how the body regulates the manufacture of certain lipids and their functions in the human body. The new study reported at ASBMB focuses on the two methods or...

Study detects protein in human milk linked to reduced risk of obesity

...ells and affects how the body processes sugars and lipids -- fatty substances in the blood. It's been suggested that adiponectin is involved in the metabolic syndrome, which includes insulin resistance, obesity, type 2 diabetes and coronary artery disease and occurs in 20-25 percent of adults. Higher level...

Seabed secrets in English clay

...co-exist." Using solvents to extract oily lipids from sediments, the geologists identified the signature organic compounds of green sulfur bacteria using gas chromatographs and mass spectrometers. "Molecules of green sulfur bacteria have a very specific, recognizable pattern or trace that ...

Wet scans

...e the studies of biological materials, such as the lipids that make up fat, which are easily destroyed by the old sample preparation methods. Since the discovery was made, Zik, in cooperation with Yeda, the business arm of the Weizmann Institute, has founded a company, called QuantomiX, based on this tec...

Researchers substitute whole chromosomes to speed the search for genes in common diseases

... by others identifying only two to four genes. In lipids (sitosterol and campesterol, linked with heart disease), they identified 20 locations for genes, compared with a past study by others finding only three genetic locations. With cholesterol, the present study found eight locations for genes compared ...

Creating polymers that act like biomolecules

... and react to stimuli similar to the way proteins, lipids and DNA react in nature. Unlocking how these soluble block polymers are able to self-assemble could potentially lead to a variety of uses such as controlled release systems for sustained and modulated delivery of drugs or gene therapies. ...

Method produces uniform, self-assembled nanocells

...directions. Rather than mixing with the water, the lipids surround it, forming self-assembled nanocells. Controlling flow rates in the microchannels produces nanocells of specific sizes. Faster flows produce smaller cells. Medicine-filled liposomes made in nanosizes should allow for more accurate drug deli...

Biochemistry and Molecular Biology: Research at the Interface of Biochemistry and Human Health

...ersity of Alberta, with symposia on topics such as lipids and obesity, obesity and minority populations, regulation of lipid biosynthesis, and how changes in fat cells influence energy metabolism of the organism. Molecular Recognition and Catalysis organized by Jack E. Dixon, University of California at...

Exposure to low-level magnetic fields causes DNA damage in rat brain cells, researchers find

... atoms that attack cell structures, including DNA, lipids and proteins. To test the idea, the researchers gave some of the rats drugs that either neutralize free radicals or decrease free iron before exposing the animals to the magnetic field. The treatments supported the hypothesis, effectively bl...

New study may explain how fats damage neurons in Alzheimer's patients

...een able to illustrate how alterations in membrane lipids can lead to neuronal dysfunction and death." The n...eimer's disease to study the impact that different lipids in the diet might have on learning and memory. "For the moment, the implications are more for preven...

Linking the immune system with lipid metabolism

...eptors and may have the ability to see some of the lipids that bacteria like Mycobacterium tuberculosis, the... the immune response, though, and endogenous human lipids seem to bind to CD1 as a way of maintaining normal bodily homeostasis. A few years ago, Te...

Common airborne substance makes asthmatics more sensitive to house dust mites: study

...d Clinical Immunology. Endotoxin is a complex of lipids (fats) and sugar molecules that's released through the outer cell wall of common bacteria. When the bacteria die, the cell wall collapses and endotoxin is released into the environment, finding its way into the air and dust. "We know that asthmatic...

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